Gene description for SEP15
Gene name 15 kDa selenoprotein
Gene symbol SEP15
Other names/aliases -
Species Homo sapiens
 Database cross references - SEP15
ExoCarta ExoCarta_9403
Vesiclepedia VP_9403
Entrez Gene 9403
MIM 606254
UniProt O60613  
 SEP15 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for SEP15
Molecular Function
    protein binding GO:0005515 IPI
    thioredoxin peroxidase activity GO:0008379 IEA
    selenium binding GO:0008430 IEA
    oxidoreductase activity GO:0016491 IBA
Biological Process
    sperm DNA condensation GO:0035092 IEA
    'de novo' post-translational protein folding GO:0051084 TAS
    cellular oxidant detoxification GO:0098869 IEA
Subcellular Localization
    endoplasmic reticulum lumen GO:0005788 IBA
    endoplasmic reticulum lumen GO:0005788 IDA
 Experiment description of studies that identified SEP15 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SEP15
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 SERPINA1 5265
Affinity Capture-MS Homo sapiens
3 METTL23  
Affinity Capture-MS Homo sapiens
4 HBB 3043
Affinity Capture-MS Homo sapiens
5 HSPA5 3309
Proximity Label-MS Homo sapiens
6 ANKFY1 51479
Co-fractionation Homo sapiens
7 NUP205 23165
Co-fractionation Homo sapiens
8 SERPINA12  
Affinity Capture-MS Homo sapiens
9 SMNDC1  
Co-fractionation Homo sapiens
10 CANX 821
Affinity Capture-MS Homo sapiens
11 CALR3  
Proximity Label-MS Homo sapiens
12 PDIA4 9601
Proximity Label-MS Homo sapiens
13 IL25  
Affinity Capture-MS Homo sapiens
14 SDR9C7  
Affinity Capture-MS Homo sapiens
15 BAMBI  
Two-hybrid Homo sapiens
16 TTR 7276
Affinity Capture-MS Homo sapiens
17 CUL3 8452
Affinity Capture-MS Homo sapiens
18 PLD4  
Affinity Capture-MS Homo sapiens
19 PLBD1 79887
Affinity Capture-MS Homo sapiens
20 SERPINB2 5055
Affinity Capture-MS Homo sapiens
21 EIF2S2 8894
Co-fractionation Homo sapiens
22 LGALS3BP 3959
Affinity Capture-MS Homo sapiens
23 ARG1 383
Affinity Capture-MS Homo sapiens
24 E2F4  
Affinity Capture-MS Homo sapiens
25 DCUN1D1 54165
Affinity Capture-MS Homo sapiens
26 ACP5  
Affinity Capture-MS Homo sapiens
27 SERPINB8 5271
Affinity Capture-MS Homo sapiens
28 DNAJB9 4189
Proximity Label-MS Homo sapiens
29 DNAJA1 3301
Affinity Capture-MS Homo sapiens
30 DNAJC10 54431
Proximity Label-MS Homo sapiens
31 XRCC6 2547
Two-hybrid Homo sapiens
32 SERPINB7 8710
Affinity Capture-MS Homo sapiens
33 ANKRD46 157567
Affinity Capture-MS Homo sapiens
34 AGTR1  
Two-hybrid Homo sapiens
35 PTPRO 5800
Affinity Capture-MS Homo sapiens
36 SEC61B 10952
Affinity Capture-MS Homo sapiens
37 CPA4 51200
Affinity Capture-MS Homo sapiens
38 CHMP4A 29082
Co-fractionation Homo sapiens
View the network image/svg+xml
 Pathways in which SEP15 is involved
No pathways found





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