Gene description for ERCC2
Gene name	excision repair cross-complementation group 2
Gene symbol	ERCC2
Other names/aliases	COFS2 EM9 TFIIH TTD XPD
Species	Homo sapiens
Database cross references - ERCC2
ExoCarta	ExoCarta_2068
Entrez Gene	2068
HGNC	3434
MIM	126340
UniProt	P18074
ERCC2 identified in exosomes derived from the following tissue/cell type
Thymus	23844026

Gene ontology annotations for ERCC2

Molecular Function     protein C-terminus binding GO:0008022 IPI     DNA-dependent ATPase activity GO:0008094 TAS     DNA binding GO:0003677 IEA     protein N-terminus binding GO:0047485 IPI     4 iron, 4 sulfur cluster binding GO:0051539 IEA     protein kinase activity GO:0004672 IDA     protein binding GO:0005515 IPI     ATP-dependent DNA helicase activity GO:0004003 IEA     RNA polymerase II carboxy-terminal domain kinase activity GO:0008353 IDA     metal ion binding GO:0046872 IEA     5'-3' DNA helicase activity GO:0043139 IDA     ATP binding GO:0005524 IEA Biological Process     extracellular matrix organization GO:0030198 IEA     response to hypoxia GO:0001666 IEA     transcription from RNA polymerase I promoter GO:0006360 TAS     spinal cord development GO:0021510 IEA     gene expression GO:0010467 TAS     positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA     apoptotic process GO:0006915 IMP     transcription elongation from RNA polymerase II promoter GO:0006368 TAS     hair follicle maturation GO:0048820 IEA     UV protection GO:0009650 IGI     nucleotide-excision repair GO:0006289 TAS     bone mineralization GO:0030282 IEA     aging GO:0007568 IEA     in utero embryonic development GO:0001701 IEA     DNA duplex unwinding GO:0032508 IEA     viral process GO:0016032 TAS     multicellular organism growth GO:0035264 IEA     cell proliferation GO:0008283 IEA     embryonic cleavage GO:0040016 IEA     chromosome segregation GO:0007059 IMP     erythrocyte maturation GO:0043249 IEA     hematopoietic stem cell differentiation GO:0060218 IEA     7-methylguanosine mRNA capping GO:0006370 TAS     transcription initiation from RNA polymerase II promoter GO:0006367 TAS     nucleotide-excision repair, DNA damage removal GO:0000718 TAS     post-embryonic development GO:0009791 IEA     transcription elongation from RNA polymerase I promoter GO:0006362 TAS     hair cell differentiation GO:0035315 IMP     regulation of mitotic cell cycle phase transition GO:1901990 IMP     DNA repair GO:0006281 TAS     response to oxidative stress GO:0006979 IMP     positive regulation of transcription, DNA-templated GO:0045893 IDA     regulation of gene expression, epigenetic GO:0040029 TAS     transcription from RNA polymerase II promoter GO:0006366 TAS     termination of RNA polymerase I transcription GO:0006363 TAS     central nervous system myelin formation GO:0032289 IEA     transcription initiation from RNA polymerase I promoter GO:0006361 TAS     transcription-coupled nucleotide-excision repair GO:0006283 TAS     small molecule metabolic process GO:0044281 TAS     positive regulation of DNA binding GO:0043388 IEA     protein phosphorylation GO:0006468 IDA     positive regulation of viral transcription GO:0050434 TAS     nucleotide-excision repair, DNA incision GO:0033683 IMP     negative regulation of gene expression, epigenetic GO:0045814 TAS Subcellular Localization     nucleoplasm GO:0005654 TAS     spindle GO:0005819 IDA     holo TFIIH complex GO:0005675 TAS     core TFIIH complex GO:0000439 IEA     cyclin-dependent protein kinase activating kinase holoenzyme complex GO:0019907 IDA     nucleus GO:0005634 IDA     MMXD complex GO:0071817 IDA     cytoplasm GO:0005737 IDA