Gene description for BRD8
Gene name bromodomain containing 8
Gene symbol BRD8
Other names/aliases SMAP
SMAP2
p120
Species Homo sapiens
 Database cross references - BRD8
ExoCarta ExoCarta_10902
Vesiclepedia VP_10902
Entrez Gene 10902
HGNC 19874
MIM 602848
UniProt Q9H0E9  
 BRD8 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for BRD8
Molecular Function
    protein binding GO:0005515 IPI
    nuclear receptor coactivator activity GO:0030374 IDA
    nuclear thyroid hormone receptor binding GO:0046966 IPI
Biological Process
    chromatin organization GO:0006325 IEA
    cell surface receptor signaling pathway GO:0007166 TAS
    regulation of apoptotic process GO:0042981 NAS
    positive regulation of DNA-templated transcription GO:0045893 NAS
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    regulation of cell cycle GO:0051726 IMP
    cellular response to thyroid hormone stimulus GO:0097067 IDA
    positive regulation of double-strand break repair via homologous recombination GO:1905168 IDA
    regulation of double-strand break repair GO:2000779 NAS
Subcellular Localization
    nucleosome GO:0000786 IDA
    Swr1 complex GO:0000812 IDA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    mitochondrion GO:0005739 IDA
    NuA4 histone acetyltransferase complex GO:0035267 IBA
    NuA4 histone acetyltransferase complex GO:0035267 IDA
 Experiment description of studies that identified BRD8 in exosomes
1
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for BRD8
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MCRS1  
Two-hybrid Homo sapiens
2 Chek2  
Affinity Capture-MS Mus musculus
3 FOXR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 HIST1H2BE 8344
Affinity Capture-MS Homo sapiens
5 MBTD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 RGAG1  
Affinity Capture-MS Homo sapiens
7 Ruvbl1 56505
Affinity Capture-MS Mus musculus
8 ADCK3  
Affinity Capture-MS Homo sapiens
9 SACM1L 22908
Affinity Capture-MS Homo sapiens
10 TRRAP 8295
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 THRB 7068
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
12 PKP2 5318
Affinity Capture-MS Homo sapiens
13 HIST1H2BG 8339
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 ACTC1 70
Affinity Capture-MS Homo sapiens
15 MRFAP1  
Affinity Capture-MS Homo sapiens
16 ADGRL2 23266
Affinity Capture-MS Homo sapiens
17 HIST3H2BB 128312
Affinity Capture-MS Homo sapiens
18 SAMD1  
Affinity Capture-MS Homo sapiens
19 UNC45B  
Affinity Capture-MS Homo sapiens
20 TAF1  
Affinity Capture-MS Homo sapiens
21 ELF4 2000
Proximity Label-MS Homo sapiens
22 APOD 347
Affinity Capture-MS Homo sapiens
23 JAZF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 APEX1 328
Affinity Capture-RNA Homo sapiens
25 DIMT1 27292
Affinity Capture-MS Homo sapiens
26 MRFAP1L1  
Affinity Capture-MS Homo sapiens
27 RUVBL1 8607
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 MEAF6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 C11orf30  
Affinity Capture-MS Homo sapiens
30 VPS72  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 ACTL7A  
Affinity Capture-MS Homo sapiens
32 KLF8  
Proximity Label-MS Homo sapiens
33 DDX24 57062
Affinity Capture-MS Homo sapiens
34 DGKE  
Affinity Capture-MS Homo sapiens
35 ING3  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 TIMM23 100287932
Affinity Capture-MS Homo sapiens
37 KLF6  
Proximity Label-MS Homo sapiens
38 FOXR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 CREB1  
Affinity Capture-MS Homo sapiens
40 FBL 2091
Affinity Capture-MS Homo sapiens
41 KLF15  
Proximity Label-MS Homo sapiens
42 PLAC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 AGTR1  
Two-hybrid Homo sapiens
44 ACOT8 10005
Affinity Capture-MS Homo sapiens
45 SLC25A19  
Affinity Capture-MS Homo sapiens
46 BRD4 23476
Affinity Capture-MS Homo sapiens
47 BRPF3  
Affinity Capture-MS Homo sapiens
48 PALB2  
Affinity Capture-MS Homo sapiens
49 FSD2 123722
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
50 ZNHIT6 54680
Affinity Capture-MS Homo sapiens
51 KIF14 9928
Affinity Capture-MS Homo sapiens
52 H2AFZ 3015
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 S100A2 6273
Affinity Capture-MS Homo sapiens
54 IPO11 51194
Affinity Capture-MS Homo sapiens
55 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
56 IRAK1  
Affinity Capture-MS Homo sapiens
57 PGAM5 192111
Affinity Capture-MS Homo sapiens
58 TMEM165 55858
Affinity Capture-MS Homo sapiens
59 CMC1  
Affinity Capture-MS Homo sapiens
60 SP110  
Affinity Capture-MS Homo sapiens
61 ACTL6A 86
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
62 CHEK1  
Affinity Capture-MS Homo sapiens
63 ACTB 60
Affinity Capture-MS Homo sapiens
64 PML 5371
Affinity Capture-MS Homo sapiens
65 PHF12  
Affinity Capture-MS Homo sapiens
66 SDF4 51150
Affinity Capture-MS Homo sapiens
67 RHOT2 89941
Affinity Capture-MS Homo sapiens
68 MYCL  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 KDM5A  
Affinity Capture-MS Homo sapiens
70 GNL3L 54552
Affinity Capture-MS Homo sapiens
71 SQRDL 58472
Affinity Capture-MS Homo sapiens
72 YEATS4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 SGPL1 8879
Affinity Capture-MS Homo sapiens
74 S100P 6286
Affinity Capture-MS Homo sapiens
75 MAP7 9053
Affinity Capture-MS Homo sapiens
76 TMX3 54495
Affinity Capture-MS Homo sapiens
77 BAG2 9532
Affinity Capture-MS Homo sapiens
78 ELK3  
Proximity Label-MS Homo sapiens
79 GCDH 2639
Affinity Capture-MS Homo sapiens
80 MIS18A  
Two-hybrid Homo sapiens
81 YY1 7528
Proximity Label-MS Homo sapiens
82 MRGBP  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 EP400  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
84 MORF4L1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
85 TP73  
Affinity Capture-Western Homo sapiens
86 SIN3B  
Affinity Capture-MS Homo sapiens
87 HNF4A  
Proximity Label-MS Homo sapiens
88 DMAP1 55929
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
89 MAP7D1 55700
Affinity Capture-MS Homo sapiens
90 CUL9  
Affinity Capture-MS Homo sapiens
91 RAPGEF2 9693
Affinity Capture-MS Homo sapiens
92 MYC  
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
93 HIST1H2BA 255626
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
94 ING5  
Affinity Capture-MS Homo sapiens
95 TP63  
Affinity Capture-Western Homo sapiens
96 KAT5  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
97 SCO1  
Affinity Capture-MS Homo sapiens
98 RCN2 5955
Affinity Capture-MS Homo sapiens
99 HAX1  
Affinity Capture-MS Homo sapiens
100 GNL3 26354
Affinity Capture-MS Homo sapiens
101 GATAD1  
Affinity Capture-MS Homo sapiens
102 STUB1 10273
Affinity Capture-MS Homo sapiens
103 EP400NL  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
104 MTHFD2 10797
Affinity Capture-MS Homo sapiens
105 Ruvbl2 20174
Affinity Capture-MS Mus musculus
106 MAX  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
107 TIMM17B  
Affinity Capture-MS Homo sapiens
108 CHTOP  
Affinity Capture-MS Homo sapiens
109 TP53 7157
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
110 RUVBL2 10856
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
111 PIN1 5300
Two-hybrid Homo sapiens
112 SOS1 6654
Affinity Capture-MS Homo sapiens
113 MORF4L2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
114 EPC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
115 TIMM21  
Affinity Capture-MS Homo sapiens
116 DHX40  
Proximity Label-MS Homo sapiens
117 RXRA 6256
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
118 LDLR 3949
Positive Genetic Homo sapiens
119 ELF2  
Proximity Label-MS Homo sapiens
120 AR 367
Proximity Label-MS Homo sapiens
121 CKAP4 10970
Affinity Capture-MS Homo sapiens
122 TFAM 7019
Affinity Capture-MS Homo sapiens
123 CSGALNACT1 55790
Affinity Capture-MS Homo sapiens
124 KDM5C  
Affinity Capture-MS Homo sapiens
125 IYD  
Affinity Capture-MS Homo sapiens
126 CDC5L 988
Affinity Capture-MS Homo sapiens
127 EPC2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which BRD8 is involved
PathwayEvidenceSource
Chromatin modifying enzymes IEA Reactome
Chromatin organization IEA Reactome
HATs acetylate histones IEA Reactome





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