Gene description for VWA2
Gene name von Willebrand factor A domain containing 2
Gene symbol VWA2
Other names/aliases AMACO
CCSP-2
NET42
Species Homo sapiens
 Database cross references - VWA2
ExoCarta ExoCarta_340706
Vesiclepedia VP_340706
Entrez Gene 340706
HGNC 24709
UniProt Q5GFL6  
 VWA2 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 34887515    
Saliva 19199708    
 Gene ontology annotations for VWA2
Molecular Function
    calcium ion binding GO:0005509 IEA
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IDA
Biological Process
    calcium-independent cell-matrix adhesion GO:0007161 IBA
    regulation of insulin receptor signaling pathway GO:0046626 IMP
Subcellular Localization
    basement membrane GO:0005604 IBA
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 IDA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified VWA2 in exosomes
1
Experiment ID 1203
MISEV standards
EM
Biophysical techniques
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
2
Experiment ID 66
MISEV standards
IEM
Biophysical techniques
TSG101|Alix|CD63|CD81
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors "Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR"
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for VWA2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 STUB1 10273
Affinity Capture-MS Homo sapiens
2 HERC1 8925
Affinity Capture-MS Homo sapiens
3 MTR 4548
Affinity Capture-MS Homo sapiens
4 TCP11L1 55346
Affinity Capture-MS Homo sapiens
5 CCZ1 51622
Affinity Capture-MS Homo sapiens
6 TUBB 203068
Affinity Capture-MS Homo sapiens
7 TRAF2 7186
Two-hybrid Homo sapiens
8 HSPA8 3312
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 RIC8B 55188
Affinity Capture-MS Homo sapiens
10 CPNE7 27132
Affinity Capture-MS Homo sapiens
11 DDX19B 11269
Affinity Capture-MS Homo sapiens
12 MISP 126353
Affinity Capture-MS Homo sapiens
13 NUDCD3 23386
Affinity Capture-MS Homo sapiens
14 MARCH7  
Affinity Capture-MS Homo sapiens
15 WDR73  
Affinity Capture-MS Homo sapiens
16 TUBA1A 7846
Affinity Capture-MS Homo sapiens
17 UBB 7314
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 TCTEX1D2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 TANGO6 79613
Affinity Capture-MS Homo sapiens
20 DDA1  
Affinity Capture-MS Homo sapiens
21 GNB2 2783
Affinity Capture-MS Homo sapiens
22 CAD 790
Affinity Capture-MS Homo sapiens
23 PPP2R5D 5528
Affinity Capture-MS Homo sapiens
24 TUBB7P 56604
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 RECQL4  
Affinity Capture-MS Homo sapiens
26 KLF15  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 CBWD1 55871
Affinity Capture-MS Homo sapiens
28 GET4 51608
Affinity Capture-MS Homo sapiens
29 WDR47  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 TUBB8 347688
Affinity Capture-MS Homo sapiens
31 HSPA2 3306
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which VWA2 is involved
No pathways found





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