Gene description for PEAK1
Gene name pseudopodium-enriched atypical kinase 1
Gene symbol PEAK1
Other names/aliases SGK269
Species Homo sapiens
 Database cross references - PEAK1
ExoCarta ExoCarta_79834
Entrez Gene 79834
HGNC 29431
MIM 614248
UniProt Q9H792  
 PEAK1 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for PEAK1
Molecular Function
    protein kinase activity GO:0004672 IBA
    non-membrane spanning protein tyrosine kinase activity GO:0004715 IDA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
Biological Process
    peptidyl-tyrosine phosphorylation GO:0018108 IEA
    cell migration GO:0016477 IDA
    substrate adhesion-dependent cell spreading GO:0034446 IDA
    protein autophosphorylation GO:0046777 IDA
    protein phosphorylation GO:0006468 IBA
Subcellular Localization
    actin cytoskeleton GO:0015629 IDA
    plasma membrane GO:0005886 IDA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IDA
    focal adhesion GO:0005925 IDA
 Experiment description of studies that identified PEAK1 in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for PEAK1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which PEAK1 is involved
No pathways found





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