Gene description for BBS1
Gene name Bardet-Biedl syndrome 1
Gene symbol BBS1
Other names/aliases BBS2L2
Species Homo sapiens
 Database cross references - BBS1
ExoCarta ExoCarta_582
Vesiclepedia VP_582
Entrez Gene 582
HGNC 966
MIM 209901
UniProt Q8NFJ9  
 BBS1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for BBS1
Molecular Function
    patched binding GO:0005113 IBA
    patched binding GO:0005113 IPI
    smoothened binding GO:0005119 IBA
    smoothened binding GO:0005119 IPI
    protein binding GO:0005515 IPI
    phosphoprotein binding GO:0051219 IEA
    RNA polymerase II-specific DNA-binding transcription factor binding GO:0061629 IPI
Biological Process
    microtubule cytoskeleton organization GO:0000226 IEA
    neuron migration GO:0001764 IEA
    visual perception GO:0007601 IEA
    sensory perception of smell GO:0007608 IEA
    photoreceptor cell morphogenesis GO:0008594 IEA
    fertilization GO:0009566 IEA
    dendrite development GO:0016358 IEA
    ventricular system development GO:0021591 IEA
    striatum development GO:0021756 IEA
    hippocampus development GO:0021766 IEA
    cerebral cortex development GO:0021987 IEA
    adult behavior GO:0030534 IEA
    response to endoplasmic reticulum stress GO:0034976 IEA
    olfactory behavior GO:0042048 IEA
    hormone metabolic process GO:0042445 IEA
    Golgi to plasma membrane protein transport GO:0043001 IMP
    fat cell differentiation GO:0045444 IEA
    photoreceptor cell maintenance GO:0045494 IMP
    brain morphogenesis GO:0048854 IEA
    cartilage development GO:0051216 IEA
    retina development in camera-type eye GO:0060041 IEA
    cilium assembly GO:0060271 IMP
    cilium assembly GO:0060271 NAS
    regulation of cilium beat frequency involved in ciliary motility GO:0060296 IEA
    neural precursor cell proliferation GO:0061351 IEA
    protein localization to cilium GO:0061512 IBA
    protein localization to cilium GO:0061512 IMP
    non-motile cilium assembly GO:1905515 IBA
    non-motile cilium assembly GO:1905515 IMP
Subcellular Localization
    centrosome GO:0005813 IBA
    centrosome GO:0005813 IDA
    cytosol GO:0005829 TAS
    axoneme GO:0005930 IBA
    motile cilium GO:0031514 IEA
    centriolar satellite GO:0034451 IEA
    BBSome GO:0034464 IBA
    BBSome GO:0034464 IDA
    BBSome GO:0034464 IPI
    ciliary membrane GO:0060170 IDA
 Experiment description of studies that identified BBS1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for BBS1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PRIM2 5558
Affinity Capture-MS Homo sapiens
2 OSBPL10  
Affinity Capture-MS Homo sapiens
3 NME3 4832
Affinity Capture-MS Homo sapiens
4 BBS7 55212
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 ARFGAP2 84364
Affinity Capture-MS Homo sapiens
6 PBK  
Affinity Capture-MS Homo sapiens
7 UBE3A 7337
Affinity Capture-MS Homo sapiens
8 ROCK2 9475
Affinity Capture-MS Homo sapiens
9 TERF2IP 54386
Affinity Capture-MS Homo sapiens
10 VWA5A 4013
Affinity Capture-MS Homo sapiens
11 PARK7 11315
Affinity Capture-MS Homo sapiens
12 SBDS 51119
Affinity Capture-MS Homo sapiens
13 CAB39 51719
Affinity Capture-MS Homo sapiens
14 KIAA1598 57698
Affinity Capture-MS Homo sapiens
15 APEX1 328
Affinity Capture-RNA Homo sapiens
16 CCDC43 124808
Affinity Capture-MS Homo sapiens
17 PDCD10 11235
Affinity Capture-MS Homo sapiens
18 PPP1R12A 4659
Affinity Capture-MS Homo sapiens
19 EMILIN1 11117
Affinity Capture-MS Homo sapiens
20 IARS2 55699
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 C18orf25 147339
Affinity Capture-MS Homo sapiens
22 LIG1 3978
Affinity Capture-MS Homo sapiens
23 PCBD1 5092
Affinity Capture-MS Homo sapiens
24 PRC1 9055
Affinity Capture-MS Homo sapiens
25 MCTS1 28985
Affinity Capture-MS Homo sapiens
26 PSME1 5720
Affinity Capture-MS Homo sapiens
27 RNF126  
Affinity Capture-MS Homo sapiens
28 FBXW5  
Affinity Capture-MS Homo sapiens
29 HSPA8 3312
Affinity Capture-MS Homo sapiens
30 LZTFL1 54585
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 XRCC4  
Affinity Capture-MS Homo sapiens
32 WBP4  
Affinity Capture-MS Homo sapiens
33 CHMP1A 5119
Affinity Capture-MS Homo sapiens
34 ENSA 2029
Affinity Capture-MS Homo sapiens
35 RTFDC1  
Affinity Capture-MS Homo sapiens
36 GLIS2  
Affinity Capture-Western Homo sapiens
37 WDR53  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 BTF3L4 91408
Affinity Capture-MS Homo sapiens
39 DTYMK 1841
Affinity Capture-MS Homo sapiens
40 PRPS2 5634
Affinity Capture-MS Homo sapiens
41 VRK1 7443
Affinity Capture-MS Homo sapiens
42 TRIP10 9322
Affinity Capture-MS Homo sapiens
43 CIB1 10519
Affinity Capture-MS Homo sapiens
44 BBS4 585
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 RGS10 6001
Affinity Capture-MS Homo sapiens
46 FAM49B 51571
Affinity Capture-MS Homo sapiens
47 BBS2 583
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 PICALM 8301
Affinity Capture-MS Homo sapiens
49 ENAH 55740
Affinity Capture-MS Homo sapiens
50 MESDC2 23184
Affinity Capture-MS Homo sapiens
51 PPP1R12B 4660
Affinity Capture-MS Homo sapiens
52 CWF19L1 55280
Affinity Capture-MS Homo sapiens
53 TOMM34 10953
Affinity Capture-MS Homo sapiens
54 PPM1M  
Affinity Capture-MS Homo sapiens
55 TSSC1 7260
Affinity Capture-MS Homo sapiens
56 BBS5 129880
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 SLK 9748
Affinity Capture-MS Homo sapiens
58 PUS7 54517
Affinity Capture-MS Homo sapiens
59 OMD 4958
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 GATC  
Affinity Capture-MS Homo sapiens
61 FKBP5 2289
Affinity Capture-MS Homo sapiens
62 TRIM44  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 CMSS1  
Affinity Capture-MS Homo sapiens
64 UBLCP1  
Affinity Capture-MS Homo sapiens
65 SOHLH1  
Affinity Capture-MS Homo sapiens
66 BBS9 27241
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 SBNO1 55206
Affinity Capture-MS Homo sapiens
68 SF3B3 23450
Affinity Capture-MS Homo sapiens
69 NAA25 80018
Affinity Capture-MS Homo sapiens
70 FTL 2512
Affinity Capture-MS Homo sapiens
71 DPP3 10072
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 PRKCSH 5589
Affinity Capture-MS Homo sapiens
73 STK24 8428
Affinity Capture-MS Homo sapiens
74 TSFM 10102
Affinity Capture-MS Homo sapiens
75 ROCK1 6093
Affinity Capture-MS Homo sapiens
76 AVIL  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
77 CLUAP1 23059
Affinity Capture-MS Homo sapiens
78 KEAP1 9817
Affinity Capture-MS Homo sapiens
79 SRP19 6728
Affinity Capture-MS Homo sapiens
80 ARHGAP18 93663
Affinity Capture-MS Homo sapiens
81 STK26 51765
Affinity Capture-MS Homo sapiens
82 PDCD2 5134
Affinity Capture-MS Homo sapiens
83 RAB8A 4218
Affinity Capture-MS Homo sapiens
84 PPP4R1L  
Affinity Capture-MS Homo sapiens
85 EIF3J 8669
Affinity Capture-MS Homo sapiens
86 IFT43  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
87 TTC8 123016
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
88 PTGES3 10728
Affinity Capture-MS Homo sapiens
89 KIF1BP 26128
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 HAVCR2  
Affinity Capture-MS Homo sapiens
91 SNX29  
Affinity Capture-MS Homo sapiens
92 PDRG1  
Affinity Capture-MS Homo sapiens
93 DARS2 55157
Affinity Capture-MS Homo sapiens
94 PARN  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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