Gene description for POC1B
Gene name POC1 centriolar protein B
Gene symbol POC1B
Other names/aliases CORD20
PIX1
TUWD12
WDR51B
Species Homo sapiens
 Database cross references - POC1B
ExoCarta ExoCarta_282809
Vesiclepedia VP_282809
Entrez Gene 282809
HGNC 30836
MIM 614784
UniProt Q8TC44  
 POC1B identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for POC1B
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    cell morphogenesis GO:0000902 IEA
    acrosome assembly GO:0001675 IEA
    retina homeostasis GO:0001895 IMP
    centriole replication GO:0007099 IDA
    single fertilization GO:0007338 IEA
    cell population proliferation GO:0008283 IMP
    homeostasis of number of cells GO:0048872 IEA
    cilium assembly GO:0060271 IBA
    cilium assembly GO:0060271 IMP
    sperm flagellum assembly GO:0120316 IEA
Subcellular Localization
    spindle pole GO:0000922 IDA
    cytoplasm GO:0005737 IEA
    centrosome GO:0005813 IDA
    centriole GO:0005814 IBA
    centriole GO:0005814 IDA
    ciliary basal body GO:0036064 IBA
    ciliary basal body GO:0036064 IDA
 Experiment description of studies that identified POC1B in exosomes
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for POC1B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FTL 2512
Affinity Capture-MS Homo sapiens
2 ZNF598 90850
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 FAM175B 23172
Affinity Capture-MS Homo sapiens
4 EXOC7 23265
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 CCT3 7203
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 AKIP1  
Affinity Capture-MS Homo sapiens
7 PIP4K2C 79837
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 CHTOP  
Affinity Capture-MS Homo sapiens
9 TUBG1 7283
Co-localization Homo sapiens
10 HSBP1 3281
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 CCT2 10576
Affinity Capture-MS Homo sapiens
12 C15orf59  
Affinity Capture-MS Homo sapiens
13 TDP1  
Affinity Capture-MS Homo sapiens
14 SARM1 23098
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 SPRR1B 6699
Affinity Capture-MS Homo sapiens
16 MIIP 60672
Affinity Capture-MS Homo sapiens
17 WDR47  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 CUL3 8452
Affinity Capture-MS Homo sapiens
19 TDRD3  
Affinity Capture-MS Homo sapiens
20 SIL1 64374
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 CCT4 10575
Affinity Capture-MS Homo sapiens
22 PELO 53918
Affinity Capture-MS Homo sapiens
23 CUL4B 8450
Affinity Capture-Western Homo sapiens
24 Cep44  
Affinity Capture-MS Mus musculus
25 IKZF1  
Affinity Capture-MS Homo sapiens
26 CEP97 79598
Co-localization Homo sapiens
27 TUBA1A 7846
Co-localization Homo sapiens
28 TPM2 7169
Affinity Capture-MS Homo sapiens
29 EXOC4 60412
Affinity Capture-MS Homo sapiens
30 CEP44  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
31 POC1A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 COG6 57511
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 NELL2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 PFDN2 5202
Affinity Capture-MS Homo sapiens
35 PCNT  
Co-localization Homo sapiens
36 SUV420H2  
Affinity Capture-MS Homo sapiens
37 NUDC 10726
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 FAM161A  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
39 BLOC1S4 55330
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 CEP135  
Proximity Label-MS Homo sapiens
41 CCDC107  
Affinity Capture-MS Homo sapiens
42 POC1B-GALNT4 100528030
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 Poc1b  
Affinity Capture-MS Mus musculus
44 CORO1A 11151
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 TACC1 6867
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 HNRNPU 3192
Affinity Capture-MS Homo sapiens
47 CCDC53 51019
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 FBXO28  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 KDM4A  
Affinity Capture-MS Homo sapiens
50 COG7 91949
Affinity Capture-MS Homo sapiens
51 CUL4A 8451
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which POC1B is involved
No pathways found





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