Gene description for TAF4
Gene name TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa
Gene symbol TAF4
Other names/aliases TAF2C
Species Homo sapiens
 Database cross references - TAF4
ExoCarta ExoCarta_6874
Entrez Gene 6874
HGNC 11537
MIM 601796
UniProt O00268  
 TAF4 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for TAF4
Molecular Function
    DNA binding GO:0003677 IDA
    protein binding GO:0005515 IPI
    transcription coactivator activity GO:0003713 TAS
    protein heterodimerization activity GO:0046982 IEA
    sequence-specific DNA binding transcription factor activity GO:0003700 IDA
Biological Process
    transcription initiation from RNA polymerase II promoter GO:0006367 TAS
    ovarian follicle development GO:0001541 IEA
    DNA-templated transcription, initiation GO:0006352 IDA
    gene expression GO:0010467 TAS
    viral process GO:0016032 TAS
    transcription elongation from RNA polymerase II promoter GO:0006368 TAS
    transcription from RNA polymerase II promoter GO:0006366 TAS
    positive regulation of transcription, DNA-templated GO:0045893 IDA
Subcellular Localization
    MLL1 complex GO:0071339 IDA
    nucleoplasm GO:0005654 TAS
    transcription factor TFTC complex GO:0033276 IDA
    cytoplasm GO:0005737 IDA
    transcription factor TFIID complex GO:0005669 IDA
 Experiment description of studies that identified TAF4 in exosomes
Experiment ID 237
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for TAF4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TAF5  
Affinity Capture-Western Homo sapiens
2 SUPT3H  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
3 SP1  
Two-hybrid Homo sapiens
4 TBP  
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
5 GCN5L2  
Affinity Capture-Western Homo sapiens
6 TBN  
Far Western Homo sapiens
7 GTF2A2  
Reconstituted Complex Homo sapiens
8 CREM  
Reconstituted Complex Homo sapiens
9 TAF10 6881
Affinity Capture-Western Homo sapiens
10 TAF12  
Far Western Homo sapiens
11 TAF4 6874
Far Western Homo sapiens
Far Western Homo sapiens
12 SAP130  
Affinity Capture-Western Homo sapiens
13 CBX5 23468
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
14 TAF1  
Reconstituted Complex Homo sapiens
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