Gene description for ERAP2
Gene name endoplasmic reticulum aminopeptidase 2
Gene symbol ERAP2
Other names/aliases L-RAP
LRAP
Species Homo sapiens
 Database cross references - ERAP2
ExoCarta ExoCarta_64167
Vesiclepedia VP_64167
Entrez Gene 64167
HGNC 29499
MIM 609497
UniProt Q6P179  
 ERAP2 identified in exosomes derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for ERAP2
Molecular Function
    zinc ion binding GO:0008270 TAS
    metallopeptidase activity GO:0008237 IDA
    aminopeptidase activity GO:0004177 IDA
Biological Process
    antigen processing and presentation of peptide antigen via MHC class I GO:0002474 TAS
    regulation of blood pressure GO:0008217 TAS
    proteolysis GO:0006508 IEA
    antigen processing and presentation of endogenous peptide antigen via MHC class I GO:0019885 TAS
Subcellular Localization
    integral component of membrane GO:0016021 IEA
    endoplasmic reticulum lumen GO:0005788 TAS
    endoplasmic reticulum membrane GO:0005789 IEA
 Experiment description of studies that identified ERAP2 in exosomes
1
Experiment ID 834
MISEV standards
✔
EM
EV Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for ERAP2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ERAP2 is involved
PathwayEvidenceSource
Antigen Presentation: Folding, assembly and peptide loading of class I MHC TAS Reactome





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