Gene description for VPS53
Gene name vacuolar protein sorting 53 homolog (S. cerevisiae)
Gene symbol VPS53
Other names/aliases HCCS1
PCH2E
hVps53L
pp13624
Species Homo sapiens
 Database cross references - VPS53
ExoCarta ExoCarta_55275
Entrez Gene 55275
HGNC 25608
MIM 615850
UniProt Q5VIR6  
 VPS53 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for VPS53
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    retrograde transport, endosome to Golgi GO:0042147 IBA
    protein transport GO:0015031 IEA
Subcellular Localization
    perinuclear region of cytoplasm GO:0048471 IDA
    Golgi apparatus GO:0005794 IDA
    GARP complex GO:0000938 IDA
    endosome membrane GO:0010008 IEA
 Experiment description of studies that identified VPS53 in exosomes
1
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for VPS53
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which VPS53 is involved
No pathways found





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