Gene description for TNFSF12
Gene name tumor necrosis factor (ligand) superfamily, member 12
Gene symbol TNFSF12
Other names/aliases APO3L
DR3LG
TWEAK
Species Homo sapiens
 Database cross references - TNFSF12
ExoCarta ExoCarta_8742
Vesiclepedia VP_8742
Entrez Gene 8742
HGNC 11927
MIM 602695
UniProt O43508  
 TNFSF12 identified in exosomes derived from the following tissue/cell type
Saliva 19199708    
 Gene ontology annotations for TNFSF12
Molecular Function
    receptor binding GO:0005102 TAS
    protein binding GO:0005515 IPI
    tumor necrosis factor receptor binding GO:0005164 IEA
    cytokine activity GO:0005125 TAS
Biological Process
    apoptotic process GO:0006915 IEA
    positive regulation of endothelial cell proliferation GO:0001938 TAS
    endothelial cell migration GO:0043542 TAS
    signal transduction GO:0007165 TAS
    immune response GO:0006955 IEA
    positive regulation of extrinsic apoptotic signaling pathway GO:2001238 IDA
    apoptotic signaling pathway GO:0097190 TAS
    positive regulation of protein catabolic process GO:0045732 IDA
    cell differentiation GO:0030154 IEA
    angiogenesis GO:0001525 IEA
    positive regulation of angiogenesis GO:0045766 TAS
Subcellular Localization
    integral component of plasma membrane GO:0005887 TAS
    extracellular space GO:0005615 TAS
    perinuclear region of cytoplasm GO:0048471 IDA
 Experiment description of studies that identified TNFSF12 in exosomes
1
Experiment ID 66
MISEV standards
✔
IEM
EV Biophysical techniques
✔
TSG101|Alix|CD63|CD81
EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for TNFSF12
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 AGGF1  
Affinity Capture-MS Homo sapiens
2 TNFRSF12A 51330
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TNFSF12 is involved
No pathways found





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