Gene description for TRIM35
Gene name tripartite motif containing 35
Gene symbol TRIM35
Other names/aliases HLS5
MAIR
Species Homo sapiens
 Database cross references - TRIM35
ExoCarta ExoCarta_23087
Entrez Gene 23087
HGNC 16285
UniProt Q9UPQ4  
 TRIM35 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for TRIM35
Molecular Function
    molecular_function GO:0003674 ND
    zinc ion binding GO:0008270 IEA
Biological Process
    apoptotic process GO:0006915 ISS
    positive regulation of apoptotic process GO:0043065 IDA
    negative regulation of viral release from host cell GO:1902187 IDA
    innate immune response GO:0045087 IDA
    negative regulation of mitotic cell cycle GO:0045930 IDA
    negative regulation of cell proliferation GO:0008285 IEA
Subcellular Localization
    nucleus GO:0005634 ISS
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 ISS
 Experiment description of studies that identified TRIM35 in exosomes
1
Experiment ID 237
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for TRIM35
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which TRIM35 is involved
PathwayEvidenceSource
Interferon gamma signaling TAS Reactome





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