Gene description for SLC30A1
Gene name solute carrier family 30 (zinc transporter), member 1
Gene symbol SLC30A1
Other names/aliases ZNT1
ZRC1
Species Homo sapiens
 Database cross references - SLC30A1
ExoCarta ExoCarta_7779
Entrez Gene 7779
HGNC 11012
MIM 609521
UniProt Q9Y6M5  
 SLC30A1 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for SLC30A1
Molecular Function
    calcium channel inhibitor activity GO:0019855 ISS
    zinc ion transmembrane transporter activity GO:0005385 IEA
    protein binding GO:0005515 IPI
Biological Process
    transmembrane transport GO:0055085 TAS
    negative regulation of neurotransmitter secretion GO:0046929 ISS
    cellular zinc ion homeostasis GO:0006882 ISS
    detoxification of cadmium ion GO:0071585 IEA
    cadmium ion transmembrane transport GO:0070574 ISS
    in utero embryonic development GO:0001701 IEA
    negative regulation of calcium ion import GO:0090281 ISS
    calcium ion import GO:0070509 IEA
    zinc II ion transport GO:0006829 ISS
    negative regulation of zinc ion transmembrane import GO:0071584 ISS
    cellular calcium ion homeostasis GO:0006874 ISS
    zinc II ion transmembrane transport GO:0071577 IEA
Subcellular Localization
    integral component of membrane GO:0016021 IEA
    cytoplasm GO:0005737 IDA
    Golgi apparatus GO:0005794 IDA
    nuclear membrane GO:0031965 IDA
    endoplasmic reticulum GO:0005783 IDA
    T-tubule GO:0030315 ISS
    plasma membrane GO:0005886 TAS
 Experiment description of studies that identified SLC30A1 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
2
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SLC30A1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SLC30A1 is involved
PathwayEvidenceSource
Zinc efflux and compartmentalization by the SLC30 family TAS Reactome





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