Gene description for SETD7
Gene name SET domain containing (lysine methyltransferase) 7
Gene symbol SETD7
Other names/aliases KMT7
SET7
SET7/9
SET9
Species Homo sapiens
 Database cross references - SETD7
ExoCarta ExoCarta_80854
Entrez Gene 80854
HGNC 30412
MIM 606594
UniProt Q8WTS6  
 SETD7 identified in exosomes derived from the following tissue/cell type
Endothelial cells 26027894    
 Gene ontology annotations for SETD7
Molecular Function
    p53 binding GO:0002039 IPI
    protein binding GO:0005515 IPI
    protein-lysine N-methyltransferase activity GO:0016279 IDA
    histone-lysine N-methyltransferase activity GO:0018024 NAS
Biological Process
    peptidyl-lysine monomethylation GO:0018026 IDA
    heterochromatin organization GO:0070828 IDA
    chromatin modification GO:0016568 NAS
    peptidyl-lysine dimethylation GO:0018027 IDA
    cellular response to DNA damage stimulus GO:0006974 IDA
    transcription, DNA-templated GO:0006351 IEA
    histone lysine methylation GO:0034968 IEA
    regulation of transcription, DNA-templated GO:0006355 IEA
    chromatin organization GO:0006325 TAS
Subcellular Localization
    nucleolus GO:0005730 IDA
    nucleoplasm GO:0005654 TAS
    chromosome GO:0005694 IEA
 Experiment description of studies that identified SETD7 in exosomes
1
Experiment ID 226
ISEV standards
EM
EV Biophysical techniques
GAPDH
EV Cytosolic markers
CD9|FLOT1
EV Membrane markers
LMNA|H2AFX|ATP5A1|TOMM20
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting
Authors Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
 Protein-protein interactions for SETD7
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SETD7 is involved
PathwayEvidenceSource
PKMTs methylate histone lysines TAS Reactome





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