Gene description for LSM14A
Gene name LSM14A, SCD6 homolog A (S. cerevisiae)
Gene symbol LSM14A
Other names/aliases C19orf13
FAM61A
RAP55
RAP55A
Species Homo sapiens
 Database cross references - LSM14A
ExoCarta ExoCarta_26065
Vesiclepedia VP_26065
Entrez Gene 26065
HGNC 24489
MIM 610677
UniProt Q8ND56  
 LSM14A identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for LSM14A
Molecular Function
    double-stranded DNA binding GO:0003690 IEA
    RNA binding GO:0003723 HDA
    double-stranded RNA binding GO:0003725 IEA
    single-stranded RNA binding GO:0003727 IEA
    mRNA binding GO:0003729 IBA
    protein binding GO:0005515 IPI
Biological Process
    negative regulation of translation GO:0017148 IMP
    P-body assembly GO:0033962 IBA
    P-body assembly GO:0033962 IDA
    P-body assembly GO:0033962 IMP
    stress granule assembly GO:0034063 IBA
    RIG-I signaling pathway GO:0039529 IEA
    defense response to virus GO:0051607 IEA
    positive regulation of type I interferon-mediated signaling pathway GO:0060340 IEA
    mitotic spindle assembly GO:0090307 IMP
Subcellular Localization
    P-body GO:0000932 IBA
    P-body GO:0000932 IDA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IDA
    cytoplasmic stress granule GO:0010494 IDA
    cytoplasmic ribonucleoprotein granule GO:0036464 IDA
    mitotic spindle GO:0072686 IDA
    ribonucleoprotein complex GO:1990904 IEA
 Experiment description of studies that identified LSM14A in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for LSM14A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Co-fractionation Homo sapiens
2 INSIG1  
Affinity Capture-MS Homo sapiens
3 MRPS27 23107
Affinity Capture-MS Homo sapiens
4 UBE2H 7328
Affinity Capture-MS Homo sapiens
5 MRPL48  
Affinity Capture-MS Homo sapiens
6 DCP1B  
Affinity Capture-MS Homo sapiens
7 STRAP 11171
Affinity Capture-MS Homo sapiens
8 ARHGAP11B  
Affinity Capture-MS Homo sapiens
9 ZFR 51663
Affinity Capture-MS Homo sapiens
10 CSNK2A1 1457
Biochemical Activity Homo sapiens
11 HNRNPR 10236
Affinity Capture-MS Homo sapiens
12 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
13 SOX2  
Affinity Capture-MS Homo sapiens
14 APEX1 328
Affinity Capture-RNA Homo sapiens
15 SEPT9 10801
Affinity Capture-MS Homo sapiens
16 EIF4ENIF1 56478
Affinity Capture-MS Homo sapiens
17 IGF2BP3 10643
Affinity Capture-MS Homo sapiens
18 MRPL20 55052
Affinity Capture-MS Homo sapiens
19 PC 5091
Co-fractionation Homo sapiens
20 KLF8  
Affinity Capture-MS Homo sapiens
21 COL8A1 1295
Affinity Capture-MS Homo sapiens
22 MRPL12 6182
Affinity Capture-MS Homo sapiens
23 FBL 2091
Proximity Label-MS Homo sapiens
24 KLF15  
Affinity Capture-MS Homo sapiens
25 ANGEL1  
Affinity Capture-MS Homo sapiens
26 PEA15 8682
Affinity Capture-MS Homo sapiens
27 GAGE2E 26749
Affinity Capture-MS Homo sapiens
28 KIF2C 11004
Affinity Capture-MS Homo sapiens
29 ATG16L1 55054
Affinity Capture-MS Homo sapiens
30 DDX6 1656
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 MRPS7 51081
Affinity Capture-MS Homo sapiens
32 MYCN  
Affinity Capture-MS Homo sapiens
33 SOX5 6660
Affinity Capture-MS Homo sapiens
34 LSM1 27257
Affinity Capture-MS Homo sapiens
35 LSM12 124801
Affinity Capture-MS Homo sapiens
36 ATXN2 6311
Affinity Capture-MS Homo sapiens
37 INSIG2  
Affinity Capture-MS Homo sapiens
38 CPEB1  
Proximity Label-MS Homo sapiens
39 KLF16  
Affinity Capture-MS Homo sapiens
40 GARS 2617
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
41 EDC4 23644
Affinity Capture-MS Homo sapiens
42 SOX6  
Affinity Capture-MS Homo sapiens
43 KLF5  
Affinity Capture-MS Homo sapiens
44 TMEM14B  
Affinity Capture-MS Homo sapiens
45 TLX3  
Affinity Capture-MS Homo sapiens
46 LSM14B 149986
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 Lsm14a  
Affinity Capture-MS Mus musculus
48 MRPL14 64928
Affinity Capture-MS Homo sapiens
49 MAPRE1 22919
Proximity Label-MS Homo sapiens
50 IFI27L1  
Affinity Capture-MS Homo sapiens
51 CIRBP 1153
Co-fractionation Homo sapiens
52 DCP1A 55802
Affinity Capture-MS Homo sapiens
53 SYNCRIP 10492
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
54 DDX1 1653
Co-fractionation Homo sapiens
55 HECTD1 25831
Affinity Capture-MS Homo sapiens
56 HNRNPA3 220988
Affinity Capture-MS Homo sapiens
57 CEBPA  
Protein-peptide Homo sapiens
58 OGT 8473
Reconstituted Complex Homo sapiens
59 HNRNPDL 9987
Co-fractionation Homo sapiens
60 TLX2  
Affinity Capture-MS Homo sapiens
61 SFPQ 6421
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 NUP37 79023
Affinity Capture-MS Homo sapiens
63 DAP3 7818
Affinity Capture-MS Homo sapiens
64 XPO1 7514
Affinity Capture-MS Homo sapiens
65 NTRK1 4914
Affinity Capture-MS Homo sapiens
66 PHACTR3  
Affinity Capture-MS Homo sapiens
67 PRMT8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 CD274 29126
Affinity Capture-MS Homo sapiens
69 EGFR 1956
Affinity Capture-MS Homo sapiens
70 GADD45GIP1  
Affinity Capture-MS Homo sapiens
71 EIF4E 1977
Affinity Capture-MS Homo sapiens
72 SOX15  
Affinity Capture-MS Homo sapiens
73 MRPL1  
Affinity Capture-MS Homo sapiens
74 HNRNPA1 3178
Affinity Capture-MS Homo sapiens
75 MYC  
Affinity Capture-MS Homo sapiens
76 HECW2  
Affinity Capture-MS Homo sapiens
77 FXR2 9513
Affinity Capture-MS Homo sapiens
78 HNRNPAB 3182
Affinity Capture-MS Homo sapiens
79 HNRNPU 3192
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
80 RAE1 8480
Affinity Capture-MS Homo sapiens
81 AHSA1 10598
Affinity Capture-MS Homo sapiens
82 LBR 3930
Affinity Capture-MS Homo sapiens
83 YBX1 4904
Affinity Capture-MS Homo sapiens
84 MRPL42  
Affinity Capture-MS Homo sapiens
85 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
86 ILF3 3609
Affinity Capture-MS Homo sapiens
87 FBXL6  
Affinity Capture-MS Homo sapiens
88 TP53 7157
Affinity Capture-MS Homo sapiens
89 TCERG1 10915
Affinity Capture-MS Homo sapiens
90 MRPL53  
Affinity Capture-MS Homo sapiens
91 ARHGAP18 93663
Affinity Capture-MS Homo sapiens
92 EDC3 80153
Affinity Capture-MS Homo sapiens
93 DDX58 23586
Affinity Capture-RNA Homo sapiens
94 UFL1 23376
Affinity Capture-MS Homo sapiens
95 MRPS30 10884
Affinity Capture-MS Homo sapiens
96 E2F4  
Affinity Capture-MS Homo sapiens
97 HNRNPL 3191
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
98 SORT1 6272
Affinity Capture-MS Homo sapiens
99 CLTA 1211
Affinity Capture-MS Homo sapiens
100 TMC4  
Affinity Capture-MS Homo sapiens
101 C1QBP 708
Affinity Capture-MS Homo sapiens
102 ARHGAP23 57636
Affinity Capture-MS Homo sapiens
103 VDAC3 7419
Affinity Capture-MS Homo sapiens
104 MRPS22 56945
Affinity Capture-MS Homo sapiens
105 PTCH1  
Affinity Capture-MS Homo sapiens
106 PRMT1 3276
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
107 SEC31A 22872
Co-fractionation Homo sapiens
108 ALDOA 226
Cross-Linking-MS (XL-MS) Homo sapiens
View the network image/svg+xml
 Pathways in which LSM14A is involved
No pathways found





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