Gene description for EDNRB
Gene name	endothelin receptor type B
Gene symbol	EDNRB
Other names/aliases	ABCDS ET-B ET-BR ETB ETBR ETRB HSCR HSCR2 WS4A
Species	Homo sapiens
Database cross references - EDNRB
ExoCarta	ExoCarta_1910
Vesiclepedia	VP_1910
Entrez Gene	1910
HGNC	3180
MIM	131244
UniProt	P24530
EDNRB identified in exosomes derived from the following tissue/cell type
Melanoma cells	25950383
Melanoma cells	25950383

Gene ontology annotations for EDNRB

Molecular Function     endothelin receptor activity GO:0004962 IBA     endothelin receptor activity GO:0004962 IDA     endothelin receptor activity GO:0004962 IMP     protein binding GO:0005515 IPI     peptide hormone binding GO:0017046 IPI     type 1 angiotensin receptor binding GO:0031702 IEA Biological Process     negative regulation of transcription by RNA polymerase II GO:0000122 IMP     negative regulation of transcription by RNA polymerase II GO:0000122 ISS     neural crest cell migration GO:0001755 IEA     renin secretion into blood stream GO:0002001 IEA     regulation of heart rate GO:0002027 IEA     regulation of pH GO:0006885 IEA     cell surface receptor signaling pathway GO:0007166 TAS     negative regulation of adenylate cyclase activity GO:0007194 TAS     phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200 IEA     positive regulation of cytosolic calcium ion concentration GO:0007204 IEA     nervous system development GO:0007399 TAS     peripheral nervous system development GO:0007422 IEA     posterior midgut development GO:0007497 IEA     positive regulation of cell population proliferation GO:0008284 IEA     gene expression GO:0010467 IEA     negative regulation of neuron maturation GO:0014043 ISS     response to organic cyclic compound GO:0014070 IEA     vein smooth muscle contraction GO:0014826 IMP     calcium-mediated signaling GO:0019722 IMP     cGMP-mediated signaling GO:0019934 IEA     heparin metabolic process GO:0030202 IEA     melanocyte differentiation GO:0030318 IEA     regulation of fever generation GO:0031620 IEA     aldosterone metabolic process GO:0032341 IEA     enteric smooth muscle cell differentiation GO:0035645 ISS     positive regulation of urine volume GO:0035810 IEA     renal sodium excretion GO:0035812 IEA     epithelial fluid transport GO:0042045 IEA     vasoconstriction GO:0042310 IBA     vasoconstriction GO:0042310 IMP     vasodilation GO:0042311 IEA     negative regulation of apoptotic process GO:0043066 IEA     positive regulation of canonical NF-kappaB signal transduction GO:0043123 IEA     developmental pigmentation GO:0048066 IBA     macrophage chemotaxis GO:0048246 IMP     response to pain GO:0048265 IEA     enteric nervous system development GO:0048484 ISS     regulation of epithelial cell proliferation GO:0050678 IEA     negative regulation of protein metabolic process GO:0051248 IMP     canonical Wnt signaling pathway GO:0060070 IEA     positive regulation of penile erection GO:0060406 IEA     establishment of endothelial barrier GO:0061028 IEA     renal sodium ion absorption GO:0070294 IEA     calcium ion transmembrane transport GO:0070588 IEA     cellular response to lipopolysaccharide GO:0071222 IEA     protein transmembrane transport GO:0071806 IEA     podocyte differentiation GO:0072112 IEA     endothelin receptor signaling pathway GO:0086100 IBA     endothelin receptor signaling pathway GO:0086100 IDA     endothelin receptor signaling pathway GO:0086100 IMP     renal albumin absorption GO:0097018 IEA     neuroblast migration GO:0097402 IEA     chordate pharynx development GO:0160093 IEA     response to sodium phosphate GO:1904383 IEA     response to endothelin GO:1990839 IEA Subcellular Localization     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 TAS     nuclear membrane GO:0031965 IEA