Gene description for SERPINB8
Gene name serpin peptidase inhibitor, clade B (ovalbumin), member 8
Gene symbol SERPINB8
Other names/aliases CAP2
PI8
Species Homo sapiens
 Database cross references - SERPINB8
ExoCarta ExoCarta_5271
Vesiclepedia VP_5271
Entrez Gene 5271
HGNC 8952
MIM 601697
UniProt P50452  
 SERPINB8 identified in exosomes derived from the following tissue/cell type
Chondrocytes 35931686    
Chondrocytes 35931686    
 Gene ontology annotations for SERPINB8
Molecular Function
    protein binding GO:0005515 IPI
    serine-type endopeptidase inhibitor activity GO:0004867 IDA
Biological Process
    negative regulation of endopeptidase activity GO:0010951 IDA
Subcellular Localization
    extracellular space GO:0005615 IBA
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 IDA
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified SERPINB8 in exosomes
1
Experiment ID 494
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD9|CD81|CD151|CD63|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
EV Enriched markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD.
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Osteoarthritic cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 496
MISEV standards
✘ EV Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD.
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Healthy cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SERPINB8
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 BCL2  
Affinity Capture-Western Homo sapiens
2 PRSS1 5644
Reconstituted Complex Homo sapiens
3 FURIN 5045
Reconstituted Complex Homo sapiens
4 CAP1 10487
Invivo Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
5 F10 2159
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which SERPINB8 is involved
PathwayEvidenceSource
Dissolution of Fibrin Clot TAS Reactome





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