Gene description for IPO11
Gene name importin 11
Gene symbol IPO11
Other names/aliases RanBP11
Species Homo sapiens
 Database cross references - IPO11
ExoCarta ExoCarta_51194
Vesiclepedia VP_51194
Entrez Gene 51194
HGNC 20628
MIM 610889
UniProt Q9UI26  
 IPO11 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Chondrocytes 35931686    
Chondrocytes 35931686    
Mesenchymal stem cells 36408942    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Squamous carcinoma cells 20124223    
 Gene ontology annotations for IPO11
Molecular Function
    protein binding GO:0005515 IPI
    small GTPase binding GO:0031267 IEA
    nuclear import signal receptor activity GO:0061608 IEA
Biological Process
    protein import into nucleus GO:0006606 IBA
    ribosomal protein import into nucleus GO:0006610 IEA
Subcellular Localization
    nuclear envelope GO:0005635 IBA
    nucleoplasm GO:0005654 IDA
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IDA
 Experiment description of studies that identified IPO11 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 497
MISEV standards
Biophysical techniques
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 498
MISEV standards
EM
Biophysical techniques
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
7
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
8
Experiment ID 211
MISEV standards
EM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
cytochrome c|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
9
Experiment ID 212
MISEV standards
CEM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
Cytochrome C|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
10
Experiment ID 191
MISEV standards
Biophysical techniques
Alix|CD81|CD9
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors "Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK."
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for IPO11
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TACR3  
Affinity Capture-MS Homo sapiens
2 UBE2H 7328
Affinity Capture-MS Homo sapiens
3 PLCD4  
Two-hybrid Homo sapiens
4 HNRNPH1 3187
Co-fractionation Homo sapiens
5 TPD52L2 7165
Co-fractionation Homo sapiens
6 LPAR6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 TMEM206 55248
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 UBE3A 7337
Co-fractionation Homo sapiens
9 TMEM9B 56674
Affinity Capture-MS Homo sapiens
10 EDNRB 1910
Affinity Capture-MS Homo sapiens
11 AAR2 25980
Affinity Capture-MS Homo sapiens
12 FPR1  
Affinity Capture-MS Homo sapiens
13 C1orf94  
Two-hybrid Homo sapiens
14 FFAR1  
Affinity Capture-MS Homo sapiens
15 PNKD  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 C9orf78 51759
Affinity Capture-MS Homo sapiens
17 VIPR2  
Affinity Capture-MS Homo sapiens
18 C11orf87  
Affinity Capture-MS Homo sapiens
19 UBE2E2  
Reconstituted Complex Homo sapiens
20 RPRM  
Affinity Capture-MS Homo sapiens
21 OPRM1 4988
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 PRDX2 7001
Co-fractionation Homo sapiens
23 LPP 4026
Co-fractionation Homo sapiens
24 C20orf24  
Affinity Capture-MS Homo sapiens
25 TACSTD2 4070
Affinity Capture-MS Homo sapiens
26 ITFG3 83986
Affinity Capture-MS Homo sapiens
27 F2RL1  
Affinity Capture-MS Homo sapiens
28 IL13RA2 3598
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 HNRNPD 3184
Co-fractionation Homo sapiens
30 GPR17 2840
Affinity Capture-MS Homo sapiens
31 NUP155 9631
Proximity Label-MS Homo sapiens
32 AARS 16
Co-fractionation Homo sapiens
33 BSG 682
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 XPO1 7514
Co-fractionation Homo sapiens
35 UBE2E3 10477
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
36 CD70 970
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 PKM 5315
Co-fractionation Homo sapiens
38 GCGR  
Affinity Capture-MS Homo sapiens
39 AGFG1 3267
Co-fractionation Homo sapiens
40 STOM 2040
Affinity Capture-MS Homo sapiens
41 P2RY8  
Affinity Capture-MS Homo sapiens
42 COMTD1 118881
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 RAN 5901
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
44 DDX5 1655
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 NTRK1 4914
Affinity Capture-MS Homo sapiens
46 GPR182  
Affinity Capture-MS Homo sapiens
47 TPRKB 51002
Co-fractionation Homo sapiens
48 ARL13B 200894
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 CEBPA  
Protein-peptide Homo sapiens
50 SLC2A9  
Affinity Capture-MS Homo sapiens
51 METTL1 4234
Co-fractionation Homo sapiens
52 TTLL12 23170
Co-fractionation Homo sapiens
53 MLNR  
Affinity Capture-MS Homo sapiens
54 EIF4A2 1974
Two-hybrid Homo sapiens
55 UPK2 7379
Affinity Capture-MS Homo sapiens
56 CD40 958
Affinity Capture-MS Homo sapiens
57 SLC15A1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 CYB5B 80777
Affinity Capture-MS Homo sapiens
59 APLNR  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 MOB1B 92597
Proximity Label-MS Homo sapiens
61 SIGLECL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 BTNL9  
Affinity Capture-MS Homo sapiens
63 ARPC1B 10095
Co-fractionation Homo sapiens
64 FZD10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 NPTN 27020
Affinity Capture-MS Homo sapiens
66 PTH2R  
Affinity Capture-MS Homo sapiens
67 BRD8 10902
Affinity Capture-MS Homo sapiens
68 CUL3 8452
Affinity Capture-MS Homo sapiens
69 UBE2E1  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
70 FBXO6 26270
Affinity Capture-MS Homo sapiens
71 DHTKD1 55526
Affinity Capture-MS Homo sapiens
72 NXF1 10482
Reconstituted Complex Homo sapiens
Affinity Capture-RNA Homo sapiens
Reconstituted Complex Homo sapiens
73 C3orf18  
Affinity Capture-MS Homo sapiens
74 GPR45  
Affinity Capture-MS Homo sapiens
75 EGFR 1956
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Negative Genetic Homo sapiens
76 RPL12 6136
Two-hybrid Homo sapiens
77 PLIN3 10226
Co-fractionation Homo sapiens
78 UNC45B  
Affinity Capture-MS Homo sapiens
79 SCN2B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 VIPR1  
Affinity Capture-MS Homo sapiens
81 TNFSF13B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 GPR84  
Affinity Capture-MS Homo sapiens
83 BRD3 8019
Affinity Capture-MS Homo sapiens
84 SH3GL2  
Co-fractionation Homo sapiens
85 P2RY12 64805
Affinity Capture-MS Homo sapiens
86 AVPR2  
Affinity Capture-MS Homo sapiens
87 MOB1A 55233
Proximity Label-MS Homo sapiens
88 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
89 MUL1  
Affinity Capture-MS Homo sapiens
90 TRAF2 7186
Two-hybrid Homo sapiens
91 sbr  
Reconstituted Complex Drosophila melanogaster
92 OPALIN  
Affinity Capture-MS Homo sapiens
93 MFSD4  
Affinity Capture-MS Homo sapiens
94 CALU 813
Co-fractionation Homo sapiens
95 KEAP1 9817
Reconstituted Complex Homo sapiens
96 DR1  
Co-fractionation Homo sapiens
97 CHRM4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
98 EFNB1 1947
Affinity Capture-MS Homo sapiens
99 EIF4A3 9775
Co-fractionation Homo sapiens
100 PTGER3  
Affinity Capture-MS Homo sapiens
101 PDLIM5 10611
Co-fractionation Homo sapiens
102 HTR2C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
103 SPN 6693
Affinity Capture-MS Homo sapiens
104 ADORA3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
105 HSF1  
Co-fractionation Homo sapiens
106 SERBP1 26135
Affinity Capture-MS Homo sapiens
107 KRAS 3845
Synthetic Lethality Homo sapiens
Negative Genetic Homo sapiens
108 SRP9 6726
Co-fractionation Homo sapiens
109 CCR6  
Affinity Capture-MS Homo sapiens
110 MEN1 4221
Affinity Capture-MS Homo sapiens
111 CACYBP 27101
Co-fractionation Homo sapiens
112 FPR2  
Affinity Capture-MS Homo sapiens
113 RANGAP1 5905
Co-fractionation Homo sapiens
114 S1PR4  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which IPO11 is involved
No pathways found





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