Gene description for DNAJC10
Gene name DnaJ (Hsp40) homolog, subfamily C, member 10
Gene symbol DNAJC10
Other names/aliases ERdj5
JPDI
MTHr
PDIA19
Species Homo sapiens
 Database cross references - DNAJC10
ExoCarta ExoCarta_54431
Entrez Gene 54431
HGNC 24637
MIM 607987
UniProt Q8IXB1  
 DNAJC10 identified in exosomes derived from the following tissue/cell type
Urine 22418980    
Urine 22418980    
 Gene ontology annotations for DNAJC10
Molecular Function
    ATPase activator activity GO:0001671 ISS
    disulfide oxidoreductase activity GO:0015036 ISS
    ATPase binding GO:0051117 IPI
    protein disulfide oxidoreductase activity GO:0015035 ISS
    misfolded protein binding GO:0051787 IDA
    Hsp70 protein binding GO:0030544 IPI
    oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor GO:0016671 ISS
    chaperone binding GO:0051087 IDA
    protein binding GO:0005515 IPI
Biological Process
    oxidation-reduction process GO:0055114 IEA
    cell redox homeostasis GO:0045454 IEA
    ER-associated ubiquitin-dependent protein catabolic process GO:0030433 IMP
    negative regulation of protein phosphorylation GO:0001933 IDA
    positive regulation of ATPase activity GO:0032781 ISS
    intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070059 IDA
    protein folding in endoplasmic reticulum GO:0034975 IDA
    response to endoplasmic reticulum stress GO:0034976 IDA
Subcellular Localization
    endoplasmic reticulum lumen GO:0005788 IDA
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum chaperone complex GO:0034663 IDA
    membrane GO:0016020 IDA
 Experiment description of studies that identified DNAJC10 in exosomes
1
Experiment ID 196
ISEV standards
EM
EV Biophysical techniques
Alix|TSG101|HSP70
EV Cytosolic markers
CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors Raj DA, Fiume I, Capasso G, Pocsfalvi G.
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal high density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 197
ISEV standards
EM
EV Biophysical techniques
Alix|TSG101|HSP70
EV Cytosolic markers
CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors Raj DA, Fiume I, Capasso G, Pocsfalvi G.
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal low density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for DNAJC10
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HSPA5 3309
Invitro Homo sapiens
2 MAGEA11  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which DNAJC10 is involved
No pathways found





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