Gene description for NUP160
Gene name nucleoporin 160kDa
Gene symbol NUP160
Other names/aliases -
Species Homo sapiens
 Database cross references - NUP160
ExoCarta ExoCarta_23279
Vesiclepedia VP_23279
Entrez Gene 23279
HGNC 18017
MIM 607614
UniProt Q12769  
 NUP160 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
Thymus 23844026    
 Gene ontology annotations for NUP160
Molecular Function
    protein binding GO:0005515 IPI
    structural constituent of nuclear pore GO:0017056 IBA
    structural constituent of nuclear pore GO:0017056 IDA
Biological Process
    mRNA export from nucleus GO:0006406 IDA
    nucleocytoplasmic transport GO:0006913 NAS
    protein transport GO:0015031 IEA
    nephron development GO:0072006 IMP
Subcellular Localization
    kinetochore GO:0000776 IDA
    nuclear envelope GO:0005635 IDA
    nuclear envelope GO:0005635 TAS
    nuclear pore GO:0005643 IBA
    nuclear pore GO:0005643 IDA
    nuclear pore GO:0005643 NAS
    cytosol GO:0005829 TAS
    nuclear pore outer ring GO:0031080 IDA
    nuclear pore outer ring GO:0031080 NAS
 Experiment description of studies that identified NUP160 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for NUP160
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SLFN11 91607
Affinity Capture-MS Homo sapiens
2 RIT1 6016
Negative Genetic Homo sapiens
3 HSD17B11 51170
Proximity Label-MS Homo sapiens
4 METTL7A 25840
Proximity Label-MS Homo sapiens
5 NUP62 23636
Co-fractionation Homo sapiens
6 KPNB1 3837
Affinity Capture-MS Homo sapiens
7 TMEM206 55248
Affinity Capture-MS Homo sapiens
8 C9orf78 51759
Affinity Capture-MS Homo sapiens
9 NUMA1 4926
Affinity Capture-MS Homo sapiens
10 PTPN1 5770
Proximity Label-MS Homo sapiens
11 PNKD  
Affinity Capture-MS Homo sapiens
12 CENPA  
Proximity Label-MS Homo sapiens
13 KIAA1429 25962
Affinity Capture-MS Homo sapiens
14 UXS1 80146
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 RAF1 5894
Affinity Capture-MS Homo sapiens
16 NUP153 9972
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
17 ESRRG  
Two-hybrid Homo sapiens
18 PRC1 9055
Affinity Capture-MS Homo sapiens
19 SSR1 6745
Proximity Label-MS Homo sapiens
20 OBSL1 23363
Affinity Capture-MS Homo sapiens
21 ARID1A 8289
Negative Genetic Homo sapiens
22 EXD2  
Proximity Label-MS Homo sapiens
23 TACSTD2 4070
Affinity Capture-MS Homo sapiens
24 SEH1L 81929
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
25 SLC25A46 91137
Proximity Label-MS Homo sapiens
26 RAB35 11021
Proximity Label-MS Homo sapiens
27 CA14 23632
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 FOXP3  
Affinity Capture-MS Homo sapiens
29 MICA 100507436
Affinity Capture-MS Homo sapiens
30 NUP155 9631
Proximity Label-MS Homo sapiens
31 CHMP4C 92421
Affinity Capture-MS Homo sapiens
32 CD70 970
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 LMNB1 4001
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 USP12 219333
Affinity Capture-MS Homo sapiens
35 Rcc1  
Affinity Capture-MS Mus musculus
36 EMD 2010
Proximity Label-MS Homo sapiens
37 FOXI2  
Affinity Capture-MS Homo sapiens
38 MAPRE1 22919
Affinity Capture-MS Homo sapiens
39 COMTD1 118881
Affinity Capture-MS Homo sapiens
40 NTRK1 4914
Affinity Capture-MS Homo sapiens
41 DTX2 113878
Proximity Label-MS Homo sapiens
42 CLSTN2 64084
Affinity Capture-MS Homo sapiens
43 XPOT 11260
Co-fractionation Homo sapiens
44 RPN1 6184
Proximity Label-MS Homo sapiens
45 EED  
Affinity Capture-MS Homo sapiens
46 Ube2i  
Affinity Capture-MS Mus musculus
47 LATS2 26524
Proximity Label-MS Homo sapiens
48 ELOVL5 60481
Proximity Label-MS Homo sapiens
49 SEC61B 10952
Proximity Label-MS Homo sapiens
50 MLNR  
Affinity Capture-MS Homo sapiens
51 ANLN 54443
Affinity Capture-MS Homo sapiens
52 DISC1 27185
Two-hybrid Homo sapiens
53 CD40 958
Affinity Capture-MS Homo sapiens
54 GAN 8139
Affinity Capture-MS Homo sapiens
55 NUP37 79023
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
56 RPN2 6185
Proximity Label-MS Homo sapiens
57 Nup98  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
58 SIGLECL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 BTNL9  
Affinity Capture-MS Homo sapiens
60 XPO1 7514
Affinity Capture-MS Homo sapiens
61 EGLN3  
Affinity Capture-MS Homo sapiens
62 TPR 7175
Co-fractionation Homo sapiens
63 SEC13 6396
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 SIRT7  
Affinity Capture-MS Homo sapiens
65 HSD3B7 80270
Proximity Label-MS Homo sapiens
66 CUL3 8452
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 FKBP8 23770
Proximity Label-MS Homo sapiens
68 NUP43 348995
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
69 NUP214 8021
Affinity Capture-MS Homo sapiens
70 FKBP5 2289
Affinity Capture-MS Homo sapiens
71 Nup107  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
72 RPA3 6119
Proximity Label-MS Homo sapiens
73 USP19 10869
Affinity Capture-MS Homo sapiens
74 SART3 9733
Affinity Capture-MS Homo sapiens
75 SPAST 6683
Affinity Capture-MS Homo sapiens
76 SCN2B  
Affinity Capture-MS Homo sapiens
77 RANBP1 5902
Affinity Capture-MS Homo sapiens
78 RHOB 388
Proximity Label-MS Homo sapiens
79 FOXQ1  
Affinity Capture-MS Homo sapiens
80 CETN2 1069
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
81 Ostm1  
Affinity Capture-MS Mus musculus
82 HUWE1 10075
Affinity Capture-MS Homo sapiens
83 ZRANB1 54764
Affinity Capture-MS Homo sapiens
84 KRT18 3875
Proximity Label-MS Homo sapiens
85 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
86 ZNF785  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
87 SIRT6  
Affinity Capture-MS Homo sapiens
88 NUP133 55746
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
89 TP53 7157
Affinity Capture-MS Homo sapiens
90 ZNF746  
Affinity Capture-MS Homo sapiens
91 FOXB1  
Affinity Capture-MS Homo sapiens
92 PBRM1 55193
Negative Genetic Homo sapiens
93 AHCTF1 25909
Two-hybrid Homo sapiens
94 NUP35 129401
Proximity Label-MS Homo sapiens
95 RGPD1  
Affinity Capture-MS Homo sapiens
96 Nup214  
Affinity Capture-MS Mus musculus
97 NUP107 57122
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
98 MAGED1 9500
Affinity Capture-MS Homo sapiens
99 SPN 6693
Affinity Capture-MS Homo sapiens
100 SEC62 7095
Proximity Label-MS Homo sapiens
101 Ranbp2  
Affinity Capture-MS Mus musculus
102 TPST2 8459
Affinity Capture-MS Homo sapiens
103 CUL7 9820
Affinity Capture-MS Homo sapiens
104 KRAS 3845
Negative Genetic Homo sapiens
105 C9orf72  
Affinity Capture-MS Homo sapiens
106 VASN 114990
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
107 NUP85 79902
Co-fractionation Homo sapiens
108 PLD6  
Affinity Capture-MS Homo sapiens
109 EXOSC1 51013
Two-hybrid Homo sapiens
110 RANBP2 5903
Co-fractionation Homo sapiens
111 DERL1 79139
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which NUP160 is involved
PathwayEvidenceSource
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal TAS Reactome
Amplification of signal from the kinetochores TAS Reactome
Antiviral mechanism by IFN-stimulated genes TAS Reactome
Cell Cycle TAS Reactome
Cell Cycle IEA Reactome
Cell Cycle Checkpoints TAS Reactome
Cell Cycle, Mitotic TAS Reactome
Cell Cycle, Mitotic IEA Reactome
Cellular response to heat stress TAS Reactome
Cellular responses to stimuli TAS Reactome
Cellular responses to stress TAS Reactome
Cytokine Signaling in Immune system TAS Reactome
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) TAS Reactome
Disease TAS Reactome
Disease IEA Reactome
Disorders of transmembrane transporters TAS Reactome
EML4 and NUDC in mitotic spindle formation TAS Reactome
Export of Viral Ribonucleoproteins from Nucleus TAS Reactome
Gene expression (Transcription) TAS Reactome
Gene Silencing by RNA TAS Reactome
Glucose metabolism TAS Reactome
Glycolysis TAS Reactome
HCMV Early Events TAS Reactome
HCMV Infection TAS Reactome
HCMV Late Events TAS Reactome
HIV Infection IEA Reactome
HIV Infection TAS Reactome
HIV Life Cycle TAS Reactome
Host Interactions of HIV factors IEA Reactome
Host Interactions of HIV factors TAS Reactome
Immune System TAS Reactome
Infectious disease TAS Reactome
Infectious disease IEA Reactome
Influenza Infection TAS Reactome
Influenza Viral RNA Transcription and Replication TAS Reactome
Interactions of Rev with host cellular proteins IEA Reactome
Interactions of Rev with host cellular proteins TAS Reactome
Interactions of Vpr with host cellular proteins TAS Reactome
Interferon Signaling TAS Reactome
ISG15 antiviral mechanism TAS Reactome
Late Phase of HIV Life Cycle TAS Reactome
M Phase TAS Reactome
M Phase IEA Reactome
Metabolism TAS Reactome
Metabolism of carbohydrates TAS Reactome
Metabolism of non-coding RNA TAS Reactome
Metabolism of proteins TAS Reactome
Metabolism of proteins IEA Reactome
Metabolism of RNA TAS Reactome
Mitotic Anaphase TAS Reactome
Mitotic Anaphase IEA Reactome
Mitotic Metaphase and Anaphase TAS Reactome
Mitotic Metaphase and Anaphase IEA Reactome
Mitotic Prometaphase TAS Reactome
Mitotic Prophase TAS Reactome
Mitotic Spindle Checkpoint TAS Reactome
NEP/NS2 Interacts with the Cellular Export Machinery TAS Reactome
NS1 Mediated Effects on Host Pathways TAS Reactome
Nuclear Envelope (NE) Reassembly TAS Reactome
Nuclear Envelope (NE) Reassembly IEA Reactome
Nuclear Envelope Breakdown TAS Reactome
Nuclear import of Rev protein IEA Reactome
Nuclear Pore Complex (NPC) Disassembly TAS Reactome
Post-translational protein modification TAS Reactome
Post-translational protein modification IEA Reactome
Postmitotic nuclear pore complex (NPC) reformation TAS Reactome
Postmitotic nuclear pore complex (NPC) reformation IEA Reactome
Processing of Capped Intron-Containing Pre-mRNA TAS Reactome
Regulation of Glucokinase by Glucokinase Regulatory Protein TAS Reactome
Regulation of HSF1-mediated heat shock response TAS Reactome
Resolution of Sister Chromatid Cohesion TAS Reactome
Rev-mediated nuclear export of HIV RNA TAS Reactome
RHO GTPase Effectors TAS Reactome
RHO GTPases Activate Formins TAS Reactome
SARS-CoV Infections TAS Reactome
SARS-CoV-2 activates/modulates innate and adaptive immune responses TAS Reactome
SARS-CoV-2 Infection TAS Reactome
SARS-CoV-2-host interactions TAS Reactome
Separation of Sister Chromatids TAS Reactome
Signal Transduction TAS Reactome
Signaling by Rho GTPases TAS Reactome
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 TAS Reactome
SLC transporter disorders TAS Reactome
snRNP Assembly TAS Reactome
SUMO E3 ligases SUMOylate target proteins TAS Reactome
SUMO E3 ligases SUMOylate target proteins IEA Reactome
SUMOylation TAS Reactome
SUMOylation IEA Reactome
SUMOylation of chromatin organization proteins TAS Reactome
SUMOylation of DNA damage response and repair proteins TAS Reactome
SUMOylation of DNA replication proteins IEA Reactome
SUMOylation of DNA replication proteins TAS Reactome
SUMOylation of RNA binding proteins TAS Reactome
SUMOylation of SUMOylation proteins TAS Reactome
SUMOylation of ubiquitinylation proteins TAS Reactome
Transcriptional regulation by small RNAs TAS Reactome
Transport of Mature mRNA derived from an Intron-Containing Transcript TAS Reactome
Transport of Mature mRNA Derived from an Intronless Transcript TAS Reactome
Transport of Mature mRNAs Derived from Intronless Transcripts TAS Reactome
Transport of Mature Transcript to Cytoplasm TAS Reactome
Transport of Ribonucleoproteins into the Host Nucleus TAS Reactome
Transport of the SLBP Dependant Mature mRNA TAS Reactome
Transport of the SLBP independent Mature mRNA TAS Reactome
tRNA processing TAS Reactome
tRNA processing in the nucleus TAS Reactome
Viral Infection Pathways TAS Reactome
Viral Infection Pathways IEA Reactome
Viral Messenger RNA Synthesis TAS Reactome
Vpr-mediated nuclear import of PICs TAS Reactome





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