Gene description for ZP3
Gene name	zona pellucida glycoprotein 3 (sperm receptor)
Gene symbol	ZP3
Other names/aliases	ZP3A ZP3B ZPC Zp-3
Species	Homo sapiens
Database cross references - ZP3
ExoCarta	ExoCarta_7784
Vesiclepedia	VP_7784
Entrez Gene	7784
HGNC	13189
MIM	182889
UniProt	P21754
ZP3 identified in sEVs derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723

Gene ontology annotations for ZP3

Molecular Function     extracellular matrix structural constituent GO:0005201 HDA     protein binding GO:0005515 IPI     carbohydrate binding GO:0030246 IDA     acrosin binding GO:0032190 IBA     acrosin binding GO:0032190 IPI     structural constituent of egg coat GO:0035804 ISS     identical protein binding GO:0042802 IPI     receptor ligand activity GO:0048018 ISS Biological Process     positive regulation of type IV hypersensitivity GO:0001809 ISS     blastocyst formation GO:0001825 ISS     humoral immune response mediated by circulating immunoglobulin GO:0002455 ISS     positive regulation of leukocyte migration GO:0002687 ISS     positive regulation of humoral immune response GO:0002922 IDA     signal transduction GO:0007165 IEA     binding of sperm to zona pellucida GO:0007339 IBA     binding of sperm to zona pellucida GO:0007339 IDA     binding of sperm to zona pellucida GO:0007339 IGI     binding of sperm to zona pellucida GO:0007339 IMP     positive regulation of type II interferon production GO:0032729 ISS     positive regulation of interleukin-4 production GO:0032753 ISS     egg coat formation GO:0035803 IBA     egg coat formation GO:0035803 ISS     positive regulation of T cell proliferation GO:0042102 ISS     negative regulation of DNA-templated transcription GO:0045892 ISS     positive regulation of DNA-templated transcription GO:0045893 ISS     oocyte development GO:0048599 ISS     positive regulation of inflammatory response GO:0050729 ISS     positive regulation of acrosome reaction GO:2000344 IBA     positive regulation of acrosome reaction GO:2000344 IDA     negative regulation of binding of sperm to zona pellucida GO:2000360 IDA     positive regulation of acrosomal vesicle exocytosis GO:2000368 IDA     positive regulation of acrosomal vesicle exocytosis GO:2000368 IMP     positive regulation of ovarian follicle development GO:2000386 ISS     positive regulation of antral ovarian follicle growth GO:2000388 ISS Subcellular Localization     extracellular region GO:0005576 TAS     extracellular space GO:0005615 IMP     plasma membrane GO:0005886 ISS     extracellular matrix GO:0031012 IBA     egg coat GO:0035805 IDA     collagen-containing extracellular matrix GO:0062023 HDA     collagen-containing extracellular matrix GO:0062023 IDA