Gene description for PTPN18
Gene name protein tyrosine phosphatase, non-receptor type 18 (brain-derived)
Gene symbol PTPN18
Other names/aliases BDP1
PTP-HSCF
Species Homo sapiens
 Database cross references - PTPN18
ExoCarta ExoCarta_26469
Vesiclepedia VP_26469
Entrez Gene 26469
HGNC 9649
MIM 606587
UniProt Q99952  
 PTPN18 identified in exosomes derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
 Gene ontology annotations for PTPN18
Molecular Function
    protein tyrosine phosphatase activity GO:0004725 EXP
    protein tyrosine phosphatase activity GO:0004725 IBA
    non-membrane spanning protein tyrosine phosphatase activity GO:0004726 IEA
    protein binding GO:0005515 IPI
    protein tyrosine phosphatase activity, metal-dependent GO:0030946 IEA
    histone H2AXY142 phosphatase activity GO:0140793 IEA
Biological Process
    blastocyst formation GO:0001825 IEA
    chromatin remodeling GO:0006338 IEA
    protein dephosphorylation GO:0006470 TAS
    negative regulation of ERBB signaling pathway GO:1901185 TAS
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified PTPN18 in exosomes
1
Experiment ID 191
MISEV standards
Biophysical techniques
Alix|CD81|CD9
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors "Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK."
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PTPN18
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DNAJC7 7266
Affinity Capture-MS Homo sapiens
2 CDIPT 10423
Affinity Capture-MS Homo sapiens
3 RHOT1 55288
Affinity Capture-MS Homo sapiens
4 TUBB2A 7280
Affinity Capture-MS Homo sapiens
5 ARL1 400
Affinity Capture-MS Homo sapiens
6 AATK  
Two-hybrid Homo sapiens
7 CNKSR1  
Reconstituted Complex Homo sapiens
8 STUB1 10273
Affinity Capture-MS Homo sapiens
9 WRAP73 49856
Affinity Capture-MS Homo sapiens
10 GRB2 2885
Affinity Capture-MS Homo sapiens
11 AIFM1 9131
Affinity Capture-MS Homo sapiens
12 SSTR4  
Affinity Capture-MS Homo sapiens
13 HSPA8 3312
Affinity Capture-MS Homo sapiens
14 ATXN2 6311
Affinity Capture-MS Homo sapiens
15 NUP155 9631
Affinity Capture-MS Homo sapiens
16 STOML2 30968
Affinity Capture-MS Homo sapiens
17 DNAJA2 10294
Affinity Capture-MS Homo sapiens
18 BAG5 9529
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 C2orf47  
Affinity Capture-MS Homo sapiens
20 IRS4 8471
Affinity Capture-MS Homo sapiens
21 ATP5A1 498
Affinity Capture-MS Homo sapiens
22 SDF4 51150
Affinity Capture-MS Homo sapiens
23 BAG2 9532
Affinity Capture-MS Homo sapiens
24 TRIM7  
Affinity Capture-MS Homo sapiens
25 CBWD2  
Affinity Capture-MS Homo sapiens
26 EGFR 1956
Two-hybrid Homo sapiens
PCA Homo sapiens
27 ARF1 375
Affinity Capture-MS Homo sapiens
28 DDX58 23586
Affinity Capture-RNA Homo sapiens
29 TUBB6 84617
Affinity Capture-MS Homo sapiens
30 NXF1 10482
Affinity Capture-RNA Homo sapiens
31 PSTPIP1 9051
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
32 CPVL 54504
Affinity Capture-MS Homo sapiens
33 MLLT11  
Affinity Capture-MS Homo sapiens
34 TANGO6 79613
Affinity Capture-MS Homo sapiens
35 MOV10 4343
Affinity Capture-RNA Homo sapiens
36 PSTPIP2 9050
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 PPP2R5D 5528
Affinity Capture-MS Homo sapiens
38 TIPRL 261726
Affinity Capture-MS Homo sapiens
39 CBWD3  
Affinity Capture-MS Homo sapiens
40 TARS2 80222
Affinity Capture-MS Homo sapiens
41 NDUFS3 4722
Affinity Capture-MS Homo sapiens
42 AIP 9049
Affinity Capture-MS Homo sapiens
43 CTSB 1508
Affinity Capture-MS Homo sapiens
44 GLA 2717
Affinity Capture-MS Homo sapiens
45 HAX1  
Affinity Capture-MS Homo sapiens
46 PTPN18 26469
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 DNAJB1 3337
Affinity Capture-MS Homo sapiens
48 STIP1 10963
Affinity Capture-MS Homo sapiens
49 PASK  
Affinity Capture-MS Homo sapiens
50 TMX3 54495
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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