Gene description for HERC5
Gene name HECT and RLD domain containing E3 ubiquitin protein ligase 5
Gene symbol HERC5
Other names/aliases CEB1
Species Homo sapiens
 Database cross references - HERC5
ExoCarta ExoCarta_51191
Entrez Gene 51191
HGNC 24368
MIM 608242
UniProt Q9UII4  
 HERC5 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for HERC5
Molecular Function
    ligase activity GO:0016874 IEA
    protein binding GO:0005515 IPI
    ISG15 transferase activity GO:0042296 IDA
    poly(A) RNA binding GO:0044822 IDA
    ubiquitin-protein transferase activity GO:0004842 IBA
Biological Process
    defense response to virus GO:0051607 IEA
    protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:0042787 IBA
    negative regulation of type I interferon production GO:0032480 TAS
    regulation of cyclin-dependent protein serine/threonine kinase activity GO:0000079 TAS
    ISG15-protein conjugation GO:0032020 IDA
    regulation of defense response to virus GO:0050688 IDA
    cytokine-mediated signaling pathway GO:0019221 TAS
    innate immune response GO:0045087 TAS
Subcellular Localization
    cytosol GO:0005829 TAS
    cytoplasm GO:0005737 IBA
    perinuclear region of cytoplasm GO:0048471 IEA
 Experiment description of studies that identified HERC5 in exosomes
Experiment ID 126
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for HERC5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CCNE1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
2 CCNA2 890
Reconstituted Complex Homo sapiens
3 CCND1 595
Reconstituted Complex Homo sapiens
4 CCNB1 891
Reconstituted Complex Homo sapiens
5 CDKN1A  
Reconstituted Complex Homo sapiens
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