Gene description for PI4KB
Gene name phosphatidylinositol 4-kinase, catalytic, beta
Gene symbol PI4KB
Other names/aliases NPIK
PI4K-BETA
PI4K92
PI4KBETA
PI4KIIIBETA
PIK4CB
Species Homo sapiens
 Database cross references - PI4KB
ExoCarta ExoCarta_5298
Vesiclepedia VP_5298
Entrez Gene 5298
HGNC 8984
MIM 602758
UniProt Q9UBF8  
 PI4KB identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
Urine 22418980    
Urine 22418980    
 Gene ontology annotations for PI4KB
Molecular Function
    1-phosphatidylinositol 4-kinase activity GO:0004430 TAS
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
Biological Process
    phosphatidylinositol biosynthetic process GO:0006661 TAS
    phosphatidylinositol phosphorylation GO:0046854 IEA
    phospholipid metabolic process GO:0006644 TAS
    phosphatidylinositol-mediated signaling GO:0048015 IEA
    small molecule metabolic process GO:0044281 TAS
    receptor-mediated endocytosis GO:0006898 TAS
    signal transduction GO:0007165 TAS
Subcellular Localization
    endosome GO:0005768 TAS
    perinuclear region of cytoplasm GO:0048471 IEA
    cytosol GO:0005829 TAS
    cytoplasm GO:0005737 TAS
    mitochondrial outer membrane GO:0005741 IEA
    rough endoplasmic reticulum membrane GO:0030867 IEA
    Golgi membrane GO:0000139 TAS
 Experiment description of studies that identified PI4KB in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 196
MISEV standards
✔
EM
EV Biophysical techniques
✔
Alix|TSG101|HSP70|CD9
EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors Raj DA, Fiume I, Capasso G, Pocsfalvi G.
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal high density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 197
MISEV standards
✔
EM
EV Biophysical techniques
✔
Alix|TSG101|HSP70|CD9
EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors Raj DA, Fiume I, Capasso G, Pocsfalvi G.
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal low density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PI4KB
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 YWHAQ 10971
Affinity Capture-MS Homo sapiens
2 SFN 2810
Affinity Capture-MS Homo sapiens
3 YWHAG 7532
Affinity Capture-MS Homo sapiens
4 YWHAB 7529
Affinity Capture-MS Homo sapiens
5 NCS1 23413
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which PI4KB is involved
PathwayEvidenceSource
Synthesis of PIPs at the Golgi membrane TAS Reactome





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