Gene description for SLMAP
Gene name sarcolemma associated protein
Gene symbol SLMAP
Other names/aliases SLAP
Species Homo sapiens
 Database cross references - SLMAP
ExoCarta ExoCarta_7871
Vesiclepedia VP_7871
Entrez Gene 7871
HGNC 16643
MIM 602701
UniProt Q14BN4  
 SLMAP identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for SLMAP
Molecular Function
    protein binding GO:0005515 IPI
    protein-macromolecule adaptor activity GO:0030674 IDA
Biological Process
    muscle contraction GO:0006936 TAS
    negative regulation of hippo signaling GO:0035331 IBA
    negative regulation of hippo signaling GO:0035331 IDA
    protein localization to plasma membrane GO:0072659 IMP
    regulation of membrane depolarization during cardiac muscle cell action potential GO:1900825 IBA
    regulation of membrane depolarization during cardiac muscle cell action potential GO:1900825 IMP
    regulation of sodium ion transmembrane transport GO:1902305 IMP
    regulation of voltage-gated sodium channel activity GO:1905150 IMP
Subcellular Localization
    cytoplasm GO:0005737 IDA
    endoplasmic reticulum membrane GO:0005789 IEA
    smooth endoplasmic reticulum GO:0005790 TAS
    centrosome GO:0005813 IEA
    plasma membrane GO:0005886 TAS
    Z disc GO:0030018 IEA
    M band GO:0031430 IEA
    mitochondrial membrane GO:0031966 IEA
    sarcolemma GO:0042383 IEA
    FAR/SIN/STRIPAK complex GO:0090443 IDA
 Experiment description of studies that identified SLMAP in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SLMAP
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LYPD3 27076
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 CCSER2 54462
Proximity Label-MS Homo sapiens
3 STK25 10494
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 SIKE1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 Strip1  
Affinity Capture-MS Mus musculus
6 RABEP2 79874
Affinity Capture-MS Homo sapiens
7 RPL13A 23521
Cross-Linking-MS (XL-MS) Homo sapiens
8 STRN3 29966
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 TAB1 10454
Proximity Label-MS Homo sapiens
10 CSNK2A1 1457
Affinity Capture-MS Homo sapiens
11 DNAJC25 548645
Proximity Label-MS Homo sapiens
12 PTPN1 5770
Proximity Label-MS Homo sapiens
13 SYVN1 84447
Affinity Capture-MS Homo sapiens
14 STX4 6810
Proximity Label-MS Homo sapiens
15 FAXC  
Affinity Capture-MS Homo sapiens
16 RTN4 57142
Affinity Capture-MS Homo sapiens
17 APEX1 328
Affinity Capture-RNA Homo sapiens
18 RALGAPB 57148
Proximity Label-MS Homo sapiens
19 PDCD10 11235
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 PPP2R1B 5519
Affinity Capture-MS Homo sapiens
21 RDX 5962
Proximity Label-MS Homo sapiens
22 STRN 6801
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 ATXN2L 11273
Affinity Capture-MS Homo sapiens
24 FAM83B  
Proximity Label-MS Homo sapiens
25 COPB2 9276
Affinity Capture-MS Homo sapiens
26 PFDN4 5203
Co-fractionation Homo sapiens
27 SSR1 6745
Proximity Label-MS Homo sapiens
28 DYNLL1 8655
Affinity Capture-MS Homo sapiens
29 STRIP1 85369
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 PFDN6 10471
Co-fractionation Homo sapiens
31 CEP131 22994
Proximity Label-MS Homo sapiens
32 PSMC3 5702
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 PRPH2 5961
Affinity Capture-MS Homo sapiens
34 KIAA1715 80856
Proximity Label-MS Homo sapiens
35 PFN1 5216
Proximity Label-MS Homo sapiens
36 RABGEF1 27342
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 ZNF550  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 EMD 2010
Proximity Label-MS Homo sapiens
39 MOB4 25843
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 COPE 11316
Affinity Capture-MS Homo sapiens
41 CEP192 55125
Proximity Label-MS Homo sapiens
42 RABEP1 9135
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 GOLGA8G  
Affinity Capture-MS Homo sapiens
44 OFD1 8481
Proximity Label-MS Homo sapiens
45 Ppp2ca 19052
Affinity Capture-MS Mus musculus
46 PFDN2 5202
Co-fractionation Homo sapiens
47 PPP2CB 5516
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 SYNC  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 TCTN2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 PPP2CA 5515
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 ACOX2  
Affinity Capture-MS Homo sapiens
52 CATSPER4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 DYNLL2 140735
Affinity Capture-MS Homo sapiens
54 EIF4EBP1  
Proximity Label-MS Homo sapiens
55 SEC62 7095
Proximity Label-MS Homo sapiens
56 SEC61B 10952
Proximity Label-MS Homo sapiens
57 RMDN3 55177
Proximity Label-MS Homo sapiens
58 PTAR1 375743
Synthetic Lethality Homo sapiens
59 KCNA10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 CDS2 8760
Affinity Capture-MS Homo sapiens
61 BCAP31 10134
Proximity Label-MS Homo sapiens
62 STK3 6788
Proximity Label-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
63 PER2  
Affinity Capture-MS Homo sapiens
64 RALGAPA1 253959
Proximity Label-MS Homo sapiens
65 Strn3  
Affinity Capture-MS Mus musculus
66 F2RL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 BTNL9  
Affinity Capture-MS Homo sapiens
68 RAB5A 5868
Proximity Label-MS Homo sapiens
69 PIP 5304
Affinity Capture-MS Homo sapiens
70 SMIM5  
Affinity Capture-MS Homo sapiens
71 TNFRSF1A 7132
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 HSD3B7 80270
Proximity Label-MS Homo sapiens
73 STIM1 6786
Proximity Label-MS Homo sapiens
74 LIN9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 PRPF19 27339
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 PPP2R1A 5518
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
77 ATP2A1 487
Proximity Label-MS Homo sapiens
78 CEP170B  
Proximity Label-MS Homo sapiens
79 RAB9A 9367
Proximity Label-MS Homo sapiens
80 AMOT 154796
Proximity Label-MS Homo sapiens
81 STK4 6789
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Proximity Label-MS Homo sapiens
82 IRF3 3661
Affinity Capture-MS Homo sapiens
83 KIAA1522 57648
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
84 CRNN 49860
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
85 ZRANB1 54764
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
86 RASSF3 283349
Affinity Capture-MS Homo sapiens
87 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
88 STK24 8428
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
89 TACR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 PLP1 5354
Affinity Capture-MS Homo sapiens
91 PRDM14  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
92 STRIP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
93 VAC14 55697
Affinity Capture-MS Homo sapiens
94 FRYL 285527
Proximity Label-MS Homo sapiens
95 STRN4 29888
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
96 HDAC6 10013
Proximity Label-MS Homo sapiens
97 CENPJ 55835
Proximity Label-MS Homo sapiens
98 GFOD1  
Proximity Label-MS Homo sapiens
99 CCDC89  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
100 STK26 51765
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
101 SCN4A  
Affinity Capture-MS Homo sapiens
102 ISCA2 122961
Affinity Capture-MS Homo sapiens
103 PSMA5 5686
Affinity Capture-MS Homo sapiens
104 FGFR1OP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
105 STX3 6809
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
106 KXD1 79036
Affinity Capture-MS Homo sapiens
107 EVA1B 55194
Affinity Capture-MS Homo sapiens
108 DNAJC1 64215
Proximity Label-MS Homo sapiens
109 C1orf210  
Affinity Capture-MS Homo sapiens
110 NHSL2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
111 CNTROB  
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SLMAP is involved
No pathways found





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