Gene description for CETN2
Gene name centrin, EF-hand protein, 2
Gene symbol CETN2
Other names/aliases CALT
CEN2
Species Homo sapiens
 Database cross references - CETN2
ExoCarta ExoCarta_1069
Vesiclepedia VP_1069
Entrez Gene 1069
HGNC 1867
MIM 300006
UniProt P41208  
 CETN2 identified in exosomes derived from the following tissue/cell type
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
 Gene ontology annotations for CETN2
Molecular Function
    heterotrimeric G-protein binding GO:0032795 IEA
    protein binding GO:0005515 IPI
    microtubule binding GO:0008017 IEA
    calcium ion binding GO:0005509 NAS
    G-protein beta/gamma-subunit complex binding GO:0031683 IEA
Biological Process
    cell division GO:0051301 IEA
    mitotic cell cycle GO:0000278 TAS
    mitotic nuclear division GO:0007067 NAS
    cellular protein metabolic process GO:0044267 TAS
    centriole replication GO:0007099 IMP
    organelle organization GO:0006996 TAS
    protein sumoylation GO:0016925 TAS
    spermatogenesis GO:0007283 IEA
    regulation of cytokinesis GO:0032465 IMP
    nucleotide-excision repair GO:0006289 IDA
    G2/M transition of mitotic cell cycle GO:0000086 TAS
    post-translational protein modification GO:0043687 TAS
Subcellular Localization
    photoreceptor connecting cilium GO:0032391 IEA
    cytosol GO:0005829 TAS
    nucleoplasm GO:0005654 TAS
    intracellular GO:0005622 IDA
    ciliary basal body GO:0036064 IEA
    XPC complex GO:0071942 IDA
    centriole GO:0005814 IDA
    centrosome GO:0005813 NAS
 Experiment description of studies that identified CETN2 in exosomes
1
Experiment ID 363
MISEV standards
✘ EV Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
EV Enriched markers
✔
DCLK1
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M.
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 364
MISEV standards
✘ EV Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
EV Enriched markers
✔
DCLK1
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M.
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
3
Experiment ID 365
MISEV standards
✘ EV Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
EV Enriched markers
✔
DCLK1
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M.
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for CETN2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RAD23B 5887
Affinity Capture-MS Homo sapiens
2 SFI1 9814
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
3 XPC  
Co-purification Homo sapiens
Reconstituted Complex Homo sapiens
View the network image/svg+xml



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