Gene description for BBS7
Gene name Bardet-Biedl syndrome 7
Gene symbol BBS7
Other names/aliases BBS2L1
Species Homo sapiens
 Database cross references - BBS7
ExoCarta ExoCarta_55212
Vesiclepedia VP_55212
Entrez Gene 55212
HGNC 18758
MIM 607590
UniProt Q8IWZ6  
 BBS7 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for BBS7
Molecular Function
    protein binding GO:0005515 IPI
    RNA polymerase II-specific DNA-binding transcription factor binding GO:0061629 IPI
Biological Process
    eye development GO:0001654 IEA
    heart looping GO:0001947 ISS
    regulation of transcription by RNA polymerase II GO:0006357 IPI
    smoothened signaling pathway GO:0007224 IEA
    determination of left/right symmetry GO:0007368 ISS
    brain development GO:0007420 IEA
    visual perception GO:0007601 IEA
    protein localization GO:0008104 IBA
    protein transport GO:0015031 IEA
    melanosome transport GO:0032402 ISS
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 IPI
    fat cell differentiation GO:0045444 ISS
    intracellular transport GO:0046907 IBA
    digestive tract morphogenesis GO:0048546 ISS
    pigment granule aggregation in cell center GO:0051877 ISS
    limb development GO:0060173 IEA
    cilium assembly GO:0060271 IBA
    cilium assembly GO:0060271 ISS
    cilium assembly GO:0060271 NAS
    primary palate development GO:1903929 IEA
    non-motile cilium assembly GO:1905515 IEA
Subcellular Localization
    photoreceptor outer segment GO:0001750 IEA
    nucleus GO:0005634 IEA
    centrosome GO:0005813 IDA
    cytosol GO:0005829 TAS
    axoneme GO:0005930 IBA
    membrane GO:0016020 IBA
    centriolar satellite GO:0034451 IEA
    BBSome GO:0034464 IBA
    BBSome GO:0034464 IDA
    BBSome GO:0034464 IPI
    ciliary basal body GO:0036064 IBA
    neuron projection GO:0043005 IBA
    ciliary membrane GO:0060170 IDA
 Experiment description of studies that identified BBS7 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for BBS7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DNAJC7 7266
Proximity Label-MS Homo sapiens
2 C5orf34  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 SHKBP1  
Affinity Capture-MS Homo sapiens
4 FBXL4 26235
Affinity Capture-MS Homo sapiens
5 FAM208A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 TARSL2 123283
Affinity Capture-MS Homo sapiens
7 MAP2K2 5605
Affinity Capture-MS Homo sapiens
8 CEP164  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 DNAJC11 55735
Proximity Label-MS Homo sapiens
10 PER1  
Affinity Capture-MS Homo sapiens
11 LAMTOR1 55004
Proximity Label-MS Homo sapiens
12 PMS1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 TP53 7157
Affinity Capture-MS Homo sapiens
14 KLK5 25818
Affinity Capture-MS Homo sapiens
15 ALMS1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 CLUAP1 23059
Affinity Capture-MS Homo sapiens
17 SMG8 55181
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 LZTFL1 54585
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 DNAJA2 10294
Proximity Label-MS Homo sapiens
20 HIST1H1D 3007
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 CAMSAP3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 MYO1D 4642
Affinity Capture-MS Homo sapiens
23 DNAJB2 3300
Proximity Label-MS Homo sapiens
24 DHX35  
Affinity Capture-MS Homo sapiens
25 LRRC27  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 BBS5 129880
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 MADD 8567
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 NR3C1 2908
Proximity Label-MS Homo sapiens
29 RIPK4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 USP54 159195
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 TTC21A  
Affinity Capture-MS Homo sapiens
32 SH3PXD2B 285590
Affinity Capture-MS Homo sapiens
33 MTO1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 DSCC1  
Affinity Capture-MS Homo sapiens
35 DNAJB3 414061
Proximity Label-MS Homo sapiens
36 CNKSR3 154043
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 PWP2 5822
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 SIMC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 FAM83D 81610
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 WDR36 134430
Affinity Capture-MS Homo sapiens
41 ERF  
Affinity Capture-MS Homo sapiens
42 JUN 3725
Reconstituted Complex Homo sapiens
43 DDX39A 10212
Affinity Capture-MS Homo sapiens
44 PI4K2B 55300
Affinity Capture-MS Homo sapiens
45 NRBP1 29959
Affinity Capture-MS Homo sapiens
46 TRIM37  
Affinity Capture-MS Homo sapiens
47 MIOS 54468
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 RPS24 6229
Proximity Label-MS Homo sapiens
49 BBS1 582
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 BBS9 27241
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 SCGN  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 WHAMMP3  
Affinity Capture-MS Homo sapiens
53 WIPI2 26100
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 KANK2 25959
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 TTC8 123016
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 THBS3 7059
Affinity Capture-MS Homo sapiens
57 ZNF655  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 PEAK1 79834
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 NME3 4832
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 PLEKHO2 80301
Affinity Capture-MS Homo sapiens
61 RFWD3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 STIL  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 BBS4 585
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 MARCH7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 ZNF518A 9849
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 CCDC88A 55704
Affinity Capture-MS Homo sapiens
67 ZNHIT2 741
Affinity Capture-MS Homo sapiens
68 BBS12  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 BBS2 583
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 INTS6 26512
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 BBS10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 CCDC8  
Affinity Capture-MS Homo sapiens
73 GNL3L 54552
Affinity Capture-MS Homo sapiens
74 MTMR6 9107
Affinity Capture-MS Homo sapiens
75 KLHL14 57565
Affinity Capture-MS Homo sapiens
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