Gene description for ROCK1
Gene name	Rho-associated, coiled-coil containing protein kinase 1
Gene symbol	ROCK1
Other names/aliases	P160ROCK ROCK-I
Species	Homo sapiens
Database cross references - ROCK1
ExoCarta	ExoCarta_6093
Entrez Gene	6093
HGNC	10251
MIM	601702
UniProt	Q13464
ROCK1 identified in exosomes derived from the following tissue/cell type
Endothelial cells	26027894
Platelets	25332113
Platelets	25332113
Platelets	25332113
Thymus	23844026

Gene ontology annotations for ROCK1

Molecular Function     protein binding GO:0005515 IPI     ATP binding GO:0005524 IEA     metal ion binding GO:0046872 IEA     protein serine/threonine kinase activity GO:0004674 IDA     GTP-Rho binding GO:0017049 IEA     protein kinase activity GO:0004672 TAS Biological Process     negative regulation of angiogenesis GO:0016525 IMP     ephrin receptor signaling pathway GO:0048013 TAS     negative regulation of protein binding GO:0032091 IDA     regulation of cell motility GO:2000145 TAS     protein phosphorylation GO:0006468 IEA     Rho protein signal transduction GO:0007266 IEA     signal transduction GO:0007165 TAS     apical constriction GO:0003383 IEA     leukocyte tethering or rolling GO:0050901 IDA     programmed cell death GO:0012501 TAS     regulation of cell adhesion GO:0030155 TAS     regulation of focal adhesion assembly GO:0051893 TAS     leukocyte cell-cell adhesion GO:0007159 IDA     cellular component disassembly involved in execution phase of apoptosis GO:0006921 TAS     axon guidance GO:0007411 TAS     bleb assembly GO:0032060 IEA     actin cytoskeleton organization GO:0030036 IEA     regulation of keratinocyte differentiation GO:0045616 IMP     small GTPase mediated signal transduction GO:0007264 TAS     regulation of establishment of cell polarity GO:2000114 TAS     myoblast migration GO:0051451 ISS     smooth muscle contraction GO:0006939 TAS     apoptotic process GO:0006915 TAS     regulation of actin cytoskeleton organization GO:0032956 TAS     vascular endothelial growth factor receptor signaling pathway GO:0048010 TAS     regulation of stress fiber assembly GO:0051492 TAS     positive regulation of focal adhesion assembly GO:0051894 ISS     membrane to membrane docking GO:0022614 IDA     negative regulation of neuron apoptotic process GO:0043524 IEA     leukocyte migration GO:0050900 IDA Subcellular Localization     lamellipodium GO:0030027 ISS     cytosol GO:0005829 TAS     bleb GO:0032059 IEA     plasma membrane GO:0005886 ISS     ruffle GO:0001726 ISS     centriole GO:0005814 IEA     Golgi membrane GO:0000139 IEA     cytoskeleton GO:0005856 ISS