Gene description for PRPH2
Gene name peripherin 2 (retinal degeneration, slow)
Gene symbol PRPH2
Other names/aliases AOFMD
AVMD
CACD2
DS
MDBS1
PRPH
RDS
RP7
TSPAN22
rd2
Species Homo sapiens
 Database cross references - PRPH2
ExoCarta ExoCarta_5961
Vesiclepedia VP_5961
Entrez Gene 5961
HGNC 9942
MIM 179605
UniProt P23942  
 PRPH2 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for PRPH2
Molecular Function
    protein binding GO:0005515 IPI
    protein homodimerization activity GO:0042803 IEA
Biological Process
    cell adhesion GO:0007155 IEA
    visual perception GO:0007601 TAS
    response to low light intensity stimulus GO:0009645 IEA
    photoreceptor cell outer segment organization GO:0035845 IEA
    detection of light stimulus involved in visual perception GO:0050908 IEA
    protein homooligomerization GO:0051260 IEA
    protein heterooligomerization GO:0051291 IEA
    protein maturation GO:0051604 IBA
    retina development in camera-type eye GO:0060041 IEA
    protein localization to plasma membrane GO:0072659 IBA
Subcellular Localization
    photoreceptor outer segment GO:0001750 IEA
    photoreceptor inner segment GO:0001917 IEA
    plasma membrane GO:0005886 IBA
    membrane GO:0016020 TAS
 Experiment description of studies that identified PRPH2 in exosomes
1
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PRPH2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HSPE1 3336
Affinity Capture-MS Homo sapiens
2 PVRL2 5819
Affinity Capture-MS Homo sapiens
3 TOR1A 1861
Affinity Capture-MS Homo sapiens
4 SLMAP 7871
Affinity Capture-MS Homo sapiens
5 RAB9B 51209
Affinity Capture-MS Homo sapiens
6 SLC30A1 7779
Affinity Capture-MS Homo sapiens
7 HMOX2 3163
Affinity Capture-MS Homo sapiens
8 MPZL1 9019
Affinity Capture-MS Homo sapiens
9 NCAM1 4684
Affinity Capture-MS Homo sapiens
10 EXTL2 2135
Affinity Capture-MS Homo sapiens
11 CPNE9  
Affinity Capture-MS Homo sapiens
12 PODXL2 50512
Affinity Capture-MS Homo sapiens
13 ITPRIP  
Affinity Capture-MS Homo sapiens
14 CD59 966
Affinity Capture-MS Homo sapiens
15 NUP35 129401
Affinity Capture-MS Homo sapiens
16 PTPRS 5802
Affinity Capture-MS Homo sapiens
17 POMGNT2  
Affinity Capture-MS Homo sapiens
18 POTEE 445582
Affinity Capture-MS Homo sapiens
19 UBB 7314
Affinity Capture-MS Homo sapiens
20 TNFRSF10B 8795
Affinity Capture-MS Homo sapiens
21 RAET1L  
Affinity Capture-MS Homo sapiens
22 NRAS 4893
Affinity Capture-MS Homo sapiens
23 CSTF3 1479
Affinity Capture-MS Homo sapiens
24 SLC9A3R1 9368
Affinity Capture-MS Homo sapiens
25 ACSL6 23305
Affinity Capture-MS Homo sapiens
26 PCYT1A 5130
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PRPH2 is involved
No pathways found





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