Gene description for LSM1
Gene name LSM1, U6 small nuclear RNA associated
Gene symbol LSM1
Other names/aliases CASM
YJL124C
Species Homo sapiens
 Database cross references - LSM1
ExoCarta ExoCarta_27257
Vesiclepedia VP_27257
Entrez Gene 27257
HGNC 20472
MIM 607281
UniProt O15116  
 LSM1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for LSM1
Molecular Function
    RNA binding GO:0003723 HDA
    mRNA binding GO:0003729 IBA
    protein binding GO:0005515 IPI
    pre-mRNA binding GO:0036002 IEA
Biological Process
    deadenylation-dependent decapping of nuclear-transcribed mRNA GO:0000290 IBA
    RNA splicing, via transesterification reactions GO:0000375 TAS
    mRNA processing GO:0006397 IEA
    RNA splicing GO:0008380 TAS
    stem cell population maintenance GO:0019827 IEA
    neuron differentiation GO:0030182 IEA
    negative regulation of neuron differentiation GO:0045665 IEA
    histone mRNA catabolic process GO:0071044 IMP
Subcellular Localization
    P-body GO:0000932 IBA
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 TAS
    axon GO:0030424 IEA
    dendrite GO:0030425 IEA
    neuronal cell body GO:0043025 IEA
    Lsm1-7-Pat1 complex GO:1990726 IBA
    ribonucleoprotein complex GO:1990904 IEA
 Experiment description of studies that identified LSM1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for LSM1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 P3H1 64175
Co-fractionation Homo sapiens
2 CLTB 1212
Affinity Capture-MS Homo sapiens
3 DDX6 1656
Affinity Capture-MS Homo sapiens
4 EXOSC6 118460
Two-hybrid Homo sapiens
5 GLUD1 2746
Two-hybrid Homo sapiens
6 CLIC1 1192
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
7 RRP1B 23076
Two-hybrid Homo sapiens
8 HK1 3098
Cross-Linking-MS (XL-MS) Homo sapiens
9 SNRPE 6635
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
10 XPO1 7514
Affinity Capture-MS Homo sapiens
11 TMEM214 54867
Two-hybrid Homo sapiens
12 LSM2 57819
Two-hybrid Homo sapiens
Co-fractionation Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
13 C9orf114  
Affinity Capture-MS Homo sapiens
14 IL36B  
Affinity Capture-MS Homo sapiens
15 DDX17 10521
Co-fractionation Homo sapiens
16 ACTC1 70
Proximity Label-MS Homo sapiens
17 PSMB8 5696
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
18 HNRNPA2B1 3181
Affinity Capture-MS Homo sapiens
19 FOXA1  
Affinity Capture-MS Homo sapiens
20 FGB 2244
Affinity Capture-MS Homo sapiens
21 UBE3A 7337
Co-fractionation Homo sapiens
22 LSM4 25804
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
23 UXT 8409
Two-hybrid Homo sapiens
24 ARHGAP18 93663
Affinity Capture-MS Homo sapiens
25 INPPL1 3636
Co-fractionation Homo sapiens
26 PI4KB 5298
Affinity Capture-MS Homo sapiens
27 WHSC1 7468
Co-fractionation Homo sapiens
28 PRPF3  
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
29 LSM5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 SNRPF 6636
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 SNRPD2 6633
Co-fractionation Homo sapiens
32 BEX5  
Two-hybrid Homo sapiens
33 N4BP1  
Two-hybrid Homo sapiens
34 GRHPR 9380
Two-hybrid Homo sapiens
35 AGR3 155465
Two-hybrid Homo sapiens
36 PAN2  
Affinity Capture-MS Homo sapiens
37 TCL1B  
Two-hybrid Homo sapiens
38 DAPL1 92196
Two-hybrid Homo sapiens
39 LSM3 27258
Two-hybrid Homo sapiens
Co-fractionation Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
40 HSP90AA1 3320
Two-hybrid Homo sapiens
41 PCID2 55795
Co-fractionation Homo sapiens
42 CLTA 1211
Affinity Capture-MS Homo sapiens
43 LSM7  
Affinity Capture-MS Homo sapiens
44 WASL 8976
Co-fractionation Homo sapiens
45 MCCD1  
Two-hybrid Homo sapiens
46 PRPF4 9128
Co-fractionation Homo sapiens
47 PATL1 219988
Two-hybrid Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
48 AGR2 10551
Two-hybrid Homo sapiens
49 LSM6 11157
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 PSMB5 5693
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
51 BCL6  
Affinity Capture-MS Homo sapiens
52 SOWAHA  
Affinity Capture-MS Homo sapiens
53 SMC1A 8243
Affinity Capture-MS Homo sapiens
54 ZMYM1 79830
Affinity Capture-MS Homo sapiens
55 NARS 4677
Two-hybrid Homo sapiens
56 DDX58 23586
Affinity Capture-RNA Homo sapiens
57 LSM14A 26065
Affinity Capture-MS Homo sapiens
58 RAB14 51552
Affinity Capture-MS Homo sapiens
59 UPF2 26019
Two-hybrid Homo sapiens
60 MPDU1 9526
Two-hybrid Homo sapiens
61 GSTA4  
Two-hybrid Homo sapiens
62 VPS11 55823
Two-hybrid Homo sapiens
63 SNRPD3 6634
Co-fractionation Homo sapiens
64 EXOSC8  
Two-hybrid Homo sapiens
View the network image/svg+xml



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