Gene description for ZP3
Gene name	zona pellucida glycoprotein 3 (sperm receptor)
Gene symbol	ZP3
Other names/aliases	ZP3A ZP3B ZPC Zp-3
Species	Homo sapiens
Database cross references - ZP3
ExoCarta	ExoCarta_7784
Entrez Gene	7784
HGNC	13189
MIM	182889
UniProt	P21754
ZP3 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723

Gene ontology annotations for ZP3

Molecular Function     manganese ion transmembrane transporter activity GO:0005384 ISS     protein binding GO:0005515 IPI     carbohydrate binding GO:0030246 IDA     signal transducer activity GO:0004871 IMP     acrosin binding GO:0032190 IPI     store-operated calcium channel activity GO:0015279 IDA Biological Process     intracellular signal transduction GO:0035556 IMP     positive regulation of antral ovarian follicle growth GO:2000388 ISS     positive regulation of interleukin-4 production GO:0032753 ISS     positive regulation of type IV hypersensitivity GO:0001809 ISS     intracellular protein transport GO:0006886 ISS     positive regulation of protein kinase B signaling GO:0051897 ISS     positive regulation of inflammatory response GO:0050729 ISS     positive regulation of protein kinase activity GO:0045860 IDA     positive regulation of phosphatidylinositol biosynthetic process GO:0010513 ISS     negative regulation of binding of sperm to zona pellucida GO:2000360 IDA     positive regulation of calcium ion import GO:0090280 IDA     egg coat formation GO:0035803 ISS     manganese ion transport GO:0006828 ISS     positive regulation of acrosomal vesicle exocytosis GO:2000368 IMP     positive regulation of leukocyte migration GO:0002687 ISS     single fertilization GO:0007338 TAS     positive regulation of ovarian follicle development GO:2000386 ISS     positive regulation of interferon-gamma production GO:0032729 ISS     negative regulation of transcription, DNA-templated GO:0045892 ISS     manganese ion transmembrane transport GO:0071421 ISS     oocyte development GO:0048599 ISS     binding of sperm to zona pellucida GO:0007339 TAS     multicellular organism reproduction GO:0032504 TAS     calcium ion transmembrane transport GO:0070588 IDA     blastocyst formation GO:0001825 ISS     positive regulation of transcription, DNA-templated GO:0045893 ISS     positive regulation of humoral immune response GO:0002922 IDA     positive regulation of T cell proliferation GO:0042102 ISS     protein kinase C signaling GO:0070528 IMP     humoral immune response mediated by circulating immunoglobulin GO:0002455 ISS     phosphatidylinositol-mediated signaling GO:0048015 ISS     positive regulation of acrosome reaction GO:2000344 IDA Subcellular Localization     acrosomal vesicle GO:0001669 ISS     outer acrosomal membrane GO:0002081 ISS     extracellular region GO:0005576 TAS     Golgi apparatus GO:0005794 ISS     extracellular matrix GO:0031012 IDA     secretory granule GO:0030141 ISS     perinuclear region of cytoplasm GO:0048471 ISS     integral component of membrane GO:0016021 IEA     plasma membrane GO:0005886 ISS     extracellular space GO:0005615 IMP     proteinaceous extracellular matrix GO:0005578 IEA     cytoplasm GO:0005737 IDA     endoplasmic reticulum GO:0005783 ISS     multivesicular body GO:0005771 ISS