Gene description for PPP2R5D
Gene name protein phosphatase 2, regulatory subunit B', delta
Gene symbol PPP2R5D
Other names/aliases B56D
MRD35
Species Homo sapiens
 Database cross references - PPP2R5D
ExoCarta ExoCarta_5528
Vesiclepedia VP_5528
Entrez Gene 5528
HGNC 9312
MIM 601646
UniProt Q14738  
 PPP2R5D identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Chondrocytes 35931686    
Chondrocytes 35931686    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for PPP2R5D
Molecular Function
    protein binding GO:0005515 IPI
    protein phosphatase regulator activity GO:0019888 IDA
    protein phosphatase activator activity GO:0072542 IBA
Biological Process
    signal transduction GO:0007165 IEA
    nervous system development GO:0007399 TAS
    meiotic sister chromatid cohesion GO:0051177 IBA
Subcellular Localization
    protein phosphatase type 2A complex GO:0000159 IBA
    nucleus GO:0005634 IBA
    nucleoplasm GO:0005654 TAS
    cytosol GO:0005829 IBA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified PPP2R5D in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 497
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 498
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
7
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
9
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
10
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for PPP2R5D
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PTPRF 5792
Co-fractionation Homo sapiens
2 FOXF1 2294
Affinity Capture-MS Homo sapiens
3 HNRNPC 3183
Co-fractionation Homo sapiens
4 Pxdc1  
Affinity Capture-MS Mus musculus
5 TPGS1  
Affinity Capture-MS Homo sapiens
6 HOOK1  
Proximity Label-MS Homo sapiens
7 ATG9A 79065
Proximity Label-MS Homo sapiens
8 ARPC2 10109
Co-fractionation Homo sapiens
9 CSNK1A1 1452
Co-fractionation Homo sapiens
10 DHPS 1725
Co-fractionation Homo sapiens
11 DEC1  
Two-hybrid Homo sapiens
12 C9orf78 51759
Affinity Capture-MS Homo sapiens
13 NTNG1  
Affinity Capture-MS Homo sapiens
14 CHEK2  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
15 BTBD6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 CELA3A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 PPP2R1B 5519
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
18 RDX 5962
Co-fractionation Homo sapiens
19 LHFPL2 10184
Affinity Capture-MS Homo sapiens
20 PRDX2 7001
Co-fractionation Homo sapiens
21 LPP 4026
Co-fractionation Homo sapiens
22 GOPC 57120
Co-fractionation Homo sapiens
23 DGCR2 9993
Affinity Capture-MS Homo sapiens
24 FSD2 123722
Two-hybrid Homo sapiens
25 CSNK2B 1460
Two-hybrid Homo sapiens
26 PLS3 5358
Co-fractionation Homo sapiens
27 NIF3L1 60491
Co-fractionation Homo sapiens
28 MSN 4478
Co-fractionation Homo sapiens
29 GPR17 2840
Affinity Capture-MS Homo sapiens
30 GSK3B 2932
Affinity Capture-Western Homo sapiens
31 FEN1 2237
Co-fractionation Homo sapiens
32 YWHAB 7529
Affinity Capture-MS Homo sapiens
33 PFN1 5216
Proximity Label-MS Homo sapiens
34 DNASE2B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 WNT3A 89780
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 CLOCK  
Two-hybrid Homo sapiens
37 PPP1CA 5499
Affinity Capture-Western Homo sapiens
38 RORC 6097
Two-hybrid Homo sapiens
39 TPD52L2 7165
Co-fractionation Homo sapiens
40 CRY1  
Two-hybrid Homo sapiens
41 TGM2 7052
Affinity Capture-MS Homo sapiens
42 RDH8  
Affinity Capture-MS Homo sapiens
43 ACACA 31
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
44 PLOD2 5352
Co-fractionation Homo sapiens
45 DNAJB7  
Affinity Capture-MS Homo sapiens
46 CAST 831
Co-fractionation Homo sapiens
47 Ppp2ca 19052
Affinity Capture-MS Mus musculus
48 Sept11  
Affinity Capture-MS Mus musculus
49 RPA2 6118
Co-fractionation Homo sapiens
50 NTRK1 4914
Affinity Capture-MS Homo sapiens
51 HAND1  
Two-hybrid Homo sapiens
52 BMP7 655
Affinity Capture-MS Homo sapiens
53 PPP2CA 5515
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
54 DYDC1  
Two-hybrid Homo sapiens
55 BICD2 23299
Proximity Label-MS Homo sapiens
56 CRY2  
Two-hybrid Homo sapiens
57 CSNK1E 1454
Two-hybrid Homo sapiens
58 HECTD1 25831
Co-fractionation Homo sapiens
59 GRIN2A  
Affinity Capture-MS Homo sapiens
60 CTR9 9646
Affinity Capture-MS Homo sapiens
61 CCDC61  
Affinity Capture-MS Homo sapiens
62 DNAJC12  
Proximity Label-MS Homo sapiens
63 CCNG2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 SPRYD7 57213
Affinity Capture-MS Homo sapiens
65 FAM43A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 KLHL14 57565
Affinity Capture-MS Homo sapiens
67 Ppp2r1a 51792
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
68 ARPC1B 10095
Co-fractionation Homo sapiens
69 BAG2 9532
Affinity Capture-MS Homo sapiens
70 PON2 5445
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 SGOL1  
Affinity Capture-MS Homo sapiens
72 LARS 51520
Co-fractionation Homo sapiens
73 XPO6 23214
Co-fractionation Homo sapiens
74 RPS27 6232
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 RRM2 6241
Co-fractionation Homo sapiens
76 FKBP5 2289
Affinity Capture-MS Homo sapiens
77 PPP2R1A 5518
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 USP47 55031
Affinity Capture-MS Homo sapiens
79 HAND2  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
80 RPL35A 6165
Affinity Capture-MS Homo sapiens
81 DDRGK1 65992
Affinity Capture-MS Homo sapiens
82 CCNG1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 USHBP1  
Two-hybrid Homo sapiens
84 GPR37  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
85 PPP2R5A 5525
Co-fractionation Homo sapiens
86 PPFIA1 8500
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
87 PFDN5 5204
Co-fractionation Homo sapiens
88 PPP2CB 5516
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
89 PPME1 51400
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 DUSP19  
Affinity Capture-MS Homo sapiens
91 ARL2 402
Co-purification Homo sapiens
92 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
93 PPP4C 5531
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
94 TTC27 55622
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
95 HLA-DRA 3122
Affinity Capture-MS Homo sapiens
96 PPP2R2A 5520
Co-fractionation Homo sapiens
97 SLC39A7 7922
Affinity Capture-MS Homo sapiens
98 MEN1 4221
Affinity Capture-MS Homo sapiens
99 CCHCR1  
Affinity Capture-MS Homo sapiens
100 DNAAF5 54919
Co-fractionation Homo sapiens
101 SQSTM1 8878
Proximity Label-MS Homo sapiens
102 PDDC1 347862
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
103 PRR14  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
104 RAD9B  
Affinity Capture-MS Homo sapiens
105 WIF1 11197
Affinity Capture-MS Homo sapiens
106 BCAT1 586
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
107 FBXL3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
108 VWA2 340706
Affinity Capture-MS Homo sapiens
109 SH3GLB1 51100
Co-fractionation Homo sapiens
110 RAPGEF5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
111 PRDX1 5052
Co-fractionation Homo sapiens
112 SERBP1 26135
Affinity Capture-MS Homo sapiens
113 PTGES3 10728
Affinity Capture-MS Homo sapiens
114 Sgol1  
Affinity Capture-MS Mus musculus
115 YBEY  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
116 PTPN18 26469
Affinity Capture-MS Homo sapiens
117 RPA3 6119
Proximity Label-MS Homo sapiens
118 PPP2R2D 55844
Co-fractionation Homo sapiens
119 LURAP1  
Affinity Capture-MS Homo sapiens
120 RANGAP1 5905
Co-fractionation Homo sapiens
View the network image/svg+xml
 Pathways in which PPP2R5D is involved
PathwayEvidenceSource
Adaptive Immune System TAS Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal TAS Reactome
Amplification of signal from the kinetochores TAS Reactome
APC truncation mutants have impaired AXIN binding TAS Reactome
AXIN missense mutants destabilize the destruction complex TAS Reactome
Beta-catenin phosphorylation cascade TAS Reactome
Cell Cycle TAS Reactome
Cell Cycle Checkpoints TAS Reactome
Cell Cycle, Mitotic TAS Reactome
Costimulation by the CD28 family TAS Reactome
CTLA4 inhibitory signaling TAS Reactome
CTNNB1 S33 mutants aren't phosphorylated TAS Reactome
CTNNB1 S37 mutants aren't phosphorylated TAS Reactome
CTNNB1 S45 mutants aren't phosphorylated TAS Reactome
CTNNB1 T41 mutants aren't phosphorylated TAS Reactome
Cytokine Signaling in Immune system TAS Reactome
DARPP-32 events TAS Reactome
Degradation of beta-catenin by the destruction complex TAS Reactome
Disassembly of the destruction complex and recruitment of AXIN to the membrane TAS Reactome
Disassembly of the destruction complex and recruitment of AXIN to the membrane IEA Reactome
Disease TAS Reactome
Diseases of signal transduction by growth factor receptors and second messengers TAS Reactome
EML4 and NUDC in mitotic spindle formation TAS Reactome
ERK/MAPK targets TAS Reactome
ERKs are inactivated TAS Reactome
G alpha (i) signalling events TAS Reactome
Glucose metabolism IEA Reactome
Glycolysis IEA Reactome
GPCR downstream signalling TAS Reactome
Hemostasis TAS Reactome
Immune System TAS Reactome
Innate Immune System TAS Reactome
Integration of energy metabolism IEA Reactome
Interleukin-17 signaling TAS Reactome
Intracellular signaling by second messengers TAS Reactome
M Phase TAS Reactome
MAP kinase activation TAS Reactome
MAPK family signaling cascades TAS Reactome
MAPK targets/ Nuclear events mediated by MAP kinases TAS Reactome
MAPK1/MAPK3 signaling TAS Reactome
Metabolism IEA Reactome
Metabolism of carbohydrates IEA Reactome
Mitotic Anaphase TAS Reactome
Mitotic Metaphase and Anaphase TAS Reactome
Mitotic Prometaphase TAS Reactome
Mitotic Spindle Checkpoint TAS Reactome
MyD88 cascade initiated on plasma membrane TAS Reactome
MyD88 dependent cascade initiated on endosome TAS Reactome
MyD88-independent TLR4 cascade TAS Reactome
MyD88:MAL(TIRAP) cascade initiated on plasma membrane TAS Reactome
Negative regulation of MAPK pathway TAS Reactome
Negative regulation of the PI3K/AKT network TAS Reactome
Nuclear Events (kinase and transcription factor activation) TAS Reactome
Opioid Signalling TAS Reactome
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling TAS Reactome
PIP3 activates AKT signaling TAS Reactome
Platelet homeostasis TAS Reactome
Platelet sensitization by LDL TAS Reactome
PP2A-mediated dephosphorylation of key metabolic factors IEA Reactome
RAF activation TAS Reactome
RAF/MAP kinase cascade TAS Reactome
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism IEA Reactome
Resolution of Sister Chromatid Cohesion TAS Reactome
RHO GTPase Effectors TAS Reactome
RHO GTPases Activate Formins TAS Reactome
Separation of Sister Chromatids TAS Reactome
Signal Transduction TAS Reactome
Signal Transduction IEA Reactome
Signaling by AMER1 mutants TAS Reactome
Signaling by APC mutants TAS Reactome
Signaling by AXIN mutants TAS Reactome
Signaling by CTNNB1 phospho-site mutants TAS Reactome
Signaling by GPCR TAS Reactome
Signaling by GSK3beta mutants TAS Reactome
Signaling by Interleukins TAS Reactome
Signaling by NTRK1 (TRKA) TAS Reactome
Signaling by NTRKs TAS Reactome
Signaling by Receptor Tyrosine Kinases TAS Reactome
Signaling by Rho GTPases TAS Reactome
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 TAS Reactome
Signaling by WNT TAS Reactome
Signaling by WNT IEA Reactome
Signaling by WNT in cancer TAS Reactome
TCF dependent signaling in response to WNT TAS Reactome
TCF dependent signaling in response to WNT IEA Reactome
Toll Like Receptor 10 (TLR10) Cascade TAS Reactome
Toll Like Receptor 2 (TLR2) Cascade TAS Reactome
Toll Like Receptor 3 (TLR3) Cascade TAS Reactome
Toll Like Receptor 4 (TLR4) Cascade TAS Reactome
Toll Like Receptor 5 (TLR5) Cascade TAS Reactome
Toll Like Receptor 7/8 (TLR7/8) Cascade TAS Reactome
Toll Like Receptor 9 (TLR9) Cascade TAS Reactome
Toll Like Receptor TLR1:TLR2 Cascade TAS Reactome
Toll Like Receptor TLR6:TLR2 Cascade TAS Reactome
Toll-like Receptor Cascades TAS Reactome
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation TAS Reactome
TRIF (TICAM1)-mediated TLR4 signaling TAS Reactome
Truncations of AMER1 destabilize the destruction complex TAS Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here