Gene description for SFI1
Gene name Sfi1 homolog, spindle assembly associated (yeast)
Gene symbol SFI1
Other names/aliases PISD
PPP1R139
hSfi1p
Species Homo sapiens
 Database cross references - SFI1
ExoCarta ExoCarta_9814
Vesiclepedia VP_9814
Entrez Gene 9814
HGNC 29064
MIM 612765
UniProt A8K8P3  
 SFI1 identified in exosomes derived from the following tissue/cell type
Malignant pleural effusions 14975938    
 Gene ontology annotations for SFI1
Molecular Function
    protein binding GO:0005515 IPI
    phosphatase binding GO:0019902 IDA
Biological Process
    negative regulation of phosphatase activity GO:0010923 IDA
    mitotic cell cycle GO:0000278 TAS
    G2/M transition of mitotic cell cycle GO:0000086 TAS
    organelle organization GO:0006996 TAS
Subcellular Localization
    cytosol GO:0005829 TAS
    centriole GO:0005814 IEA
 Experiment description of studies that identified SFI1 in exosomes
1
Experiment ID 52
MISEV standards
✔
EM
EV Biophysical techniques
✔
HSP90|MHCII
EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 14975938    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes isolated from human malignant pleural effusions.
Authors Bard MP, Hegmans JP, Hemmes A, Luider TM, Willemsen R, Severijnen LA, van Meerbeeck JP, Burgers SA, Hoogsteden HC, Lambrecht BN
Journal name AJRCMB
Publication year 2004
Sample Malignant pleural effusions
Sample name Pleural Fluid - Lung cancer
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
 Protein-protein interactions for SFI1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 KRT19 3880
Two-hybrid Homo sapiens
2 FLJ10324  
Two-hybrid Homo sapiens
3 MDFI  
Two-hybrid Homo sapiens
4 CETN2 1069
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
View the network image/svg+xml



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