Gene description for BRD8
Gene name bromodomain containing 8
Gene symbol BRD8
Other names/aliases SMAP
Species Homo sapiens
 Database cross references - BRD8
ExoCarta ExoCarta_10902
Entrez Gene 10902
HGNC 19874
MIM 602848
UniProt Q9H0E9  
 BRD8 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for BRD8
Molecular Function
    thyroid hormone receptor activity GO:0004887 TAS
    protein binding GO:0005515 IPI
    sequence-specific DNA binding transcription factor activity GO:0003700 NAS
Biological Process
    histone H2A acetylation GO:0043968 IDA
    transcription, DNA-templated GO:0006351 IEA
    cell surface receptor signaling pathway GO:0007166 TAS
    regulation of transcription, DNA-templated GO:0006355 NAS
    chromatin organization GO:0006325 TAS
    regulation of transcription from RNA polymerase II promoter GO:0006357 TAS
    signal transduction GO:0007165 TAS
    intracellular receptor signaling pathway GO:0030522 TAS
    histone H4 acetylation GO:0043967 IDA
    regulation of growth GO:0040008 IEA
Subcellular Localization
    NuA4 histone acetyltransferase complex GO:0035267 IDA
    nucleoplasm GO:0005654 TAS
    nucleus GO:0005634 NAS
    Swr1 complex GO:0000812 IDA
    mitochondrion GO:0005739 IDA
 Experiment description of studies that identified BRD8 in exosomes
Experiment ID 235
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for BRD8
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 THRB 7068
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
2 PPARG 5468
Affinity Capture-MS Homo sapiens
3 RXRA  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which BRD8 is involved
HATs acetylate histones TAS Reactome

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