Gene description for PGAM5
Gene name phosphoglycerate mutase family member 5
Gene symbol PGAM5
Other names/aliases BXLBV68
Species Homo sapiens
 Database cross references - PGAM5
ExoCarta ExoCarta_192111
Entrez Gene 192111
HGNC 28763
MIM 614939
UniProt Q96HS1  
 PGAM5 identified in exosomes derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
 Gene ontology annotations for PGAM5
Molecular Function
    phosphatase activity GO:0016791 IMP
    protein complex binding GO:0032403 IDA
    GTPase activator activity GO:0005096 IMP
    receptor signaling protein serine/threonine phosphatase activity GO:0009400 IDA
Biological Process
    positive regulation of GTPase activity GO:0043547 IMP
    necroptotic process GO:0070266 IMP
    intracellular signal transduction GO:0035556 IDA
    dephosphorylation GO:0016311 IMP
Subcellular Localization
    mitochondrion GO:0005739 IDA
    mitochondrial outer membrane GO:0005741 IEA
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified PGAM5 in exosomes
1
Experiment ID 191
ISEV standards
EV Biophysical techniques
Alix
EV Cytosolic markers
CD81|CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PGAM5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ZBTB16  
Two-hybrid Homo sapiens
2 SETDB1  
Two-hybrid Homo sapiens
3 HSPA1B 3304
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which PGAM5 is involved
No pathways found





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