Gene description for LSM1
Gene name LSM1, U6 small nuclear RNA associated
Gene symbol LSM1
Other names/aliases CASM
YJL124C
Species Homo sapiens
 Database cross references - LSM1
ExoCarta ExoCarta_27257
Vesiclepedia VP_27257
Entrez Gene 27257
HGNC 20472
MIM 607281
UniProt O15116  
 LSM1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for LSM1
Molecular Function
    protein binding GO:0005515 IPI
    poly(A) RNA binding GO:0044822 IDA
    RNA cap binding GO:0000339 IBA
Biological Process
    histone mRNA catabolic process GO:0071044 IMP
    RNA splicing, via transesterification reactions GO:0000375 TAS
    exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay GO:0043928 TAS
    nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 TAS
    gene expression GO:0010467 TAS
    deadenylation-dependent decapping of nuclear-transcribed mRNA GO:0000290 IBA
    RNA splicing GO:0008380 TAS
    mRNA processing GO:0006397 IEA
Subcellular Localization
    nucleus GO:0005634 IDA
    cytosol GO:0005829 TAS
    cytoplasmic mRNA processing body GO:0000932 IBA
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified LSM1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for LSM1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 EXOSC6 118460
Two-hybrid Homo sapiens
2 PSMB8  
Two-hybrid Homo sapiens
3 SMN1 6606
Affinity Capture-MS Homo sapiens
Invitro Homo sapiens
4 TMEM214 54867
Two-hybrid Homo sapiens
5 LSM4 25804
Affinity Capture-MS Homo sapiens
Invitro Homo sapiens
6 UXT 8409
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
7 HSP90AA1 3320
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
8 LSM5 23658
Affinity Capture-MS Homo sapiens
Invitro Homo sapiens
9 GRHPR 9380
Two-hybrid Homo sapiens
10 LSM7  
Invitro Homo sapiens
11 LSM3 27258
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
12 CLIC1  
Two-hybrid Homo sapiens
13 LSM6 11157
Affinity Capture-MS Homo sapiens
Invitro Homo sapiens
14 PSMB5 5693
Two-hybrid Homo sapiens
15 LSM2  
Invitro Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
16 NARS 4677
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
17 UPF2 26019
Two-hybrid Homo sapiens
18 NDUFAF3 25915
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
19 FAM136A 84908
Affinity Capture-MS Homo sapiens
20 EXOSC8  
Two-hybrid Homo sapiens
21 VPS11 55823
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
22 N4BP1  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which LSM1 is involved
PathwayEvidenceSource
mRNA decay by 5' to 3' exoribonuclease TAS Reactome





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