Gene description for DAPL1
Gene name death associated protein-like 1
Gene symbol DAPL1
Other names/aliases -
Species Homo sapiens
 Database cross references - DAPL1
ExoCarta ExoCarta_92196
Vesiclepedia VP_92196
Entrez Gene 92196
HGNC 21490
UniProt A0PJW8  
 DAPL1 identified in sEVs derived from the following tissue/cell type
Chondrocytes 35931686    
Chondrocytes 35931686    
 Gene ontology annotations for DAPL1
Molecular Function
    protein binding GO:0005515 IPI
    translation repressor activity GO:0030371 ISS
    translation initiation factor binding GO:0031369 ISS
    ribosome binding GO:0043022 IBA
    ribosome binding GO:0043022 ISS
Biological Process
    negative regulation of autophagy GO:0010507 IBA
    cell differentiation GO:0030154 IEA
    cellular response to amino acid starvation GO:0034198 IBA
    apoptotic signaling pathway GO:0097190 IBA
    ribosome hibernation GO:0141014 IBA
    ribosome hibernation GO:0141014 ISS
    negative regulation of CD8-positive, alpha-beta T cell activation GO:2001186 ISS
 Experiment description of studies that identified DAPL1 in sEVs
1
Experiment ID 497
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 498
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for DAPL1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ZIC1  
Two-hybrid Homo sapiens
2 LSM1 27257
Two-hybrid Homo sapiens
3 TRIM55  
Two-hybrid Homo sapiens
4 TRIM63  
Two-hybrid Homo sapiens
5 TSR2  
Two-hybrid Homo sapiens
6 FHL2 2274
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which DAPL1 is involved
No pathways found





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