Gene description for CYBB
Gene name	cytochrome b-245, beta polypeptide
Gene symbol	CYBB
Other names/aliases	AMCBX2 CGD GP91-1 GP91-PHOX GP91PHOX IMD34 NOX2 p91-PHOX
Species	Homo sapiens
Database cross references - CYBB
ExoCarta	ExoCarta_1536
Entrez Gene	1536
HGNC	2578
MIM	300481
UniProt	P04839
CYBB identified in exosomes derived from the following tissue/cell type
Thymus	23844026

Gene ontology annotations for CYBB

Molecular Function     voltage-gated ion channel activity GO:0005244 IEA     superoxide-generating NADPH oxidase activity GO:0016175 TAS     protein binding GO:0005515 IPI     metal ion binding GO:0046872 IEA     flavin adenine dinucleotide binding GO:0050660 IMP     electron carrier activity GO:0009055 IDA     heme binding GO:0020037 IMP     protein heterodimerization activity GO:0046982 IPI Biological Process     ion transport GO:0006811 IEA     innate immune response GO:0045087 TAS     antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 TAS     response to nutrient GO:0007584 IEA     antigen processing and presentation of exogenous peptide antigen via MHC class I GO:0042590 TAS     hydrogen peroxide biosynthetic process GO:0050665 IEA     response to drug GO:0042493 IEA     antigen processing and presentation of peptide antigen via MHC class I GO:0002474 TAS     phagosome maturation GO:0090382 TAS     superoxide metabolic process GO:0006801 TAS     small GTPase mediated signal transduction GO:0007264 TAS     interaction with host GO:0051701 TAS     respiratory burst GO:0045730 TAS     superoxide anion generation GO:0042554 TAS     inflammatory response GO:0006954 ISS     vascular endothelial growth factor receptor signaling pathway GO:0048010 TAS     oxidation-reduction process GO:0055114 TAS     regulation of ion transmembrane transport GO:0034765 IEA Subcellular Localization     neuronal cell body GO:0043025 IEA     Golgi apparatus GO:0005794 IEA     mitochondrion GO:0005739 IEA     NADPH oxidase complex GO:0043020 TAS     rough endoplasmic reticulum GO:0005791 IEA     plasma membrane GO:0005886 TAS     phagocytic vesicle membrane GO:0030670 TAS     dendrite GO:0030425 IEA     integral component of plasma membrane GO:0005887 IDA