Gene description for UPP1
Gene name uridine phosphorylase 1
Gene symbol UPP1
Other names/aliases UDRPASE
UP
UPASE
UPP
Species Homo sapiens
 Database cross references - UPP1
ExoCarta ExoCarta_7378
Entrez Gene 7378
HGNC 12576
MIM 191730
UniProt Q16831  
 UPP1 identified in exosomes derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
 Gene ontology annotations for UPP1
Molecular Function
    uridine phosphorylase activity GO:0004850 IEA
Biological Process
    nucleobase-containing small molecule metabolic process GO:0055086 TAS
    cellular response to glucose starvation GO:0042149 IEA
    pyrimidine nucleoside salvage GO:0043097 TAS
    UMP salvage GO:0044206 IEA
    nucleobase-containing compound metabolic process GO:0006139 TAS
    pyrimidine nucleoside catabolic process GO:0046135 TAS
    uridine metabolic process GO:0046108 IEA
    nucleotide catabolic process GO:0009166 IEA
    pyrimidine nucleobase metabolic process GO:0006206 TAS
    small molecule metabolic process GO:0044281 TAS
Subcellular Localization
    cytosol GO:0005829 TAS
 Experiment description of studies that identified UPP1 in exosomes
1
Experiment ID 191
ISEV standards
✘ EV Biophysical techniques
✔
Alix
EV Cytosolic markers
✔
CD81|CD9
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for UPP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 VIM 7431
Invivo Homo sapiens
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which UPP1 is involved
PathwayEvidenceSource
Pyrimidine catabolism TAS Reactome
Pyrimidine salvage reactions TAS Reactome





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