Gene description for SETD7
Gene name SET domain containing (lysine methyltransferase) 7
Gene symbol SETD7
Other names/aliases KMT7
SET7
SET7/9
SET9
Species Homo sapiens
 Database cross references - SETD7
ExoCarta ExoCarta_80854
Vesiclepedia VP_80854
Entrez Gene 80854
HGNC 30412
MIM 606594
UniProt Q8WTS6  
 SETD7 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Endothelial cells 26027894    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for SETD7
Molecular Function
    p53 binding GO:0002039 IPI
    chromatin binding GO:0003682 IEA
    protein binding GO:0005515 IPI
    protein-lysine N-methyltransferase activity GO:0016279 IBA
    protein-lysine N-methyltransferase activity GO:0016279 IDA
    histone methyltransferase activity GO:0042054 IDA
    histone H3 methyltransferase activity GO:0140938 IBA
    histone H3 methyltransferase activity GO:0140938 IDA
    histone H3K4 monomethyltransferase activity GO:0140945 IEA
Biological Process
    chromatin organization GO:0006325 NAS
    chromatin remodeling GO:0006338 IEA
    DNA damage response GO:0006974 IDA
    peptidyl-lysine monomethylation GO:0018026 IDA
    peptidyl-lysine dimethylation GO:0018027 IDA
    response to ethanol GO:0045471 IEA
    positive regulation of DNA-templated transcription GO:0045893 IBA
    heterochromatin organization GO:0070828 IBA
    heterochromatin organization GO:0070828 IDA
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleoplasm GO:0005654 TAS
    chromosome GO:0005694 IBA
    chromosome GO:0005694 IDA
    nucleolus GO:0005730 IDA
 Experiment description of studies that identified SETD7 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 226
MISEV standards
✔
EM
Biophysical techniques
✔
GAPDH|CD9|FLOT1
Enriched markers
✔
LMNA|H2AFX|ATP5A1|TOMM20
Negative markers
✘ Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description "Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting"
Authors "Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar"
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
6
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SETD7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 A1BG 1
Two-hybrid Homo sapiens
2 RELA 5970
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
3 TAF6 6878
Affinity Capture-Western Homo sapiens
4 FAM189B  
Affinity Capture-MS Homo sapiens
5 CHCHD2P9  
Affinity Capture-MS Homo sapiens
6 CASP14 23581
Affinity Capture-MS Homo sapiens
7 ANXA2 302
Affinity Capture-MS Homo sapiens
8 TP53 7157
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Co-crystal Structure Homo sapiens
Two-hybrid Homo sapiens
9 HIST1H3A 8350
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Co-crystal Structure Homo sapiens
Biochemical Activity Homo sapiens
10 SMAD7  
Biochemical Activity Homo sapiens
11 H3F3A 3020
Biochemical Activity Homo sapiens
12 MYL6 4637
Affinity Capture-MS Homo sapiens
13 ESR1  
Protein-peptide Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
14 PRNP 5621
Affinity Capture-MS Homo sapiens
15 HIST1H4A 8359
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
16 MED1 5469
Co-fractionation Homo sapiens
17 UBXN7 26043
Affinity Capture-MS Homo sapiens
18 PPM1B 5495
Affinity Capture-MS Homo sapiens
19 UHRF1 29128
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
20 E2F1 1869
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
21 FOXO1  
Affinity Capture-MS Homo sapiens
22 DPY30 84661
Co-fractionation Homo sapiens
23 TAF7  
Affinity Capture-Western Homo sapiens
24 C9orf78 51759
Affinity Capture-MS Homo sapiens
25 SMURF1 57154
Affinity Capture-Western Homo sapiens
26 PTPN2 5771
Affinity Capture-MS Homo sapiens
27 TAF10 6881
Affinity Capture-Western Homo sapiens
Co-crystal Structure Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
28 CAMSAP2  
Proximity Label-MS Homo sapiens
29 ARG1 383
Affinity Capture-MS Homo sapiens
30 KLF4  
Biochemical Activity Homo sapiens
31 SIRT1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
32 SOX2  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
33 HIST3H3 8290
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
34 GTF2E1 2960
Co-fractionation Homo sapiens
35 MYOD1  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
36 DCD 117159
Affinity Capture-MS Homo sapiens
37 TBP  
Affinity Capture-Western Homo sapiens
38 TXN 7295
Affinity Capture-MS Homo sapiens
39 PPP1R12A 4659
Biochemical Activity Homo sapiens
40 SMARCA4 6597
Affinity Capture-Western Homo sapiens
41 SERTAD1  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
42 SETD7 80854
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
43 ZFP41  
Affinity Capture-MS Homo sapiens
44 HIST2H2AC 8338
Affinity Capture-MS Homo sapiens
45 OGT 8473
Reconstituted Complex Homo sapiens
46 RNF111 54778
Affinity Capture-Western Homo sapiens
47 BLMH 642
Affinity Capture-MS Homo sapiens
48 L3MBTL1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
49 NR2F2  
Two-hybrid Homo sapiens
50 MYL12B 103910
Affinity Capture-MS Homo sapiens
51 HIST1H1C 3006
Affinity Capture-MS Homo sapiens
52 STAT3 6774
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
53 AR 367
Affinity Capture-Western Homo sapiens
54 SMURF2 64750
Affinity Capture-Western Homo sapiens
55 TGM3 7053
Affinity Capture-MS Homo sapiens
56 DNMT1 1786
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Co-crystal Structure Homo sapiens
Biochemical Activity Homo sapiens
57 CCR1  
Affinity Capture-MS Homo sapiens
58 STEAP3 55240
Two-hybrid Homo sapiens
59 AGTR1  
Affinity Capture-MS Homo sapiens
60 PRKAR1A 5573
Two-hybrid Homo sapiens
61 MDM2  
Reconstituted Complex Homo sapiens
62 RPL29 6159
Affinity Capture-MS Homo sapiens
63 ARIH1 25820
Affinity Capture-MS Homo sapiens
64 ATRX 546
Co-fractionation Homo sapiens
65 HIF1A 3091
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which SETD7 is involved
PathwayEvidenceSource
Chromatin modifying enzymes TAS Reactome
Chromatin organization TAS Reactome
PKMTs methylate histone lysines TAS Reactome





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