Gene description for ACSL6
Gene name acyl-CoA synthetase long-chain family member 6
Gene symbol ACSL6
Other names/aliases ACS2
FACL6
LACS 6
LACS2
LACS5
Species Homo sapiens
 Database cross references - ACSL6
ExoCarta ExoCarta_23305
Entrez Gene 23305
HGNC 16496
MIM 604443
UniProt Q9UKU0  
 ACSL6 identified in exosomes derived from the following tissue/cell type
Urine 21595033    
Urine 21595033    
Urine 21595033    
 Gene ontology annotations for ACSL6
Molecular Function
    enzyme binding GO:0019899 IPI
    ATP binding GO:0005524 IEA
    protein homodimerization activity GO:0042803 IDA
    long-chain fatty acid-CoA ligase activity GO:0004467 NAS
Biological Process
    positive regulation of plasma membrane long-chain fatty acid transport GO:0010747 IEA
    long-chain fatty-acyl-CoA biosynthetic process GO:0035338 TAS
    response to steroid hormone GO:0048545 IEA
    positive regulation of neuron projection development GO:0010976 IEA
    neuroblast proliferation GO:0007405 IEA
    small molecule metabolic process GO:0044281 TAS
    cellular lipid metabolic process GO:0044255 TAS
    acyl-CoA metabolic process GO:0006637 NAS
    response to hypoxia GO:0001666 IEA
    long-chain fatty acid metabolic process GO:0001676 IEA
    response to nutrient GO:0007584 IEA
    neuron development GO:0048666 IEA
    positive regulation of triglyceride biosynthetic process GO:0010867 IEA
    cellular response to insulin stimulus GO:0032869 IEA
    phospholipid biosynthetic process GO:0008654 IEA
    triglyceride biosynthetic process GO:0019432 TAS
    fatty acid transport GO:0015908 IEA
    response to gravity GO:0009629 IEA
Subcellular Localization
    peroxisomal membrane GO:0005778 IEA
    integral component of membrane GO:0016021 IEA
    membrane GO:0016020 IDA
    mitochondrial outer membrane GO:0005741 IEA
    plasma membrane GO:0005886 NAS
    nucleus GO:0005634 IEA
    endoplasmic reticulum membrane GO:0005789 TAS
 Experiment description of studies that identified ACSL6 in exosomes
1
Experiment ID 193
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63|CD9
EV Membrane markers
PHB
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC.
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 194
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC.
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of basement membrane nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 195
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC.
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of early IgA nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ACSL6
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ACSL6 is involved
PathwayEvidenceSource
Synthesis of very long-chain fatty acyl-CoAs TAS Reactome





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