Gene description for USP34
Gene name ubiquitin specific peptidase 34
Gene symbol USP34
Other names/aliases -
Species Homo sapiens
 Database cross references - USP34
ExoCarta ExoCarta_9736
Vesiclepedia VP_9736
Entrez Gene 9736
HGNC 20066
MIM 615295
UniProt Q70CQ2  
 USP34 identified in exosomes derived from the following tissue/cell type
Endothelial cells 26027894    
 Gene ontology annotations for USP34
Molecular Function
    cysteine-type endopeptidase activity GO:0004197 IMP
    cysteine-type deubiquitinase activity GO:0004843 IBA
    cysteine-type deubiquitinase activity GO:0004843 IDA
    cysteine-type deubiquitinase activity GO:0004843 TAS
    protein binding GO:0005515 IPI
Biological Process
    proteolysis GO:0006508 IEA
    Wnt signaling pathway GO:0016055 TAS
    protein deubiquitination GO:0016579 TAS
    regulation of protein stability GO:0031647 IBA
    protein K48-linked deubiquitination GO:0071108 IDA
    positive regulation of canonical Wnt signaling pathway GO:0090263 IDA
Subcellular Localization
    nucleus GO:0005634 IBA
    cytosol GO:0005829 IBA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified USP34 in exosomes
1
Experiment ID 226
MISEV standards
EM
Biophysical techniques
GAPDH|CD9|FLOT1
Enriched markers
LMNA|H2AFX|ATP5A1|TOMM20
Negative markers
Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description "Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting"
Authors "Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar"
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
 Protein-protein interactions for USP34
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ATP6V1B2 526
Co-fractionation Homo sapiens
2 ZNF211  
Affinity Capture-MS Homo sapiens
3 ZNF514  
Affinity Capture-MS Homo sapiens
4 CSNK1A1 1452
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 DNAJB2 3300
Affinity Capture-MS Homo sapiens
6 CD2AP 23607
Co-fractionation Homo sapiens
7 HDHD1  
Affinity Capture-MS Homo sapiens
8 USP9X 8239
Co-fractionation Homo sapiens
9 ZNF354C  
Affinity Capture-MS Homo sapiens
10 ATM 472
Affinity Capture-Western Homo sapiens
11 LOXL4 84171
Affinity Capture-MS Homo sapiens
12 DPPA4  
Affinity Capture-MS Homo sapiens
13 MESP2  
Affinity Capture-MS Homo sapiens
14 RBM3 5935
Affinity Capture-MS Homo sapiens
15 TRIM35 23087
Affinity Capture-MS Homo sapiens
16 SUV39H1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 POU5F1  
Affinity Capture-MS Homo sapiens
18 ZNF460  
Affinity Capture-MS Homo sapiens
19 GAB2 9846
Affinity Capture-MS Homo sapiens
20 UBQLN1 29979
Co-fractionation Homo sapiens
21 EPHA1 2041
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 VPS4B 9525
Co-fractionation Homo sapiens
23 ERMAP 114625
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 UCHL3 7347
Co-fractionation Homo sapiens
25 ZNF418  
Affinity Capture-MS Homo sapiens
26 UBQLN4 56893
Co-fractionation Homo sapiens
27 C9orf163  
Affinity Capture-MS Homo sapiens
28 AHCYL1 10768
Co-fractionation Homo sapiens
29 MTNR1B  
Two-hybrid Homo sapiens
30 UBE2V1 7335
Co-fractionation Homo sapiens
31 UNK  
Co-fractionation Homo sapiens
32 ZNF550  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 SRP9 6726
Affinity Capture-MS Homo sapiens
34 UBE4B 10277
Co-fractionation Homo sapiens
35 B4GALT2  
Affinity Capture-MS Homo sapiens
36 DNAJB8  
Affinity Capture-MS Homo sapiens
37 SNRNP200 23020
Co-fractionation Homo sapiens
38 FOXD4L6  
Affinity Capture-MS Homo sapiens
39 BCL2L12 83596
Affinity Capture-MS Homo sapiens
40 ENTPD1 953
Affinity Capture-MS Homo sapiens
41 UBQLN2 29978
Co-fractionation Homo sapiens
42 PPARD  
Affinity Capture-MS Homo sapiens
43 DTX2 113878
Proximity Label-MS Homo sapiens
44 RPA4  
Proximity Label-MS Homo sapiens
45 PML 5371
Affinity Capture-MS Homo sapiens
46 LYPD4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 KIAA1033 23325
Co-fractionation Homo sapiens
48 LRRTM4  
Affinity Capture-MS Homo sapiens
49 HSPB8 26353
Affinity Capture-MS Homo sapiens
50 UBXN6 80700
Affinity Capture-MS Homo sapiens
51 UPP1 7378
Affinity Capture-MS Homo sapiens
52 STAM 8027
Co-fractionation Homo sapiens
53 C11orf71  
Affinity Capture-MS Homo sapiens
54 C1orf111  
Affinity Capture-MS Homo sapiens
55 UFC1 51506
Co-fractionation Homo sapiens
56 FGF14  
Affinity Capture-MS Homo sapiens
57 BTNL9  
Affinity Capture-MS Homo sapiens
58 SRXN1 140809
Co-fractionation Homo sapiens
59 SIRT7  
Affinity Capture-MS Homo sapiens
60 UBXN7 26043
Co-fractionation Homo sapiens
61 UBE2L3 7332
Co-fractionation Homo sapiens
62 CYBB 1536
Affinity Capture-MS Homo sapiens
63 UBC 7316
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
64 CUL3 8452
Affinity Capture-MS Homo sapiens
65 MTNR1A  
Two-hybrid Homo sapiens
66 EGFR 1956
Affinity Capture-MS Homo sapiens
67 METTL21B  
Affinity Capture-MS Homo sapiens
68 ZFYVE19 84936
Co-fractionation Homo sapiens
69 ELP2 55250
Co-fractionation Homo sapiens
70 TAGLN 6876
Affinity Capture-MS Homo sapiens
71 OCIAD1 54940
Affinity Capture-MS Homo sapiens
72 AGO4  
Affinity Capture-MS Homo sapiens
73 TSPAN8 7103
Affinity Capture-MS Homo sapiens
74 C12orf74  
Affinity Capture-MS Homo sapiens
75 UBA2 10054
Co-fractionation Homo sapiens
76 RPA3 6119
Proximity Label-MS Homo sapiens
77 SOHLH1  
Affinity Capture-MS Homo sapiens
78 UBL7  
Co-fractionation Homo sapiens
79 PCGF1 84759
Affinity Capture-MS Homo sapiens
80 NANOG  
Affinity Capture-MS Homo sapiens
81 HIST1H1T 3010
Affinity Capture-MS Homo sapiens
82 UBXN1 51035
Co-fractionation Homo sapiens
83 HUWE1 10075
Affinity Capture-MS Homo sapiens
84 UBE2D1 7321
Co-fractionation Homo sapiens
85 C6orf222  
Affinity Capture-MS Homo sapiens
86 ZRANB1 54764
Affinity Capture-MS Homo sapiens
87 ZNF669  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
88 ZNF707  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
89 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
90 SEC24A 10802
Co-fractionation Homo sapiens
91 ZNF785  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
92 ZRANB2 9406
Co-fractionation Homo sapiens
93 TSPYL6  
Affinity Capture-MS Homo sapiens
94 C15orf53  
Affinity Capture-MS Homo sapiens
95 SULT1A1 6817
Co-fractionation Homo sapiens
96 CTAG1B  
Affinity Capture-MS Homo sapiens
97 UBE2C 11065
Co-fractionation Homo sapiens
98 FAM83F 113828
Affinity Capture-MS Homo sapiens
99 ZNF764 92595
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
100 NUP35 129401
Proximity Label-MS Homo sapiens
101 DDX58 23586
Affinity Capture-RNA Homo sapiens
102 ZEB1  
Affinity Capture-MS Homo sapiens
103 HOXB1  
Affinity Capture-MS Homo sapiens
104 LAGE3  
Co-fractionation Homo sapiens
105 GLUL 2752
Affinity Capture-MS Homo sapiens
106 INF2 64423
Affinity Capture-MS Homo sapiens
107 C16orf72 29035
Affinity Capture-MS Homo sapiens
108 ZNF214  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
109 SSSCA1 10534
Co-fractionation Homo sapiens
110 ZNF10  
Affinity Capture-MS Homo sapiens
111 BRD1 23774
Affinity Capture-MS Homo sapiens
112 RPP21  
Affinity Capture-MS Homo sapiens
113 EIF3M 10480
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
114 TTLL12 23170
Co-fractionation Homo sapiens
115 UBE2V2 7336
Co-fractionation Homo sapiens
116 UFM1 51569
Co-fractionation Homo sapiens
View the network image/svg+xml



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