Gene description for RIC8B
Gene name RIC8 guanine nucleotide exchange factor B
Gene symbol RIC8B
Other names/aliases RIC8
hSyn
Species Homo sapiens
 Database cross references - RIC8B
ExoCarta ExoCarta_55188
Entrez Gene 55188
HGNC 25555
MIM 609147
UniProt Q9NVN3  
 RIC8B identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for RIC8B
Molecular Function
    GTPase activator activity GO:0005096 IBA
    guanyl-nucleotide exchange factor activity GO:0005085 IBA
    G-protein alpha-subunit binding GO:0001965 IDA
Biological Process
    regulation of G-protein coupled receptor protein signaling pathway GO:0008277 IDA
    G-protein coupled receptor signaling pathway GO:0007186 IBA
    positive regulation of GTPase activity GO:0043547 IBA
Subcellular Localization
    cell cortex GO:0005938 IEA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IDA
    plasma membrane GO:0005886 IDA
    centrosome GO:0005813 IDA
 Experiment description of studies that identified RIC8B in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for RIC8B
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which RIC8B is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here