Gene description for PXK
Gene name PX domain containing serine/threonine kinase
Gene symbol PXK
Other names/aliases MONaKA
Species Homo sapiens
 Database cross references - PXK
ExoCarta ExoCarta_54899
Vesiclepedia VP_54899
Entrez Gene 54899
HGNC 23326
MIM 611450
UniProt Q7Z7A4  
 PXK identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for PXK
Molecular Function
    nucleotide binding GO:0000166 NAS
    actin binding GO:0003779 IEA
    protein kinase activity GO:0004672 NAS
    protein binding GO:0005515 ISS
    ATP binding GO:0005524 NAS
    phosphatidylinositol binding GO:0035091 IEA
    phosphatidylinositol binding GO:0035091 NAS
Biological Process
    protein phosphorylation GO:0006468 NAS
    inflammatory response GO:0006954 IMP
    negative regulation of ATP-dependent activity GO:0032780 ISS
    negative regulation of monoatomic ion transport GO:0043271 ISS
    modulation of chemical synaptic transmission GO:0050804 IBA
    modulation of chemical synaptic transmission GO:0050804 ISS
Subcellular Localization
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    cytoplasm GO:0005737 ISS
    cytosol GO:0005829 IDA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 ISS
    protein-containing complex GO:0032991 IEA
    centriolar satellite GO:0034451 IDA
 Experiment description of studies that identified PXK in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for PXK
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FTL 2512
Affinity Capture-MS Homo sapiens
2 HBB 3043
Affinity Capture-MS Homo sapiens
3 GPRC5C 55890
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 PAF1 54623
Affinity Capture-MS Homo sapiens
5 CCKBR  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 TFRC 7037
Co-localization Homo sapiens
7 HNRNPA0 10949
Affinity Capture-MS Homo sapiens
8 TMC6 11322
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 TP53 7157
Affinity Capture-MS Homo sapiens
10 KIAA0196 9897
Affinity Capture-MS Homo sapiens
11 EEA1 8411
Co-localization Homo sapiens
12 USP48  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 HBA2 3040
Affinity Capture-MS Homo sapiens
14 PACSIN2 11252
Affinity Capture-MS Homo sapiens
15 ACTBL2 345651
Affinity Capture-Western Homo sapiens
16 LAMP2 3920
Co-localization Homo sapiens
17 EDNRB 1910
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 SUPT4H1  
Affinity Capture-MS Homo sapiens
19 ANKRD28 23243
Affinity Capture-MS Homo sapiens
20 ANKRD44 91526
Affinity Capture-MS Homo sapiens
21 ALYREF 10189
Affinity Capture-MS Homo sapiens
22 PHKB 5257
Affinity Capture-MS Homo sapiens
23 YBX3 8531
Affinity Capture-MS Homo sapiens
24 DIEXF  
Affinity Capture-MS Homo sapiens
25 ACTB 60
Affinity Capture-MS Homo sapiens
26 PIK3R1 5295
Affinity Capture-Western Homo sapiens
27 FBL 2091
Affinity Capture-MS Homo sapiens
28 CTR9 9646
Affinity Capture-MS Homo sapiens
29 CLEC14A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 TUBB1 81027
Affinity Capture-MS Homo sapiens
31 ACTG1 71
Affinity Capture-MS Homo sapiens
32 DDX55  
Affinity Capture-MS Homo sapiens
33 LEO1 123169
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PXK is involved
No pathways found





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