Gene description for CORO1A
Gene name coronin, actin binding protein, 1A
Gene symbol CORO1A
Other names/aliases CLABP
CLIPINA
HCORO1
IMD8
TACO
p57
Species Homo sapiens
 Database cross references - CORO1A
ExoCarta ExoCarta_11151
Entrez Gene 11151
HGNC 2252
MIM 605000
UniProt P31146  
 CORO1A identified in exosomes derived from the following tissue/cell type
B cells 20458337    
B cells 20458337    
B cells 20458337    
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
Prostate cancer cells 25844599    
Thymus 23844026    
 Gene ontology annotations for CORO1A
Molecular Function
    protein homodimerization activity GO:0042803 IDA
    actin filament binding GO:0051015 IMP
    myosin heavy chain binding GO:0032036 IPI
    phosphatidylinositol 3-kinase binding GO:0043548 IDA
    cytoskeletal protein binding GO:0008092 ISS
    actin monomer binding GO:0003785 IMP
    protein C-terminus binding GO:0008022 IPI
    protein binding GO:0005515 IPI
    poly(A) RNA binding GO:0044822 IDA
    actin binding GO:0003779 IPI
Biological Process
    early endosome to recycling endosome transport GO:0061502 IEA
    negative regulation of vesicle fusion GO:0031339 IEA
    innate immune response GO:0045087 NAS
    T cell homeostasis GO:0043029 IEA
    cell-substrate adhesion GO:0031589 IMP
    phagolysosome assembly GO:0001845 IMP
    calcium ion transport GO:0006816 IEA
    regulation of actin cytoskeleton organization GO:0032956 IMP
    regulation of cell shape GO:0008360 IEA
    nerve growth factor signaling pathway GO:0038180 IEA
    negative regulation of neuron apoptotic process GO:0043524 IEA
    immunological synapse formation GO:0001771 IMP
    positive chemotaxis GO:0050918 IDA
    uropod organization GO:0032796 IEA
    positive regulation of T cell proliferation GO:0042102 IEA
    phagocytosis GO:0006909 IMP
    regulation of actin filament polymerization GO:0030833 IEA
    movement of cell or subcellular component GO:0006928 NAS
    positive regulation of cell migration GO:0030335 IEA
    natural killer cell degranulation GO:0043320 IMP
    cellular response to interleukin-4 GO:0071353 IEA
    homeostasis of number of cells within a tissue GO:0048873 IEA
    actin cytoskeleton organization GO:0030036 IMP
    actin filament organization GO:0007015 IEA
    regulation of release of sequestered calcium ion into cytosol GO:0051279 IEA
    negative regulation of actin nucleation GO:0051126 IDA
    leukocyte chemotaxis GO:0030595 IEA
Subcellular Localization
    membrane GO:0016020 IDA
    extracellular exosome GO:0070062 IDA
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IDA
    protein complex GO:0043234 IDA
    actin filament GO:0005884 IDA
    lamellipodium GO:0030027 IDA
    axon GO:0030424 IEA
    cell-cell junction GO:0005911 IEA
    phagocytic vesicle membrane GO:0030670 IEA
    cortical actin cytoskeleton GO:0030864 IDA
    early endosome GO:0005769 IEA
    actin cytoskeleton GO:0015629 IBA
    phagocytic vesicle GO:0045335 IDA
    phagocytic cup GO:0001891 IDA
    plasma membrane GO:0005886 IDA
    immunological synapse GO:0001772 IDA
 Experiment description of studies that identified CORO1A in exosomes
1
Experiment ID 79
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
CD81|MHCII
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 1
Authors Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W.
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
2
Experiment ID 80
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
CD81|MHCII
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis -Sample 2
Authors Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W.
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
3
Experiment ID 81
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
CD81|MHCII
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 3
Authors Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W.
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
4
Experiment ID 231
ISEV standards
EV Biophysical techniques
Alix
EV Cytosolic markers
CD63|CD9
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
5
Experiment ID 232
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
6
Experiment ID 233
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 275
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|RAB5A
EV Cytosolic markers
CD9|CD82|CD63|CD81
EV Membrane markers
AIF
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
8
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CORO1A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DKK1 22943
Affinity Capture-MS Homo sapiens
2 UBE2G2  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CORO1A is involved
No pathways found





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