Gene description for GALNT6
Gene name polypeptide N-acetylgalactosaminyltransferase 6
Gene symbol GALNT6
Other names/aliases GALNAC-T6
GalNAcT6
Species Homo sapiens
 Database cross references - GALNT6
ExoCarta ExoCarta_11226
Vesiclepedia VP_11226
Entrez Gene 11226
HGNC 4128
MIM 605148
UniProt Q8NCL4  
 GALNT6 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 34887515    
 Gene ontology annotations for GALNT6
Molecular Function
    polypeptide N-acetylgalactosaminyltransferase activity GO:0004653 IBA
    polypeptide N-acetylgalactosaminyltransferase activity GO:0004653 IDA
    polypeptide N-acetylgalactosaminyltransferase activity GO:0004653 TAS
    protein binding GO:0005515 IPI
    carbohydrate binding GO:0030246 IEA
    metal ion binding GO:0046872 IEA
Biological Process
    protein O-linked glycosylation GO:0006493 IBA
    O-glycan processing GO:0016266 TAS
    protein O-linked glycosylation via threonine GO:0018243 IDA
Subcellular Localization
    Golgi membrane GO:0000139 TAS
    Golgi apparatus GO:0005794 IBA
    Golgi apparatus GO:0005794 IDA
    perinuclear region of cytoplasm GO:0048471 IDA
 Experiment description of studies that identified GALNT6 in exosomes
1
Experiment ID 1203
MISEV standards
✔
EM
Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
 Protein-protein interactions for GALNT6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ATP2B3 492
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 CCL3  
Affinity Capture-MS Homo sapiens
3 FDXACB1  
Affinity Capture-MS Homo sapiens
4 SLC39A10 57181
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 BTNL2  
Affinity Capture-MS Homo sapiens
6 RAP1GDS1 5910
Affinity Capture-MS Homo sapiens
7 PLXNA2 5362
Affinity Capture-MS Homo sapiens
8 TMEM9 252839
Two-hybrid Homo sapiens
9 NDST2  
Affinity Capture-MS Homo sapiens
10 RHOBTB3 22836
Affinity Capture-MS Homo sapiens
11 KIF20A 10112
Affinity Capture-MS Homo sapiens
12 ATP2B2 491
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 NDUFB5 4711
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 SLC30A1 7779
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 EDDM3A  
Affinity Capture-MS Homo sapiens
16 PDGFRA 5156
Affinity Capture-MS Homo sapiens
17 EDEM1  
Affinity Capture-MS Homo sapiens
18 NDUFS4 4724
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 GOLPH3 64083
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
20 RMND1 55005
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 NDUFA12 55967
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 SLC5A6 8884
Two-hybrid Homo sapiens
23 FBXO6 26270
Affinity Capture-MS Homo sapiens
24 NDUFB6 4712
Affinity Capture-MS Homo sapiens
25 FAM20B 9917
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 NDUFB9 4715
Affinity Capture-MS Homo sapiens
27 SFTPC  
Affinity Capture-MS Homo sapiens
28 LGALS3BP 3959
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
29 EMR4P  
Affinity Capture-MS Homo sapiens
30 GOLPH3L 55204
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
31 TAF9 6880
Two-hybrid Homo sapiens
32 NDUFB3 4709
Affinity Capture-MS Homo sapiens
33 NDUFB8 4714
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 SCGB2A2  
Affinity Capture-MS Homo sapiens
35 C1orf54  
Affinity Capture-MS Homo sapiens
36 NDUFAF6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 ASPHD2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 SCGB2A1 4246
Affinity Capture-MS Homo sapiens
39 SLC9A1 6548
Affinity Capture-MS Homo sapiens
40 B4GALT3 8703
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 HTR1B  
Affinity Capture-MS Homo sapiens
42 BAGE2  
Affinity Capture-MS Homo sapiens
43 ST14 6768
Affinity Capture-MS Homo sapiens
44 GAS6 2621
Affinity Capture-MS Homo sapiens
45 NDUFS6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 ALDOA 226
Two-hybrid Homo sapiens
View the network image/svg+xml



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