Gene description for TOR1AIP1
Gene name torsin A interacting protein 1
Gene symbol TOR1AIP1
Other names/aliases LAP1
Species Homo sapiens
 Database cross references - TOR1AIP1
ExoCarta ExoCarta_26092
Entrez Gene 26092
HGNC 29456
MIM 614512
UniProt Q5JTV8  
 TOR1AIP1 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for TOR1AIP1
Molecular Function
    ATPase binding GO:0051117 IPI
    lamin binding GO:0005521 IEA
    cytoskeletal protein binding GO:0008092 IPI
    ATPase activator activity GO:0001671 IDA
Biological Process
    protein localization to nucleus GO:0034504 IEA
    nuclear membrane organization GO:0071763 IEA
    positive regulation of ATPase activity GO:0032781 IDA
Subcellular Localization
    nucleus GO:0005634 IDA
    nuclear inner membrane GO:0005637 IEA
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified TOR1AIP1 in exosomes
Experiment ID 235
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for TOR1AIP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LMNA 4000
Invitro Homo sapiens
2 PPP1CA 5499
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TOR1AIP1 is involved
No pathways found

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