Gene description for PTAR1
Gene name protein prenyltransferase alpha subunit repeat containing 1
Gene symbol PTAR1
Other names/aliases -
Species Homo sapiens
 Database cross references - PTAR1
ExoCarta ExoCarta_375743
Vesiclepedia VP_375743
Entrez Gene 375743
HGNC 30449
UniProt Q7Z6K3  
 PTAR1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Endothelial cells 26027894    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for PTAR1
Molecular Function
    Rab geranylgeranyltransferase activity GO:0004663 IBA
Subcellular Localization
    cytoplasm GO:0005737 IBA
    mitochondrion GO:0005739 HTP
 Experiment description of studies that identified PTAR1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 226
MISEV standards
✔
EM
Biophysical techniques
✔
GAPDH|CD9|FLOT1
Enriched markers
✔
LMNA|H2AFX|ATP5A1|TOMM20
Negative markers
✘ Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description "Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting"
Authors "Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar"
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
6
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for PTAR1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RAB18 22931
Synthetic Lethality Homo sapiens
2 FBXO8  
Synthetic Lethality Homo sapiens
3 VPS54  
Synthetic Lethality Homo sapiens
4 UNC50  
Synthetic Lethality Homo sapiens
5 NXT2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 C17orf80 55028
Proximity Label-MS Homo sapiens
7 FASN 2194
Negative Genetic Homo sapiens
8 SEC24A 10802
Synthetic Lethality Homo sapiens
9 VPS53 55275
Synthetic Lethality Homo sapiens
10 VAMP3 9341
Synthetic Lethality Homo sapiens
11 SLC35A2  
Synthetic Lethality Homo sapiens
12 RAB1A 5861
Synthetic Lethality Homo sapiens
Synthetic Lethality Homo sapiens
13 SNAP23 8773
Synthetic Lethality Homo sapiens
14 C10orf76  
Synthetic Lethality Homo sapiens
Synthetic Lethality Homo sapiens
15 VAPA 9218
Affinity Capture-MS Homo sapiens
16 TXNDC15  
Synthetic Lethality Homo sapiens
17 CTDSPL2  
Synthetic Lethality Homo sapiens
18 GOSR1 9527
Synthetic Lethality Homo sapiens
Synthetic Lethality Homo sapiens
19 EXOC2 55770
Synthetic Lethality Homo sapiens
20 TM9SF2 9375
Synthetic Lethality Homo sapiens
21 VPS52 6293
Synthetic Lethality Homo sapiens
22 TAPT1 202018
Synthetic Lethality Homo sapiens
23 SKP1 6500
Affinity Capture-MS Homo sapiens
24 SPTLC1 10558
Synthetic Lethality Homo sapiens
25 PIKFYVE 200576
Synthetic Lethality Homo sapiens
26 CNIH1  
Synthetic Lethality Homo sapiens
27 SECISBP2L  
Synthetic Lethality Homo sapiens
28 COG7 91949
Synthetic Lethality Homo sapiens
29 Snf8 27681
Affinity Capture-MS Mus musculus
30 SPTSSA  
Synthetic Lethality Homo sapiens
31 RIC1 57589
Synthetic Lethality Homo sapiens
32 EXOSC1 51013
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 YIPF5 81555
Affinity Capture-MS Homo sapiens
34 TMEM165 55858
Synthetic Lethality Homo sapiens
Synthetic Lethality Homo sapiens
35 VPS41 27072
Synthetic Lethality Homo sapiens
36 SGMS1  
Synthetic Lethality Homo sapiens
37 CCDC90B  
Proximity Label-MS Homo sapiens
38 USP8 9101
Synthetic Lethality Homo sapiens
39 EXOC4 60412
Synthetic Lethality Homo sapiens
40 RABL3 285282
Synthetic Lethality Homo sapiens
41 PHB2 11331
Proximity Label-MS Homo sapiens
42 COG6 57511
Synthetic Lethality Homo sapiens
43 SEC23IP 11196
Synthetic Lethality Homo sapiens
44 C12orf49  
Negative Genetic Homo sapiens
45 IST1 9798
Synthetic Lethality Homo sapiens
46 TRAPPC11 60684
Synthetic Lethality Homo sapiens
47 TRAPPC12 51112
Synthetic Lethality Homo sapiens
48 RAB26  
Affinity Capture-MS Homo sapiens
49 SGMS2 166929
Synthetic Lethality Homo sapiens
50 ANKRD11 29123
Synthetic Lethality Homo sapiens
51 TRAPPC13 80006
Synthetic Lethality Homo sapiens
52 GOLGA5 9950
Phenotypic Suppression Homo sapiens
53 SLC25A51  
Proximity Label-MS Homo sapiens
54 CMTR2  
Synthetic Lethality Homo sapiens
55 NAA30 122830
Synthetic Lethality Homo sapiens
56 YKT6 10652
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 PI4KB 5298
Synthetic Lethality Homo sapiens
58 COL4A3BP 10087
Synthetic Lethality Homo sapiens
59 TMED2 10959
Synthetic Lethality Homo sapiens
60 COG3 83548
Synthetic Lethality Homo sapiens
61 RNF145  
Synthetic Lethality Homo sapiens
62 ZFAT  
Synthetic Lethality Homo sapiens
63 RABGGTB 5876
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 UBE2D3 7323
Synthetic Lethality Homo sapiens
65 VPS39 23339
Synthetic Lethality Homo sapiens
66 BRD4 23476
Synthetic Lethality Homo sapiens
67 PPP2R2A 5520
Synthetic Lethality Homo sapiens
68 JTB 10899
Synthetic Lethality Homo sapiens
69 TMEM131  
Synthetic Lethality Homo sapiens
70 SLMAP 7871
Synthetic Lethality Homo sapiens
71 SURF1  
Proximity Label-MS Homo sapiens
72 GTF2I 2969
Synthetic Lethality Homo sapiens
73 SPTLC2 9517
Synthetic Lethality Homo sapiens
74 MCUR1 63933
Proximity Label-MS Homo sapiens
75 COG5 10466
Synthetic Lethality Homo sapiens
76 MARCH6  
Synthetic Lethality Homo sapiens
77 SYPL1 6856
Synthetic Lethality Homo sapiens
78 KIAA0922  
Synthetic Lethality Homo sapiens
View the network image/svg+xml
 Pathways in which PTAR1 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here