Gene description for TTC8
Gene name tetratricopeptide repeat domain 8
Gene symbol TTC8
Other names/aliases BBS8
RP51
Species Homo sapiens
 Database cross references - TTC8
ExoCarta ExoCarta_123016
Vesiclepedia VP_123016
Entrez Gene 123016
HGNC 20087
MIM 608132
UniProt Q8TAM2  
 TTC8 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for TTC8
Molecular Function
    protein binding GO:0005515 IPI
    RNA polymerase II-specific DNA-binding transcription factor binding GO:0061629 IPI
Biological Process
    establishment of planar polarity GO:0001736 IEA
    axon guidance GO:0007411 IEA
    sensory perception of smell GO:0007608 IEA
    protein transport GO:0015031 IEA
    olfactory bulb development GO:0021772 IEA
    regulation of protein localization GO:0032880 IEA
    multicellular organism growth GO:0035264 IEA
    establishment of epithelial cell apical/basal polarity GO:0045198 IEA
    fat cell differentiation GO:0045444 IEA
    establishment of anatomical structure orientation GO:0048560 IMP
    sensory processing GO:0050893 TAS
    regulation of stress fiber assembly GO:0051492 IEA
    inner ear receptor cell stereocilium organization GO:0060122 IEA
    camera-type eye photoreceptor cell differentiation GO:0060219 IEA
    cilium assembly GO:0060271 NAS
    cilium assembly GO:0060271 TAS
    renal tubule development GO:0061326 IEA
    protein localization to plasma membrane GO:0072659 IEA
    multi-ciliated epithelial cell differentiation GO:1903251 IEA
    non-motile cilium assembly GO:1905515 IBA
Subcellular Localization
    mitochondrion GO:0005739 HTP
    centrosome GO:0005813 IDA
    cytosol GO:0005829 TAS
    cilium GO:0005929 IDA
    photoreceptor connecting cilium GO:0032391 IEA
    centriolar satellite GO:0034451 IEA
    BBSome GO:0034464 IBA
    BBSome GO:0034464 IDA
    BBSome GO:0034464 IPI
    ciliary basal body GO:0036064 IBA
    ciliary basal body GO:0036064 IDA
    ciliary membrane GO:0060170 IDA
    non-motile cilium GO:0097730 IBA
 Experiment description of studies that identified TTC8 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TTC8
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 BBS7 55212
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 NME3 4832
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 PTH2R  
Affinity Capture-MS Homo sapiens
4 BBS4 585
Affinity Capture-MS Homo sapiens
5 BBS5 129880
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 BBS2 583
Affinity Capture-MS Homo sapiens
7 NPAS1  
Affinity Capture-MS Homo sapiens
8 CDC16 8881
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 BBIP1  
Affinity Capture-MS Homo sapiens
10 BBS1 582
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 BBS9 27241
Affinity Capture-MS Homo sapiens
12 GPR45  
Affinity Capture-MS Homo sapiens
13 SOHLH1  
Affinity Capture-MS Homo sapiens
14 HCST  
Affinity Capture-MS Homo sapiens
15 LZTFL1 54585
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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