Gene description for LTBP3
Gene name latent transforming growth factor beta binding protein 3
Gene symbol LTBP3
Other names/aliases LTBP-3
LTBP2
STHAG6
pp6425
Species Homo sapiens
 Database cross references - LTBP3
ExoCarta ExoCarta_4054
Entrez Gene 4054
HGNC 6716
MIM 602090
UniProt Q9NS15  
 LTBP3 identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25857301    
Saliva 19199708    
 Gene ontology annotations for LTBP3
Molecular Function
    calcium ion binding GO:0005509 IEA
    transforming growth factor beta binding GO:0050431 IPI
Biological Process
    transforming growth factor beta receptor signaling pathway GO:0007179 IEA
    positive regulation of mesenchymal stem cell proliferation GO:1902462 IMP
    negative regulation of chondrocyte differentiation GO:0032331 IEA
    bone morphogenesis GO:0060349 IEA
    transforming growth factor beta activation GO:0036363 IMP
    positive regulation of bone resorption GO:0045780 IEA
    lung saccule development GO:0060430 IEA
    positive regulation of mesenchymal stem cell differentiation GO:2000741 IMP
    bone remodeling GO:0046849 IEA
    extracellular matrix organization GO:0030198 TAS
    negative regulation of bone mineralization GO:0030502 IEA
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular exosome GO:0070062 IDA
    extracellular matrix GO:0031012 IDA
 Experiment description of studies that identified LTBP3 in exosomes
1
Experiment ID 250
ISEV standards
✔
EM
EV Biophysical techniques
✔
GAPDH|TSG101
EV Cytosolic markers
✔
CD63|CD81
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25857301    
Organism Homo sapiens
Experiment description Large oncosomes contain distinct protein cargo and represent a separate functional class of tumor-derived extracellular vesicles.
Authors Minciacchi VR, You S, Spinelli C, Morley S, Zandian M, Aspuria PJ, Cavallini L, Ciardiello C, Reis Sobreiro M, Morello M, Kharmate G, Jang SC, Kim DK, Hosseini-Beheshti E, Tomlinson Guns E, Gleave M, Gho YS, Mathivanan S, Yang W, Freeman MR, Di Vizio D
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - expressing DIAPH3 hRNA
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 66
ISEV standards
✔
IEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
CD63|CD81
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for LTBP3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TGFB3  
Invivo Homo sapiens
2 TGFB2 7042
Invivo Homo sapiens
3 ITGB5 3693
Invivo Homo sapiens
Invitro Homo sapiens
4 TGFB1 7040
Invivo Homo sapiens
View the network image/svg+xml
 Pathways in which LTBP3 is involved
PathwayEvidenceSource
Molecules associated with elastic fibres TAS Reactome





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