Gene description for HPDL
Gene name 4-hydroxyphenylpyruvate dioxygenase-like
Gene symbol HPDL
Other names/aliases 4-HPPD-L
GLOXD1
Species Homo sapiens
 Database cross references - HPDL
ExoCarta ExoCarta_84842
Entrez Gene 84842
HGNC 28242
UniProt Q96IR7  
 HPDL identified in exosomes derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
 Gene ontology annotations for HPDL
Molecular Function
    4-hydroxyphenylpyruvate dioxygenase activity GO:0003868 IEA
    metal ion binding GO:0046872 IEA
Biological Process
    oxidation-reduction process GO:0055114 IEA
    aromatic amino acid family metabolic process GO:0009072 IEA
 Experiment description of studies that identified HPDL in exosomes
1
Experiment ID 191
ISEV standards
EV Biophysical techniques
Alix
EV Cytosolic markers
CD81|CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for HPDL
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which HPDL is involved
No pathways found





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