Gene description for PTPN18
Gene name protein tyrosine phosphatase, non-receptor type 18 (brain-derived)
Gene symbol PTPN18
Other names/aliases BDP1
Species Homo sapiens
 Database cross references - PTPN18
ExoCarta ExoCarta_26469
Entrez Gene 26469
HGNC 9649
MIM 606587
UniProt Q99952  
 PTPN18 identified in exosomes derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
 Gene ontology annotations for PTPN18
Molecular Function
    protein binding GO:0005515 IPI
    non-membrane spanning protein tyrosine phosphatase activity GO:0004726 IEA
Biological Process
    peptidyl-tyrosine dephosphorylation GO:0035335 TAS
    protein dephosphorylation GO:0006470 TAS
Subcellular Localization
    cytoplasm GO:0005737 IEA
    nucleus GO:0005634 IEA
 Experiment description of studies that identified PTPN18 in exosomes
Experiment ID 191
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PTPN18
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PSTPIP1 9051
Invivo Homo sapiens
Invivo Homo sapiens
Invivo Homo sapiens
View the network image/svg+xml
 Pathways in which PTPN18 is involved
No pathways found

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