ExoCarta: Gene summary

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Gene description for GALNT6
Gene name	polypeptide N-acetylgalactosaminyltransferase 6
Gene symbol	GALNT6
Other names/aliases	GALNAC-T6 GalNAcT6
Species	Homo sapiens
Database cross references - GALNT6
ExoCarta	ExoCarta_11226
Vesiclepedia	VP_11226
Entrez Gene	11226
HGNC	4128
MIM	605148
UniProt	Q8NCL4
GALNT6 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells	34887515

Gene ontology annotations for GALNT6

Molecular Function
	polypeptide N-acetylgalactosaminyltransferase activity	GO:0004653	IEA
	metal ion binding	GO:0046872	IEA
	carbohydrate binding	GO:0030246	IEA
Biological Process
	protein O-linked glycosylation	GO:0006493	TAS
	O-glycan processing	GO:0016266	TAS
	cellular protein metabolic process	GO:0044267	TAS
	post-translational protein modification	GO:0043687	TAS
Subcellular Localization
	integral component of membrane	GO:0016021	IEA
	Golgi membrane	GO:0000139	TAS
	perinuclear region of cytoplasm	GO:0048471	IDA
	Golgi apparatus	GO:0005794	IDA

Experiment description of studies that identified GALNT6 in exosomes

Experiment ID

1203

MISEV standards
✔ EM	EV Biophysical techniques
✔ SDCBP\|FLOT1\|CD9\|CD81\|CD63\|EPCAM\|GAPDH\|LAMP1\|TFRC\|CD151\|CD82\|LAMP2\|RAB35\|TSG101\|FLOT2\|RAB5B\|ICAM1\|RAB5A	EV Enriched markers
✘	EV Negative markers
✘	EV Particle analysis

Identified molecule

protein

Identification method

Mass spectrometry

PubMed ID

34887515

Organism

Homo sapiens

Experiment description

Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets

Authors

Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ.

Journal name

Nat Cell Biol

Publication year

2021

Sample

Colorectal cancer cells

Sample name

DiFi

Isolation/purification methods

Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation

Flotation density

Molecules identified in the study

Protein
miRNA

Methods used in the study

Western blotting
Mass spectrometry
RNA sequencing

Protein-protein interactions for GALNT6

	Protein Interactor	ExoCarta ID	Identification method	PubMed	Species
No interactions are found.

Pathways in which GALNT6 is involved

Pathway	Evidence	Source
O-linked glycosylation of mucins	TAS	Reactome

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