Gene description for RABGAP1L
Gene name RAB GTPase activating protein 1-like
Gene symbol RABGAP1L
Other names/aliases HHL
TBC1D18
Species Homo sapiens
 Database cross references - RABGAP1L
ExoCarta ExoCarta_9910
Vesiclepedia VP_9910
Entrez Gene 9910
HGNC 24663
MIM 609238
UniProt B7ZAP0   Q5R372  
 RABGAP1L identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for RABGAP1L
Molecular Function
    GTPase activator activity GO:0005096 IBA
    GTPase activator activity GO:0005096 IDA
    protein binding GO:0005515 IPI
    small GTPase binding GO:0031267 IBA
    small GTPase binding GO:0031267 IDA
Biological Process
    endocytosis GO:0006897 IEA
    protein transport GO:0015031 IEA
    regulation of protein localization GO:0032880 IBA
    regulation of protein localization GO:0032880 IDA
Subcellular Localization
    nucleus GO:0005634 IDA
    early endosome GO:0005769 IDA
    Golgi apparatus GO:0005794 IDA
 Experiment description of studies that identified RABGAP1L in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for RABGAP1L
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GABARAPL1 23710
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
2 ACOT7 11332
Affinity Capture-MS Homo sapiens
3 KRT37 8688
Affinity Capture-MS Homo sapiens
4 Pxdc1  
Affinity Capture-MS Mus musculus
5 RNASEH2B  
Affinity Capture-MS Homo sapiens
6 RFTN1 23180
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 LAMP3  
Proximity Label-MS Homo sapiens
8 SYCE1  
Affinity Capture-MS Homo sapiens
9 CCDC132 55610
Affinity Capture-MS Homo sapiens
10 DLK2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 GIT2 9815
Affinity Capture-MS Homo sapiens
12 KIF20A 10112
Affinity Capture-MS Homo sapiens
13 LSM4 25804
Affinity Capture-MS Homo sapiens
14 TUFT1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 ARNTL  
Affinity Capture-MS Homo sapiens
16 NUF2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 PXDC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 STRN 6801
Affinity Capture-MS Homo sapiens
19 CORO1A 11151
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 EXOC1 55763
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 LIN7B  
Affinity Capture-MS Homo sapiens
22 PSMD9 5715
Affinity Capture-MS Homo sapiens
23 OIP5  
Affinity Capture-MS Homo sapiens
24 TRO  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 HAUS6  
Affinity Capture-MS Homo sapiens
26 GGA1 26088
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 TACSTD2 4070
Affinity Capture-MS Homo sapiens
28 VPS53 55275
Affinity Capture-MS Homo sapiens
29 RAB35 11021
Proximity Label-MS Homo sapiens
30 KIF14 9928
Affinity Capture-MS Homo sapiens
31 C15orf59  
Affinity Capture-MS Homo sapiens
32 RAB36  
Two-hybrid Homo sapiens
33 PFN1 5216
Proximity Label-MS Homo sapiens
34 RABGEF1 27342
Affinity Capture-MS Homo sapiens
35 CLOCK  
Affinity Capture-MS Homo sapiens
36 C19orf38  
Affinity Capture-MS Homo sapiens
37 VPS51 738
Affinity Capture-MS Homo sapiens
38 RABEP1 9135
Affinity Capture-MS Homo sapiens
39 RAB4A 5867
Proximity Label-MS Homo sapiens
40 CYB5A 1528
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 Rab3gap1  
Affinity Capture-MS Mus musculus
42 LIN7C 55327
Affinity Capture-MS Homo sapiens
43 Espn  
Affinity Capture-MS Mus musculus
44 TRIM11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 CCDC101  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 RFTN2 130132
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 YEATS4  
Affinity Capture-MS Homo sapiens
48 NCKAP5L  
Affinity Capture-MS Homo sapiens
49 VIPR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 TSSC1 7260
Affinity Capture-MS Homo sapiens
51 RAB34 83871
Two-hybrid Homo sapiens
52 GRIPAP1 56850
Affinity Capture-MS Homo sapiens
53 RAB11A 8766
Proximity Label-MS Homo sapiens
54 PHLDB3  
Affinity Capture-MS Homo sapiens
55 Pkm 18746
Affinity Capture-MS Mus musculus
56 RPRD1A  
Affinity Capture-MS Homo sapiens
57 TFPT  
Affinity Capture-MS Homo sapiens
58 RABGAP1 23637
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Affinity Capture-MS Homo sapiens
59 PKN3 29941
Affinity Capture-MS Homo sapiens
60 Cep152  
Affinity Capture-MS Mus musculus
61 NXF1 10482
Affinity Capture-RNA Homo sapiens
62 MLF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 HOXA4  
Affinity Capture-MS Homo sapiens
64 RAB9A 9367
Proximity Label-MS Homo sapiens
65 HOXC4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 PHF21A  
Affinity Capture-MS Homo sapiens
67 Csk 12988
Affinity Capture-MS Mus musculus
68 HMG20A  
Affinity Capture-MS Homo sapiens
69 DZIP3  
Affinity Capture-MS Homo sapiens
70 GYPA  
Affinity Capture-MS Homo sapiens
71 MAX  
Affinity Capture-MS Homo sapiens
72 JUP 3728
Co-fractionation Homo sapiens
73 FBXL6  
Proximity Label-MS Homo sapiens
74 ECSCR  
Affinity Capture-MS Homo sapiens
75 CCHCR1  
Affinity Capture-MS Homo sapiens
76 HOXD13  
Affinity Capture-MS Homo sapiens
77 BFSP1  
Affinity Capture-MS Homo sapiens
78 RPS12 6206
Co-fractionation Homo sapiens
79 THAP11 57215
Affinity Capture-MS Homo sapiens
80 SHMT2 6472
Affinity Capture-RNA Homo sapiens
81 DDX58 23586
Affinity Capture-RNA Homo sapiens
82 CCDC93 54520
Affinity Capture-MS Homo sapiens
83 HMGXB4 10042
Affinity Capture-MS Homo sapiens
84 MAP1LC3A 84557
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
85 KDM1A 23028
Affinity Capture-MS Homo sapiens
86 GOLGA5 9950
Affinity Capture-MS Homo sapiens
87 RAB13 5872
Two-hybrid Homo sapiens
88 CLTA 1211
Proximity Label-MS Homo sapiens
89 RSAD2  
Affinity Capture-MS Homo sapiens
90 PTRF 284119
Affinity Capture-MS Homo sapiens
91 RCOR1  
Affinity Capture-MS Homo sapiens
92 ZNF365  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which RABGAP1L is involved
No pathways found





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