Gene description for RGS10
Gene name regulator of G-protein signaling 10
Gene symbol RGS10
Other names/aliases -
Species Homo sapiens
 Database cross references - RGS10
ExoCarta ExoCarta_6001
Vesiclepedia VP_6001
Entrez Gene 6001
HGNC 9992
MIM 602856
UniProt O43665  
 RGS10 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for RGS10
Molecular Function
    GTPase activator activity GO:0005096 IBA
Biological Process
    positive regulation of GTPase activity GO:0043547 IBA
    termination of G-protein coupled receptor signaling pathway GO:0038032 IEA
Subcellular Localization
    cytoplasm GO:0005737 IBA
    nucleus GO:0005634 IDA
    plasma membrane GO:0005886 IBA
    dendritic spine GO:0043197 IEA
    axon terminus GO:0043679 IEA
    neuronal cell body GO:0043025 IEA
 Experiment description of studies that identified RGS10 in exosomes
1
Experiment ID 217
MISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|CD81|CD9|CD63
EV Enriched markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for RGS10
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GNAZ 2781
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
2 GNRHR  
Invivo Homo sapiens
3 SAP18 10284
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 GNAI3 2773
Invivo Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
5 ACP6 51205
Affinity Capture-MS Homo sapiens
6 EIF6 3692
Affinity Capture-MS Homo sapiens
7 GNAI1 2770
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which RGS10 is involved
PathwayEvidenceSource
G alpha (i) signalling events TAS Reactome





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