Gene description for ARG1
Gene name arginase 1
Gene symbol ARG1
Other names/aliases -
Species Homo sapiens
 Database cross references - ARG1
ExoCarta ExoCarta_383
Vesiclepedia VP_383
Entrez Gene 383
HGNC 663
MIM 608313
UniProt P05089  
 ARG1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Chondrocytes 35931686    
Chondrocytes 35931686    
Mesenchymal stem cells 36408942    
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
 Gene ontology annotations for ARG1
Molecular Function
    arginase activity GO:0004053 IBA
    protein binding GO:0005515 IPI
    manganese ion binding GO:0030145 IBA
Biological Process
    urea cycle GO:0000050 IEA
    adaptive immune response GO:0002250 IEA
    arginine catabolic process GO:0006527 TAS
    response to nematode GO:0009624 IEA
    arginine catabolic process to ornithine GO:0019547 IBA
    negative regulation of T cell proliferation GO:0042130 IDA
    defense response to protozoan GO:0042832 IEA
    innate immune response GO:0045087 IEA
    negative regulation of activated T cell proliferation GO:0046007 IEA
    negative regulation of type II interferon-mediated signaling pathway GO:0060336 IMP
    positive regulation of neutrophil mediated killing of fungus GO:0070965 IMP
    negative regulation of T-helper 2 cell cytokine production GO:2000552 IEA
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 IDA
    nucleus GO:0005634 HDA
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 IBA
    cytosol GO:0005829 TAS
    azurophil granule lumen GO:0035578 TAS
    specific granule lumen GO:0035580 TAS
 Experiment description of studies that identified ARG1 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 494
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD151|CD63|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Osteoarthritic cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 496
MISEV standards
Biophysical techniques
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
Enriched markers
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Healthy cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
7
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
8
Experiment ID 231
MISEV standards
Biophysical techniques
Alix|CD63|CD9
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
9
Experiment ID 232
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
10
Experiment ID 233
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ARG1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 SEP15 9403
Affinity Capture-MS Homo sapiens
3 CABS1  
Affinity Capture-MS Homo sapiens
4 RPA2 6118
Affinity Capture-MS Homo sapiens
5 EBF2  
Affinity Capture-MS Homo sapiens
6 ZIC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 KDM4A  
Affinity Capture-MS Homo sapiens
8 AZGP1 563
Affinity Capture-MS Homo sapiens
9 GSK3A 2931
Affinity Capture-MS Homo sapiens
10 B3GNT2 10678
Affinity Capture-MS Homo sapiens
11 MCM2 4171
Affinity Capture-MS Homo sapiens
12 NUDT3 11165
Affinity Capture-MS Homo sapiens
13 KPRP 448834
Affinity Capture-MS Homo sapiens
14 UCHL5 51377
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
15 MECP2 4204
Affinity Capture-MS Homo sapiens
16 USP53 54532
Affinity Capture-MS Homo sapiens
17 GSK3B 2932
Affinity Capture-MS Homo sapiens
18 ESR1  
Affinity Capture-MS Homo sapiens
19 FCF1  
Affinity Capture-MS Homo sapiens
20 DSG1 1828
Affinity Capture-MS Homo sapiens
21 ST6GALNAC6 30815
Affinity Capture-MS Homo sapiens
22 WRAP73 49856
Affinity Capture-MS Homo sapiens
23 CCDC51 79714
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 TRIM21 6737
Affinity Capture-MS Homo sapiens
25 NTRK1 4914
Affinity Capture-MS Homo sapiens
26 PIGT 51604
Affinity Capture-MS Homo sapiens
27 SPRR1B 6699
Affinity Capture-MS Homo sapiens
28 ALDH3A1 218
Affinity Capture-MS Homo sapiens
29 THAP4 51078
Affinity Capture-MS Homo sapiens
30 APTX  
Affinity Capture-MS Homo sapiens
31 DDX39B 7919
Affinity Capture-MS Homo sapiens
32 SETD7 80854
Affinity Capture-MS Homo sapiens
33 CYLD  
Affinity Capture-MS Homo sapiens
34 C1orf68 100129271
Affinity Capture-MS Homo sapiens
35 CASP14 23581
Affinity Capture-MS Homo sapiens
36 SARAF  
Affinity Capture-MS Homo sapiens
37 FANCD2  
Affinity Capture-MS Homo sapiens
38 VWA3B 200403
Affinity Capture-MS Homo sapiens
39 METTL14  
Affinity Capture-MS Homo sapiens
40 ZUFSP 221302
Affinity Capture-MS Homo sapiens
41 SRSF1 6426
Affinity Capture-MS Homo sapiens
42 ARG2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 CD274 29126
Affinity Capture-MS Homo sapiens
44 NPPA  
Affinity Capture-MS Homo sapiens
45 ZC3HC1  
Affinity Capture-MS Homo sapiens
46 HNRNPA1 3178
Affinity Capture-MS Homo sapiens
47 CSTA 1475
Affinity Capture-MS Homo sapiens
48 SUZ12  
Affinity Capture-MS Homo sapiens
49 C21orf59 56683
Affinity Capture-MS Homo sapiens
50 FABP5 2171
Affinity Capture-MS Homo sapiens
51 RPA3 6119
Affinity Capture-MS Homo sapiens
52 BLMH 642
Affinity Capture-MS Homo sapiens
53 UBE2J2 118424
Affinity Capture-MS Homo sapiens
54 BMI1  
Affinity Capture-MS Homo sapiens
55 EHF  
Affinity Capture-MS Homo sapiens
56 RIPPLY3  
Affinity Capture-MS Homo sapiens
57 CCDC8  
Affinity Capture-MS Homo sapiens
58 DSP 1832
Affinity Capture-MS Homo sapiens
59 SPICE1  
Affinity Capture-MS Homo sapiens
60 ALDH4A1 8659
Two-hybrid Homo sapiens
61 JUP 3728
Affinity Capture-MS Homo sapiens
62 TP53 7157
Affinity Capture-MS Homo sapiens
63 POLR2L 5441
Affinity Capture-MS Homo sapiens
64 SH2D3A  
Affinity Capture-MS Homo sapiens
65 MCL1 4170
Affinity Capture-MS Homo sapiens
66 RPA1 6117
Affinity Capture-MS Homo sapiens
67 CDSN 1041
Affinity Capture-MS Homo sapiens
68 PHF8  
Affinity Capture-MS Homo sapiens
69 DSC1 1823
Affinity Capture-MS Homo sapiens
70 ATG101  
Affinity Capture-MS Homo sapiens
71 PTDSS1 9791
Affinity Capture-MS Homo sapiens
72 DCD 117159
Affinity Capture-MS Homo sapiens
73 ERCC3  
Affinity Capture-MS Homo sapiens
74 TRIM37  
Proximity Label-MS Homo sapiens
75 EZH2  
Affinity Capture-MS Homo sapiens
76 TGM3 7053
Affinity Capture-MS Homo sapiens
77 SERPINB12 89777
Affinity Capture-MS Homo sapiens
78 RAD21 5885
Affinity Capture-Western Homo sapiens
79 TSPAN6 7105
Affinity Capture-MS Homo sapiens
80 GPR18  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 XRCC6 2547
Proximity Label-MS Homo sapiens
82 OR2A4 79541
Affinity Capture-MS Homo sapiens
83 ANXA2 302
Affinity Capture-MS Homo sapiens
84 CCR1  
Affinity Capture-MS Homo sapiens
85 GALNT9  
Affinity Capture-MS Homo sapiens
86 PPP3CC 5533
Affinity Capture-MS Homo sapiens
87 FLG2 388698
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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